Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

“…An increased level of circulating DHA inhibits PD-L1 expression in tumor cells by binding the PD-L1 promoter and subsequently prevents c-myc-initiated transcription of PD-L1. …”
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Non-Linear Signal Analysis Applied to Surface Wear Condition Monitoring in Reciprocating Sliding Testing Machines by Francisco Paulo Lépore Neto, José Daniel Biasoli de Mello, Marcelo Braga dos Santos

“…The global output force is simultaneously measured by a piezoelectric and by a piezoresistive load cells. The sphere and prismatic body vibrations are measured by a laser Doppler vibrometer and by an accelerometer respectively. …”
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Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration by Yen-Hong Lin, Cheng-Yu Chen, Kun-Hao Chen, Ting-You Kuo, Tsung-Li Lin, Ming-You Shie

“…In vitro assays revealed that the LiCS cement enhanced the proliferation, adhesion, and spread of Wharton’s jelly mesenchymal stem cells (WJMSCs). Additionally, Li-CS cement exhibited remarkable immunomodulatory properties by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines, promoting the polarization of macrophages towards the M2 phenotype. …”
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A Modular and Scalable Approach to Hybrid Battery and Converter Integration for Full-Electric Waterborne Transport by Ramon Lopez-Erauskin, Argiñe Alacano, Aitor Lizeaga, Giuseppe Guidi, Olve Mo, Amaia Lopez-de-Heredia, Mikel Alzuri

“…The proposed system is realized with modular DC-DC converters, which do not require complex design and control or a high number of components and combine high-power (HP) and high-energy (HE) battery cells to optimize the energy and power requirements of vessel operations without oversizing the energy storage system. …”
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A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease by Vladimira Durmanova, Zuzana Parnicka, Juraj Javor, Gabriel Minarik, Lubomir Vrazda, Barbora Vaseckova, Karin Gmitterova, Maria Kralova, Jan Pecenak, Peter Filipcik, Ivana Shawkatova

“…The integrin molecule α4β1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS. Therefore, the objective of our study was to analyze the association between two polymorphisms located in the ITGA4 gene encoding the α4 subunit of VLA-4 and the risk of AD. 104 late-onset AD patients and 206 control subjects from Slovakia were genotyped for ITGA4 gene SNP polymorphism rs113276800 (−269C/A) and rs1143676 (+3061A/G). …”
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Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice by Mina Zhang, Bo Lian, Rui Zhang, Yuhong Guo, Jingxia Zhao, Shasha He, Yunjing Bai, Ning Wang, Yan Lin, Xuerui Wang, Qingquan Liu, Xiaolong Xu

“…In vitro study also showed that emodin inhibited LPS-induced inflammatory response in intestinal epithelial cells. Nuclear factors including NF-κB and AP-1 were further identified as downstream effectors of JNK2. …”
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Prenatal Diagnosis of 4p and 4q Subtelomeric Microdeletion in De Novo Ring Chromosome 4 by Halit Akbas, Naci Cine, Mahmut Erdemoglu, Ahmet Engin Atay, Selda Simsek, Aysegul Turkyilmaz, Mehmet Fidanboy

“…Cytogenetic analysis of cultured amniyotic fluid cells revealed out ring chromosome 4. Both maternal and paternal karyotypes were normal. …”
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Enhanced Urea Oxidation Reaction Through Layered Double Hydroxides: Insights From ZIF‐67‐Derived Nanostructures by Yuri Jeon, Jury Medvedev, Yeeun Seong, Xenia Medvedeva, Cheongwon Bae, Jeongeon Kim, Anna Klinkova, Juyeong Kim

“…LDHs have shown high electrochemical activity in energy conversion systems such as batteries and fuel cells. In this study, we developed a hierarchically porous nanostructure derived from zeolitic imidazolate framework‐67, which was subsequently transformed into an LDH structure with varying Ni concentrations. …”
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Preparation and Study Annealing Effect on Structure and Optical Properties of ZnIn2(Se0.8Te0.2)4 Thin Film by Bushra H. Hussein, Husham Kamil Mahmood

“…(ZIST) Thin film is widely regarded as a remarkable semiconductor material for the development of second-generation solar cells. ZnIn2(Se0.8Te0.2)4 films are polycrystalline with excellent stoichiometric composition, as shown by XRD and AFM investigations. …”
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Application of Principal Component Analysis as a Prediction Model for Feline Sporotrichosis by Franco Bresolin Pegoraro, Rita Maria Venâncio Mangrich-Rocha, Saulo Henrique Weber, Marconi Rodrigues de Farias, Elizabeth Moreira dos Santos Schmidt

“…Principal component analysis (PCA) with two principal components, followed by binary logistic regression, and binary logistic regression analysis, with independent variables and backward elimination modeling, were performed to evaluate hematological (n = 56) and biochemical (n = 34) analytes, including red blood cells, hemoglobin, hematocrit, leukocytes, segmented neutrophils, band neutrophils, eosinophils, lymphocytes, monocytes, total plasma protein, albumin, urea, creatinine, and alanine aminotransferase. …”
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Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility by Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby

“…In its absence, human cells exhibit greater sensitivity towards anti-cancer drugs such as mitomycin C and camptothecin. …”
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Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization by Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M. Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie

“…Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. …”
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Optimization of Solar Hybrid Power Generation Using Conductance-Fuzzy Dual-Mode Control Method by S. Ramesh, J. Seetha, G. Ramkumar, Satyajeet Sahoo, T. M. Amirthalakshmi, A. Ranjith, Asiful H. Seikh, Sohail M. A. Khan Mohammed, Ram Subbiah

“…Turbines, solar photovoltaics, diesel engines, fuel cells, aqua-electrolyzes, and other autonomous generation products are used in the hybrid renewable energy system. …”
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Severe Postpartum Hemorrhage from Uterine Atony: A Multicentric Study by Carlos Montufar-Rueda, Laritza Rodriguez, José Douglas Jarquin, Alejandra Barboza, Maura Carolina Bustillo, Flor Marin, Guillermo Ortiz, Francisco Estrada

“…Similarly, the current proposals of transfusion therapy in severe or massive hemorrhage point to early transfusion of blood products and use of fresh frozen plasma, in addition to packed red blood cells, to prevent maternal deaths.…”
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Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies by Boris Bogdanow, Max Ruwolt, Julia Ruta, Lars Mühlberg, Cong Wang, Wen-feng Zeng, Arne Elofsson, Fan Liu

“…Combining both approaches maintains low error rates and minimizes false negatives, as we show by mathematical simulations, analysis of experimental ground-truth data, and application to various biological datasets. In human cells, inter-link identifications increase by 75% and we confirm their structural accuracy through proteome-wide comparisons to AlphaFold2-derived models. …”
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Identification of a novel SPTB gene splicing mutation in hereditary spherocytosis: a case report and diagnostic insights by Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Xuemei Li, Li Wang, Li Wang, Li Wang, Li Wang, Qian Li, Qian Li, Qian Li, Qian Li, Qianqian Liu, Qianqian Liu, Qianqian Liu, Qianqian Liu, Chengyin He, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Junling Tang, Junling Tang, Junling Tang, Junling Tang

“…BackgroundHereditary spherocytosis (HS) is a group of genetically heterogeneous hereditary hemolytic disorders characterized by anemia, splenomegaly, jaundice, reticulocytosis, and spherical red blood cells on peripheral blood smears. Mutations in key genes, including SPTB, ANK1, SLC4A1, SPTA1, and EPB42, are commonly implicated in HS.Case PresentationWe report the case of a 22-year-old female presenting with anemia, jaundice, and a family history of splenectomy. …”
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Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats by Wenjuan Liu, Wei Gong, Min He, Yemei Liu, Yeping Yang, Meng Wang, Meng Wu, Shizhe Guo, Yifei Yu, Xuanchun Wang, Fei Sun, Yiming Li, Linuo Zhou, Shengmei Qin, Zhaoyun Zhang

“…After the onset of diabetes, rats were treated with either SPR (STZ + SPR) or saline (STZ + NS) for 12 weeks; nondiabetic rats were used as controls (NDCs). In vitro, H9C2 cells were exposed to aldosterone, with or without SPR. …”
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Oxidative toxicity mediated oophoritis alters ovarian growth in Channa punctatus under prolonged exposure to herbicide, paraquat dichloride by Anamika Jain, Shefalee Singh, Seema Yadav, Aastha Dubey, Yashika Awasthi, Vidyanand Tiwari, Vivek Kumar, Indrani Dubey, Sunil P. Trivedi, Manoj Kumar

“…At each exposure period, a significant (p < 0.05) rise in endogenous reactive oxygen species in blood cells and activities of oxidative markers in the ovary tissue were observed in treated groups. …”
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Establishment of a Breeding Approach Combined with Gamma Ray Irradiation and Tissue Regeneration for Highbush Blueberry by Xuan Yu, Haidi Yuan, Yihong Jin, Chuizheng Xia, Jiani Zhu, Jiali Che, Jiao Yang, Xiaofei Wang, Bingsong Zheng, Shufang Yang, Cristian Silvestri, Fuqiang Cui, Jianfang Zuo

“…We established a high-efficiency regeneration protocol, which was applied to leaves and stems exposed to gamma irradiation using ⁶⁰Co-γ rays at doses of 10, 20, 40, 80, and 120 gray (Gy), to increase the efficiency of mutated cells to develop into adventitious shoots. We determined that the median lethal dose (LD₅₀) was approximately 56 Gy for leaf explants and 80 Gy for stem explants. …”
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Comparison of the Effect of Two Purification Methods on the Immunogenicity of Recombinant Outer Membrane Protein H of Pasteurella multocida Serovar A:1 by Arunee Thanasarasakulpong, Pichayanut Poolperm, Weerapongse Tangjitjaroen, Thanya Varinrak, Takuo Sawada, Dirk Pfeiffer, Nattawooti Sthitmatee

“…The average number of adhesions to CEF cells was statistically significantly lower in sera from chickens immunized with rOmpH or native OmpH purified using electroelution than in those of the three other treatment groups. …”
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