Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII by Nishan Mandal, Apurba Das, Rupak Datta

“…Energy depletion triggered apoptosis in neuronal as well as non-neuronal cells of the CG2135−/− fly brain, where apoptotic dopaminergic neurons were also detected. …”
Get full text

Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model by Asbin Mary X, Syed Ali Mohamed Yacoob, Anuradha Venkatraman, Ruban Packiasamy, Meivelu Moovendhan, Murugesan Gnanadesigan, Yogananth Nagarajan

“…Rhizophora mucronata extract (250 mg/kg) was successfully used in in vivo trials to stop the growth of breast cancer cells in groups that had been given DMBA. Based on these findings, it has been concluded that methanolic extract of Rhizophora mucronata leaves (MERML) was safe at both higher and lower dosages and could be assessed for pharmacological study.…”
Get full text

Quercetin Zinc and Iron Metal Complexes Protect against Sodium Arsenite Intoxication in the Hepato-Renal System of Wistar Rats via the Oxidative Stress Pathway by Oluwatoyin O. Ojo, Deborah I. Fatokun, Ikechukwu P. Ejidike, Rachel U. Awolope, Saheed O. Sanni

“…Bioflavonoids are known to influence redox homeostasis in cells; the study therefore investigates the efficacy of quercetin and its zinc and iron metal complexes on sodium arsenite (NaAr)-intoxication in rats. …”
Get full text

Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. by Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne

“…Through small RNA sequencing, we identified programmed overexpression of hypothalamic miR-505-5p that is established in the fetus, lasts to adulthood and is maintained in hypothalamic neural progenitor cells cultured in vitro. Metabolic hormones and long-chain fatty acids associated with obesity increase miR-505-5p expression in hypothalamic neurons in vitro. …”
Get full text

The Role of Silymarin in Mitigating Inflammation and Cognitive Impairment Induced by Ovariectomy in Wistar Rats by Razieh Moalefshahri, Hossein Javid, Fatemeh Gheybi, Somaye Fallahnezhad, Seyed Isaac Hashemy

Get full text

Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile. by Ahmed M Nagy, Heba A Fahmy, Mohamed F Abdel-Hameed, Rehab F Taher, Alaa M Ali, Mohamed M Amin, Sherif M Afifi, Tuba Esatbeyoglu, Mohamed A Farag, Abdelsamed I Elshamy

“…The protective effect of EH-EtOH against testicular degeneration in the rat model of DM was evaluated by measuring improvements in blood glucose levels, body weight, testicular inflammation, oxidative damage, testicular microcirculation impairment, and apoptosis of testicular cells induced by STZ. The chemical profiling of EH-EtOH revealed the presence of 52 compounds, including phenolic acids, flavonoids, coumarins, phloroglucinols, and triterpenes. …”
Get full text

Myelopathy as the first manifestation of AIDS by Yuanyuan Li, Qianru Yang, Hong Lin, Qiong Zhou, Fangfang Ge, Jiankuan Shi

“…Abstract Background Human immunodeficiency virus (HIV) is a retrovirus mainly infecting immune cells. Central nervous system diseases in HIV-infected patients can be caused by HIV or opportunistic infections. …”
Get full text

Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction by Olga I. Rudko, Artemii V. Tretiakov, Elena A. Naumova, Eugene A. Klimov

“…Among three PPAR isoforms, PPARG demonstrates the highest expression in CNS, where it can be found in neurons, astrocytes, and glial cells. Herein, the highest PPARG expression occurs in amygdala. …”
Get full text

The Effect of P-Cymene on Glucose, Insulin, Antioxidant Power, and the Level of AKT Gene mRNA in Streptozotocin-Induced Diabetes Model in Male Wistar Rats by Maryam Arabloei Sani, Zahra Hajebrahimi, Parichehreh Yaghmaei, Nasim Hayati Roodbari

“…The AKT signaling pathways plays a critical role in regulating glucose homeostasis and proliferation of β cells. P-cymene is an aromatic monotropene with antioxidant and anti-inflammatory properties. …”
Get full text

Effect of hydroalcoholic extract of Sambucus nigra on superficial digital flexor tendon repair in rabbit by ultrasonography and histopathology by Niusha Asgari, Elham Moghtadaei‐Khorasgani, Mehrdad Yadegari, Omid Taheri‐Boroujeni

“…Histopathological examination revealed fewer inflammatory cells and increased collagen fibre formation in the treatment groups compared to the other two groups. …”
Get full text

Application of Mesoporous Silica Nanoparticle-Chitosan-Loaded BMP-2 in the Repair of Bone Defect in Chronic Osteomyelitis by Min Yi, Yu Nie, Chengyun Zhang, Bin Shen

“…Bone marrow mesenchymal stem cells (BMSCs) were purchased and cultivated to detect the osteogenesis of chitosan-MSN (Chi-MSN) and polylactic acid glycolic acid (PLGA) delivery system. …”
Get full text

Cytokine and eicosanoid regulation by Schistosoma mansoniduring LSE penetration by A. C. Fusco, B. Salafsky, T. Shibuya

“…It is concluded that cercarial penetration causes a release of IL-1α consistent with skin trauma; however, schistosomulae may regulate the production of chemotactic (neutrophils, macrophages, T-cells, etc.) and activation factors such as IL-8 and LTB4.…”
Get full text

RESULTS OF EXPERIMENTAL INFECTION OF TURKEYS WITH A/DUCK/ALTAI/469/14 H5N1 STRAIN OF AVIAN INFLUENZA VIRUS by V. Yu. Sosipatorova, D. A. Altunin, I. A. Chvala, N. S. Mudrak, D. B. Andreychuk

“…Immunohistochemical analysis showed the greatest distribution of the influenza virus antigen in the cerebral endothelium, cerebellar Purkinje neurons, acinar cells of the pancreas and in myocardiocytes of the heart. …”
Get full text

Species distribution modelling using MaxEnt: overview and prospects by Yuliia Novoseltseva

“…It should be taken into account that when using projections where cells have different areas, MaxEnt may give incorrect results. …”
Get full text

Management of Anal Fistula with Crohn's Disease by Shota Takano, Yasushi Nakamura, Kohei Tamaoka, Takafumi Yoshimoto, Yasue Irei, Yoriyuki Tsuji

“…In addition to biologics, molecular target drugs and even regenerative medicine using mesenchymal stem cells have been introduced to further expand the treatment options for consideration by medical personnel. …”
Get full text

Placenta Creta: A Spectrum of Lesions Associated with Shallow Placental Implantation by Jerzy Stanek

“…Because of the association of PC with gestational hypertensive diseases, acute and chronic placental hypoxic lesions, increased extravillous trophoblasts in the chorionic disc, chorionic microcysts, and maternal floor trophoblastic giant cells, PC should be regarded as a lesion of abnormal placental implantation and abnormal trophoblast invasion rather than decidual deficiency only.…”
Get full text

Powassan Encephalitis: A Case Report from New York, USA by Danielle A. Bazer, Matthew Orwitz, Nicholas Koroneos, Olga Syritsyna, Elizabeth Wirkowski

“…He was empirically treated for possible meningitis, as CSF revealed WBC 370 (80% mononuclear cells); RBC 10, protein 152 mg/dL, and glucose 59 mg/dL. …”
Get full text

Subject matter of crime violation of the procedure for transplantation of human anatomical materials established by law by Yu. O. Tkach

“…It is also advisable to include DNA and DNA fragments in the list of human anatomical material, and to approve a separate list of human cells allowed for extraction, namely DNA and DNA fragments, in the relevant order of the Ministry of Health of Ukraine. …”
Get full text

Effect of high-intensity interval training and moderate-intensity continuous training with quercetin supplementation on the mitochondrial gene expression in the diabetic heart by Mojdeh Khajehlandi, Lotfali Bolboli

“…Background: Mitochondrial function is an integral part of glucose-stimulated insulin secretion in pancreatic β-cells and is a hallmark feature of cardiovascular disease. …”
Get full text

Presence of Serum Antinuclear Antibodies Does Not Impact Outcomes in HBV-Related Acute-on-Chronic Liver Failure by Lin Lin, Bin Lin, Qing Lan, Longgen Liu, Jianchun Lu, Xiujun Zhang, Shuqin Zheng, Yuan Xue

“…Multiple nuclear dots, rim-like, and centromere patterns of ANA were detected using indirect immunofluorescence assay on HEp-2 cells. Results. Among the 116 patients with HBV-related ACLF, 17 (14.66%) were ANA positive. …”
Get full text