Bacterial Toxin Fusion Proteins Elicit Mucosal Immunity against a Foot-and-Mouth Disease Virus Antigen When Administered Intranasally to Guinea Pigs by Sreerupa Challa, Steven M. Szczepanek, Debra Rood, Roger W. Barrette, Lawrence K. Silbart

“…These were also the only groups that exhibited G-H loop-specific antigen-secreting cells in the nasal mucosa. These data demonstrate that fusion of nonreplicating antigens to LTA2B and ntPE-LTA2B has the potential to be used as carriers/adjuvants to induce mucosal immune responses against infectious diseases.…”
Get full text

Improved constructs for bait RNA display in a bacterial three-hybrid assay by Linh D. Nguyen, Hannah LeBlanc, Katherine E. Berry

“…Abstract We have previously developed a transcription-based bacterial three-hybrid (B3H) assay as a genetic approach to probe RNA–protein interactions inside of E. coli cells. This system offers a straightforward path to identify and assess the consequences of mutations in RBPs with molecular phenotypes of interest. …”
Get full text

Oocyte recovery and comparison of maturation rates of different quality oocytes in cattle by Fatma Satılmış, Mehmet Güler

“…The quality of the obtained oocytes was evaluated as A, B, C and D quality according to the cytoplasm density and the distribution of the cumulus cells around the oocyte. 1384 of them, A and B quality, were left to maturation with a commercial maturation medium (BO-IVM,Bioscience, UK)at 38.8 °C with atmospheric O₂ at s5.5% CO₂ for 24 hours. …”
Get full text

MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury by Barbara Pijet, Marzena Stefaniuk, Leszek Kaczmarek

“…The basic units of neuronal connectivity are dendritic spines that are tiny protrusions forming synapses between two cells in a network. Spines are dynamic structures that undergo morphological transformation throughout life. …”
Get full text

ANCA-Negative Vasculitis in Eosinophilic Granulomatosis with Polyangiitis Complicated with Membranous Nephropathy: A Case Report and Brief Literature Review by Eri Kasama, Jun Ino, Fumika Iemura, Saeko Kumon, Mio Kodama, Keitaro Sato, Hitoshi Eizumi, Kosaku Nitta, Junichi Hoshino

“…MPO-and PR3-ANCA were negative, and urinalysis revealed urine protein (0.63 g/day) but without red blood cells in the urine sediment. Thus, she was diagnosed with ANCA-negative EGPA with rapidly progressive renal dysfunction. …”
Get full text

Age-Stratified Analysis of Vaginal Microbiota Dysbiosis and the Relationship with HPV Viral Load in HPV-Positive Women by Mingzhu Li, Chao Zhao, Yun Zhao, Jingran Li, Lihui Wei

“…For this cross-sectional study, 388 HPV-positive women prior to referral to colposcopy in Peking University Peoples’ Hospital were included and classified as younger than 50 years (n=307) and aged 50 years or older (n=81), midvagina bacterial community composition was characterized by FlashDetect™ MAX vaginal microbe detection kit, and BMRT-HPV reported type-specific viral loads/10,000 cells. Results. The community state type (CST) IV was the most common CST occurring in 148 women (38.1%). …”
Get full text

Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis by Ferah Budak, Salih Haldun Bal, Gulcin Tezcan, Halis Akalın, Guher Goral, Haluk Barbaros Oral

“…Here, more than 2000 miRNAs were screened in peripheral blood mononuclear cells (PBMCs) of patients with acute or chronic brucellosis and healthy controls by using miRNA array, and the results of the miRNA array were validated through qRT-PCR. …”
Get full text

The relationship of lamins with epigenetic factors during aging by R. N. Mustafin, E. K. Khusnutdinova

“…The role of lamins in the etiopathogenesis of premature aging syndromes may be associated with interactions with transposons. In various human cells, LINE1 is present in the heterochromatin domains of the genome associated with lamins, while SIRT7 facilitates the interaction of this retroelement with lamins. …”
Get full text

Impaired Mitophagy: A New Potential Mechanism of Human Chronic Atrial Fibrillation by Shuang Zhou, Weiran Dai, Guoqiang Zhong, Zhiyuan Jiang

“…Mitophagy is an autophagic response and plays essential roles in survival, development, and homeostasis of cells. It has been reported that mitophagic dysfunction is involved in several cardiovascular diseases. …”
Get full text

Awareness of prostate cancer and its screening tests in men in the Middle East: A systematic review and meta-analysis by Nawaf S.A. Mohamed, Joud M.O. Asfari, Samar M.A. Sambawa, Rima M.D. Aljurf, Kholoud A.A. Alsaygh, Assad M. Arafah

“…Prostate cancer (PCa) is a significant health issue characterized by the uncontrolled growth of cells in the prostate gland primarily affecting men 50 years old or older. …”
Get full text

CORRELATION BETWEEN APOPROTEIN B/APOPROTEIN A-I RATIO WITH HOMA IR VALUE (HOMEOSTATIC MODEL ASSESMENT INSULIN RESISTANCE) IN TYPE 2 DIABETES MELLITUS by Muhammad Rafli Afandi, Ferdy Royland Marpaung

“…Type2 DM is caused by the body cells’ inability to respond normally to insulin (insulin resistance). …”
Get full text

Functional morphology of digestive organs of newborn calves and pathogenesis of escherichiosis by S. M. Suleymanov

“…Samples from 6 clinically healthy calves of a similar age were used as control.It was found that newborn calves at the initial stage of escherichiosis demonstrated early structural changes in the ultrastructure of mucosa cells of the rennet and small intestine, as well as in the liver parenchyma, and mild changes – in the exocrine part of the pancreas. …”
Get full text

RESPONSE OF LOCAL ORANGE TRANSPLANTS TO BIO AND ORGANIC FERTILIZERS AND SPRAYING WITH MORINGA LEAVES EXTRACT by Fatima Saad Hameed AL-Marsoumi, Mustafa, E. A. AL-Hadethi

“…Experimental results showed that adding two types of bacteria (A4) and buffalo manure at a level of 500 g.soil-1 (B2) and spraying moringa extract at a concentration of 40 g.L-1 (M2) as interaction treatment A4B2M2 produced best results in shoot  number, stem diameter,  leaf potassium and iron percent %, and epidermal and spongy cells layers thickness, (25.00, 41.00) shoot.plant-1, (14.247, 5.283) mm, (2.980, 2.885) %, (215.8, 220.7) mg.kg-1 for two growing seasons, respectively, and (48.60, 108.4) micrometer, respectively compared to control treatment. …”
Get full text

PyBootNet: a python package for bootstrapping and network construction by Shayan R. Akhavan, Scott T. Kelley

“…Background Network analysis has emerged as a tool for investigating interactions among species in a community, interactions among genes or proteins within cells, or interactions across different types of data (e.g., genes and metabolites). …”
Get full text

The Irony of American History. Reinhold Niebuhr and the American Experience by Avihu Zakai

“…Sur la page de couverture de l’édition publiée à l’occasion de cet anniversaire se trouvait une photographie de Reinhold Niebuhr (1892-1971) avec pour légende « L’histoire de l’homme n’est pas celle d’une réussite ». Cette expression faisait allusion aux principes théologiques de Niebuhr, à sa critique de la société en général et plus particulièrement de l’expérience américaine. …”
Get full text

Induction of Resistance to Larvae Crocidolomia pavonana F. (Lepidoptera: Crambidae) using Rhizobacteria to the Cabbage by Indri Yanil Vajri, Trizelia, Haliatur Rahma

“…The test was carried out by soaking the seeds in a suspension containing rhizobacteria with a population density of 10⁸ cells/ml. The variables observed were larval mortality, pupa and imago formation percentage, and increased salicylic acid production. …”
Get full text

Pattern of F-18 FDG Uptake in Colon Cancer after Bacterial Cancer Therapy Using Engineered Salmonella Typhimurium: A Preliminary In Vivo Study by Ari Chong, Dinh-Huy Nguyen, Hyeon Sik Kim, June-Key Chung, Jung-Joon Min

“…BCT was performed via the intravenous injection of attenuated S. typhimurium (SLΔppGpp/lux) into female mice bearing a tumor (derived from CT26 murine colon cancer cells) in the right thigh. 18F-FDG PET images acquired before BCT and at different time points after BCT. …”
Get full text

Aweak phenotype associated with novel ABO*A allele variant c.106delinsGG by Sanmukh Ratilal Joshi, Glenda Millard, Mayuri Vekariya, Priya Radadiya, Manisha Rajapara, Hiren Dhanani, Gaurav Shastri, Prabhat Sharma, Brett Wilson, Yew-Wah Liew

“…Binary alignment mapping files, generated on board the Illumina MiSeq instrument and aligned to the GRCh37/Hg19 reference genome, were uploaded to the QIAGEN CLC genomics workbench software (version. 20) where variant call files were generated and analyzed. RESULTS: Red blood cells (RBCs) of six healthy donors, showing weak mix-field agglutination by anti-A and anti-A, B and plasma with absence or weakly reacting anti-A, were investigated serologically. …”
Get full text

Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases by Zhenbo Shu, Chunsheng Li, Mingze Sun, Zhongmin Li

“…Immunohistochemical analysis showed that the tumor cells were positive for S-100 and negative for CD117, DOG-1, desmin, and smooth muscle actin. …”
Get full text

Metastatic urothelial carcinoma in multiple appendicular muscles of a cat by Eduardo M Hernández, Pedro J Ginel, Beatriz Blanco, Yolanda Millán, Maria T Jiménez, Elena Mozos

“…Fine-needle aspiration of the muscle lesions revealed nests and isolated pleomorphic large neoplastic cells consistent with a carcinoma (vs sarcoma) and one mass was surgically removed. …”
Get full text