MiR-223 within neutrophil axis promotes Th17 expansion by PI3K-AKT pathway in systemic lupus erythematosus by Chengzhong Zhang, Yan Lu

“…The aim of this study is to assess the presence of miR-223 within neutrophils in SLE and investigate its impact on the expansion of Th17 cells. Methods Experiments were performed in MRL/lpr mice, which were divided into control and miR-223 knockdown (miR-223-) group. …”
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Une image vaut mille mots : la crise d’Oka de 1990 et sa représentation par une photographie by Émilie Guilbeault-Cayer

“…La presse canadienne fait état d’un événement qui choque la population, particulièrement celle du Québec. Le 11 juillet, un affrontement entre la Sûreté du Québec et les Mohawks de Kanesatake fait un mort, le caporal Marcel Lemay. …”
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Development of a lean maturity assessment model using interval-valued spherical fuzzy AHP method by Alper Kiraz, Asiye Yücedag Gürel

“…To determine the LMLs, the leveling scale (understanding, implementation, improvement, and sustainability) was used from the model for LMLs in manufacturing cells. As a result of the analysis of the survey results obtained from the participating companies, the overall LML was calculated as 2.55 out of 4. …”
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Mechanisms of Cancer-Induced Bone Pain by Wang X, Li L, Wang Y

“…The spinal cord is the main processing center for nociceptive signals. When tumor cells produce inflammatory mediators that acidify the microenvironment or damage nerve endings, the spinal cord becomes excessively stimulated, resulting in increased or prolonged pain signals that propagate to the higher central nervous system through the ascending pathway. …”
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Marked point process variational autoencoder with applications to unsorted spiking activities. by Ryohei Shibue, Tomoharu Iwata

“…Our model achieves superior performance in prediction and decoding tasks for synthetic data and the spiking activities of place cells.…”
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A study of acute transfusion reactions at a tertiary care center: a retrospective analysis by Damayanti R. Dey, Shweta W. Dhote, Subhangi Y. Lad, Sonal S. Gupta

“…Among the reported ATRs, 37 (97.36%) were associated with packed red cells (PRC), while 1 (2.64%) occurred with fresh frozen plasma (FFP). …”
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Scale-Up of Tailor-Made Onsite Enzyme Blend From Cassava Peels for Industrial Bioethanol Production by Martison Budu, Patrick Boakye, Joseph A. Bentil

“…Tailor-made enzyme blends were produced with the A. niger using various substrate concentrations (1%, 3%, 5%, 8%, and 10%) of milled cassava peels at periods of 2, 4, 6, 8, and 10 days with a spore concentration of 2.1 × 105 cells/mL. The amylolytic and cellulolytic activities were determined as 4.759 U/mL and 4.265 U/mL, respectively, at 5% and 6-day optimal conditions. …”
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Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions by Stefania Kalampokini, Anouck Becker, Klaus Fassbender, Epameinondas Lyros, Marcus M. Unger

“…Food-based therapies may favorably modulate gut microbiota composition and enhance the intestinal epithelial integrity or decrease the proinflammatory response by direct effects on immune cells. Diets rich in pre- and probiotics, polyunsaturated fatty acids, phenols including flavonoids, and vitamins, such as the Mediterranean diet or a plant-based diet, may attenuate chronic inflammation and positively influence PD symptoms and even progression of the disease. …”
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Comparison of Blood and Tissue Eosinophil Count and Blood IgE in Patients with Chronic Sinusitis and Nasal Polyps by Masoud Asghari, Shadi Izadpanahi, Mina Heidari Esfahani

“…Also, samples taken from patients during surgery were counted, and then, 100 cells were counted, and eosinophil counts and percentages were calculated. …”
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Receptor Status Differences in Prognosis for Breast Cancer by Yelda Deligöz Bildacı, Deniz Yamaç, Uğur Coşkun

“…Objective: Breast cancer is a type of cancer that originates in breast tissue cells. It is the most common cancer type in the world after lung cancer. …”
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Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization by Feng Zhao, Wenlei Fei, Zhouyue Li, Hanyang Yu, Lei Xi

“…The present study is aimed at investigating the cytotoxicity and antiangiogenic effects of PEDF-loaded PEGylated nanoparticles (NP-PEG-PEDF) on high glucose-stimulated human umbilical vein endothelial cells (HUVECs). Methods. In this study, NP-PEG-PEDF were fabricated using the multiple emulsion method for the first time. …”
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Landscape of Alternative Splicing Events Related to Prognosis and Immune Infiltration in Glioma: A Data Analysis and Basic Verification by Hong-xin Su, Gang Yang, Fei Su, Chen-xiao Hu, Tao Zhang, Jun-tao Ran, Quan-lin Guan

“…The immune infiltration analysis demonstrated that AS events were related to the proportion of immune cells infiltrating in glioma. Conclusions. It is of great value for comprehensive consideration of AS events, splicing networks, and related molecular subtype clusters in revealing the underlying mechanism and immune microenvironment remodeling for glioma, which provides clues for the further verification of related therapeutic targets.…”
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Evolution of the Macrophage CD163 Phenotype and Cytokine Profiles in a Human Model of Resolving Inflammation by Betsy J. Evans, Dorian O. Haskard, Gregory Sempowksi, R. Clive Landis

“…Neutrophils acquired apoptotic markers at 40 h and were observed to be phagocytosed by macrophagic “Reiter’s” cells. Multiplex cytokine analysis demonstrated that monocyte chemoattractant protein (MCP-1/CCL2), interleukin- (IL-) 6, IL-8/CXCL8, macrophage inflammatory protein (MIP1α/CCL3), MIP-1β/CCL4, tumor necrosis factor- (TNF-) α, and eotaxin (CCL11) were all significantly upregulated at 16 h compared with 40 h. …”
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Loss of Mfn1 but not Mfn2 enhances adipogenesis. by Jake P Mann, Luis Carlos Tábara, Satish Patel, Pushpa Pushpa, Anna Alvarez-Guaita, Liang Dong, Afreen Haider, Koini Lim, Panna Tandon, Fabio Scurria, James E N Minchin, Stephen O'Rahilly S, Daniel J Fazakerley, Julien Prudent, Robert K Semple, David B Savage

“…In this study, we aimed to document the impact of loss of mitofusin 1 (Mfn1) or 2 (Mfn2) on adipogenesis in cultured cells.<h4>Methods</h4>We characterised adipocyte differentiation of wildtype (WT), Mfn1-/- and Mfn2-/- mouse embryonic fibroblasts (MEFs) and 3T3-L1 preadipocytes in which Mfn1 or 2 levels were reduced using siRNA.…”
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High Lyso-Gb3 Plasma Levels Associated with Decreased miR-29 and miR-200 Urinary Excretion in Young Non-Albuminuric Male Patient with Classic Fabry Disease by Sebastián Jaurretche, Germán R. Perez, Graciela Venera

“…Pathological albuminuria, the first Fabry nephropathy clinical manifestation, can occur from early childhood, although histological lesions such as tubulo-interstitial fibrosis and glomerulosclerosis are present or may precede the onset of pathological albuminuria. In renal cells, exposure to Lyso-Gb3 is correlated with increased expression of Transforming Growth Factor-βeta (TGF-β). miR-21, miR-192, and miR-433 that promote fibrosis are activated by TGF-β, and miR-29 and miR-200 that suppress fibrosis are inhibited by TGF-β. …”
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Dealing with post-excavation data: the Omeka S TiMMA web-database by Rueff, Bastien

“…The TiMMA project also faces the limitations of Omeka S, such as the lack of efficiency of the search engine, which makes the use of web-semantic vocabularies difficult, a few bugs, and the absence of convenient functionalities in archaeological projects (e.g. the automatic creation of primary keys, a statistic dashboard, cells’ automatic filling). Despite these limitations, the TiMMA project contributes to showing that, without being a complete archaeological system recording, Omeka S is adapted to post-excavation projects. …”
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Bullous Scabies in an Immunocompromised Host by James R. Wester, Lesley E Jackson, Kathryn Mokgosi, Tomer Barak, Mahmoud Abu Hazeem

“…On admission, CD4 count was 46 cells/mm3 and viral load was >750000 copies/mL. Pulmonary tuberculosis testing via sputum was negative twice. …”
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Involvement of a 1-Cys peroxiredoxin in bacterial virulence. by Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Suelen Silvana dos Santos, Luis Eduardo Soares Netto, Sandro Rogério de Almeida, Regina Lúcia Baldini

“…Although no differences in the phagocytosis rates were observed when macrophages were infected with wild-type and mutant bacteria in a gentamicin exclusion assay, a higher number of wild-type bacterial cells was found in the supernatant. This difference was not observed when macrophages were pre-treated with a NADPH oxidase inhibitor, confirming the role of LsfA in the bacterial resistance to ROS generated via NADPH oxidase. …”
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Chromosomes and speciation in tuco-tuco (Ctenomys, Hystricognathi, Rodentia) by A. A. Torgasheva, E. A. Basheva, M. J. Gomez Fernandez, P. Mirol, P. M. Borodin

“…The classic version of this hypothesis emphasizes the sterility of the hybrids, due to incorrect or incomplete chromosome synapsis in heterozygotes for rearrangements, germ cells death, chromosome nondisjunction and the generation of unbalanced gametes. …”
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Erwinia phage Asesino is a nucleus-forming phage that lacks PhuZ by Amy Prichard, Annika Sy, Justin Meyer, Elizabeth Villa, Joe Pogliano

“…Consistent with a lack of PhuZ, however, we did not observe active positioning or rotation of the phage nucleus within infected cells. These data show that some nucleus-forming phages have evolved to replicate efficiently without PhuZ, providing an example of a unique variation in the nucleus-based replication pathway.…”
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