Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats by Yonglin Zhao, Junjie Zhao, Ming Zhang, Yahui Zhao, Jiaxi Li, Xudong Ma, Tingqin Huang, Honggang Pang, Bo Wang, Jinning Song

“…In this study, we demonstrated the expression of TLR2 levels in cortex, corpus callosum, and internal capsule and the localization of TLR2 in neurons and glial cells in rat DAI models. Intracerebral knockdown of TLR2 significantly downregulated TLR2 expression, attenuated cortical apoptosis, lessened glial response, and reduced the secondary axonal and neuronal injury in the cortex by inhibiting phosphorylation of mitogen-activated protein kinases (MAPK) including Erk, JNK, and p38, translocation of NF-κB p65 from the cytoplasm to the nucleus, and decreasing levels of proinflammatory cytokines including interleukin-6, interleukin-1β, and tumor necrosis factor-α. …”
Get full text

Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH by Tobias Obermann, Teri Sakshaug, Vishnu Vignesh Kanagaraj, Andreas Abentung, Mirta Mittelstedt Leal de Sousa, Lars Hagen, Antonio Sarno, Magnar Bjørås, Katja Scheffler

“…Here, we applied an improved OG-sequencing approach reducing artificial background oxidation and RNA-sequencing to correlate genome-wide distribution of OG with gene transcription in OGG1 and/or MUTYH-deficient cells. Our data identified moderate enrichment of OG in the genome that is mainly dependent on the genomic context and not affected by DNA glycosylase-initiated repair. …”
Get full text

The formation and the study of a collection of the Miscanthus resource species gene pool in the conditions of the West Siberian forest steppe by O. V. Dorogina, O. Yu. Vasilyeva, N. S. Nuzhdina, I. V. Buglova, E. V. Zhmud, G. A. Zueva, O. V. Kominа, I. S. Kuban, A. S. Gusar, R. V. Dudkin

“…Based on histochemical analysis, sclerenchyma cells were characterized by the most lignin-rich thickened membranes, so the most appropriate direction in Miscanthus selection should be based on identification and using less lignin-containing samples.…”
Get full text

Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles by Seyyed Sam Mehdi Hosseininasab, Rasoul Ebrahimi, Shirin Yaghoobpoor, Kiarash Kazemi, Yaser Khakpour, Ramtin Hajibeygi, Ashraf Mohamadkhani, Mobina Fathi, Kimia Vakili, Arian Tavasol, Zohreh Tutunchian, Tara Fazel, Mohammad Fathi, Mohammadreza Hajiesmaeili

“…Also, they can regulate gene expression in human cells. This article provides an overview of the association between AD and various infectious agents, with a focus on the mechanisms by which these pathogens may be related to the pathogenesis of AD. …”
Get full text

Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice by Shirong Zheng, Susan Coventry, Lu Cai, David W. Powell, Venkatakrishna R. Jala, Bodduluri Haribabu, Paul N. Epstein

“…Human biopsies stained with ACKR2 antibody revealed increased staining in diabetic kidney, especially in some tubule and interstitial cells. The results demonstrate a significant interaction between diabetes and ACKR2 protein in the kidney. …”
Get full text

Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers by Zhenyu Qian, Yan Jia, Guanghong Wei

“…Increasing evidence suggests that the interaction of human islet amyloid polypeptide (hIAPP) with lipids may facilitate hIAPP aggregation and cause the death of pancreatic islet β-cells. However, the detailed hIAPP-membrane interactions and the influences of lipid compositions are unclear. …”
Get full text

YTHDF1-mediated m6A modification of GBP4 promotes M1 macrophage polarization in acute lung injury by Fengan Cao, Shilei Wang, Qiuyue Tan, Junna Hou, Yunlu Li, Wentao Ma, Shilong Zhao, Jing Gao

“…YTHDF1 was found to enhance GBP4 expression by recognizing m6A sites on its mRNA, which was linked to reduced inflammation in MLE-12 cells upon YTHDF1 knockdown. Conclusion The study emphasizes the crucial roles of GBP4 and YTHDF1 in ALI development and immune response regulation. …”
Get full text

A Low-Overhead and High-Security Scan Design Based on Scan Obfuscation by Weizheng Wang, Xingxing Gong, Shuo Cai, Jiamin Liu, Xiangqi Wang

“…In this method, to increase the security of the design, we insert a set of fuse-antifuse cells (CF) controlled by the obfuscation key between the scan flip flops (SFF) and add a controller at the scan-out port. …”
Get full text

Punica granatum L. (Pomegranate) Extract: In Vivo Study of Antimicrobial Activity against Porphyromonas gingivalis in Galleria mellonella Model by Livia Aparecida Procópio Gomes, Lívia Mara Alves Figueiredo, Ana Luiza do Rosário Palma, Barbara Maria Corrêa Geraldo, Kelly Cristine Isler Castro, Luciana Ruano de Oliveira Fugisaki, Antônio Olavo Cardoso Jorge, Luciane Dias de Oliveira, Juliana Campos Junqueira

“…A suspension of P. gingivalis (106 cells/mL) was inoculated in the left last proleg and PGE (12.5, 6.25, 3.1, and 2.5 mg/mL) were injected into the right proleg. …”
Get full text

Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care by Alessia Silla, Angela Punzo, Francesca Bonvicini, Matteo Perillo, Marco Malaguti, Antonello Lorenzini, Ismaela Foltran, Dario Mercatante, Mara Mandrioli, Maria Teresa Rodriguez-Estrada, Silvana Hrelia, Cristiana Caliceti

“…The biological activities of the extracts and the mouthwash (MW) containing them were evaluated in Human Primary Gingival Epithelial cells (HGECs). The antioxidant and anti-inflammatory activities were analyzed in HGECs injured with lipopolysaccharides. …”
Get full text

IncF Plasmids Are Commonly Carried by Antibiotic Resistant Escherichia coli Isolated from Drinking Water Sources in Northern Tanzania by Beatus Lyimo, Joram Buza, Murugan Subbiah, Sylivester Temba, Honest Kipasika, Woutrina Smith, Douglas R. Call

“…Over 80% of the donor cells successfully passed their resistance traits and eleven different replicon types were detected (IncI1, FIC, P, FIIA, A/C, FIB, FIA, H12, K/B B/O, and N). …”
Get full text

A Case of Mucosal Cancer of the Stomach Treated by Endoscopic Submucosal Dissection after Which Nodal Metastasis Became Evident by Takashi Obana, Naotaka Fujita, Yutaka Noda, Dai Hirasawa, Kei Ito, Toshiki Sugawara, Yoshihiro Harada, Tetsuya Oohira, Hiroshi Honda, Takashi Sawai

“…Histological reexamination of the ESD specimen using immunohistochemistry showed lymphatic invasion of cancer cells in the lamina propria of the 0-I lesion 13 mm in size.…”
Get full text

Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice by Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy

“…AaEE also significantly decreased TNF-α, IFN-γ, and IL-1β cytokine levels compared to DSS-treated mice and reduced both infiltration of inflammatory cells and the mucosal damage in colon. The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. …”
Get full text

Two-Step Facile Preparation of 2D MoS2/ZnO Nanocomposite p-n Junctions with Enhanced Photoelectric Performance by Ali Aldalbahi, Zhen-Bo Wang, Tansir Ahamad, Saad M. Alshehri, Peter X. Feng

“…Both p-n and n-p heterojunctions of ZnO-MoS2 have been fabricated in order to understand the performance of electron and hole transport properties in solar cells and a self-powered photodetector system. Atomically thin 2-dimensional (2D) MoS2 was prepared by using a spin coating method with controlled process times, whereas ZnO nanowires were prepared by using a plasma sputtering deposition technique. …”
Get full text

Pulsed Low-Intensity Focused Ultrasound (LIFU) Activation of Ovarian Follicles by Yan Xiao, Lixia Yang, Yicong Wang, Yu Wang, Yuning Chen, Wenhan Lu, Zhenle Pei, Ruonan Zhang, Yao Ye, Xiaowei Ji, Suying Liu, Xi Dong, Yonghua Xu, Yi Feng

“…<italic>Conclusion:</italic> LIFU treatment could trigger actin changes in ovarian cells, which might disrupt the Hippo signal pathway to promote follicle formation, and the mechanical impact on the ovaries of PCOS-like rats improved antral follicle development.…”
Get full text

Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy by Florencia B. González, Florencia B. González, Antonella Pacini, Araceli Castro, Susana Lioi, Silvina R. Villar, Silvina R. Villar, Luciano D’Attilio, Luciano D’Attilio, Rodolfo D. Leiva, Rodolfo D. Leiva, Liliana Favaloro, Oscar A. Bottasso, Oscar A. Bottasso, Carlos A. Vigliano, Carlos A. Vigliano, Ana Rosa Pérez, Ana Rosa Pérez

“…However, the involvement of glucocorticoid receptors (GR) and their isoforms have been unexplored.Materials and methodsThe expression of GR-α/β isoforms, 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1), inflammatory cytokines, and the GC-regulated gene tristetraprolin (TTP) in peripheral blood mononuclear cells (PBMCs) as well as GR immunoreactivity in the myocardium from CCC individuals were evaluated by qPCR and immunohistochemistry respectively. …”
Get full text

Molecular Characterization and Expression of <i>unc-13d</i> in the Sex Reversal of <i>Monopterus albus</i> by Zitong Lian, Fang Meng, Xueping Xia, Junchao Fang, Haifeng Tian, Qiaomu Hu

“…A strong signal of <i>unc-13d</i> was detected in oocytes and granulosa cells in the ovary and spermatogonia and primary spermatocytes in the testes. …”
Get full text

Role of autophagy defects and significance of adherent-invasive <i>Escherichia coli</i> in Crohn's disease development by I. V. Mayev, D. N. Andreev, D. V. Rakitina, Yu. P. Baykova

“…This phenotype of microorganisms has capacity of adhesion to mucosal epithelial cells, invasion, and active replication inside macrophages. …”
Get full text

Diet-Induced Adipocyte Browning by Oskar Wojciech Wiśniewski, Aleksander Rajczewski, Agnieszka Szumigała, Magdalena Gibas-Dorna

“…The adipocyte browning process is a phenomenon that consists in the molecular and morphological remodeling of preadipocytes or mature white adipocytes into multilocular beige fat cells expressing thermogenesis-associated genes. …”
Get full text

Regular exercise in adolescents with ACE gene polymorphism helps preventing cardiovascular risk factors by Nivaldo de Jesus Silva Soares Junior, Carlan Senna, Carlos Alberto Alves Dias-Filho, Bruno Rodrigues, Maria Claudia Irigoyen, Danielle da Silva Dias, Vinícius Santos Mendes, Carlos José Moraes Dias, Sally Cristina Moutinho Monteiro, Cristiano Teixeira Mostarda

“…Afterward, an electrocardiogram was performed to analyze heart rate variability and oral mucosal cells were collected for the genotypic of angiotensin-converting enzyme. …”
Get full text