Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes by Yang Liu, Ke Zheng, Yecheng Liu, Huadong Zhu

“…The cut-off value of 71 cells/μl for the CD4+ T lymphocyte count was determined to identify patients with poor prognosis. …”
Get full text

Alkylresorcinols as a New Type of Gut Microbiota Regulators Influencing Immune Therapy Efficiency in Lung Cancer Treatment by Aleksandr V. Shestopalov, Oleg I. Kit, Anastasia A. Zabolotneva, Elena Y. Zlatnik, Aleksey Yu Maksimov, Inna A. Novikova, Alexander B. Sagakyants, Sofya V. Timofeeva, Anna S. Goncharova, Anastasia V. Galina, Svetlana A. Appolonova, Pavel A. Markin, Valentin V. Makarov, Sergey M. Yudin, Anton A. Keskinov, Sergei A. Roumiantsev, Oleg I. Meshkov

“…For several ARs, there were strong positive and negative correlations in both faeces and serum with immune cells and these interrelationships differed between the therapy-responsive and nonresponsive groups. …”
Get full text

Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways by Fuxia Hu, Chao Liu, Fengqin Wang, Changxin Zhou, Maotong Zhu, Dongxiao Sun-Waterhouse, Zhaosheng Wang

“…The extract at 30 μg/mL was most potent and enabled most cells in normal morphology under LPS stimulation without causing cytotoxicity. …”
Get full text

Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial by Marlieke Visser, Hans W. M. Niessen, Wouter E. M. Kok, Riccardo Cocchieri, Willem Wisselink, Paul A. M. van Leeuwen, Bas A. J. M. de Mol

“…Myocardial atrial tissue was sampled before and after revascularization and was analysed immunohistochemically, subdivided into cardiomyocytic, fatty, and fibrotic areas. Inflammatory cells, especially leukocytes, were present in cardiac tissue in all study groups. …”
Get full text

Primary Vaginal Myeloid Sarcoma: A Rare Case Report and Review of the Literature by Gaurang Modi, Irappa Madabhavi, Harsha Panchal, Apurva Patel, Asha Anand, Sonia Parikh, Pritam Jain, Swaroop Revannasiddaiah, Malay Sarkar

“…Myeloid sarcoma (chloroma, granulocytic sarcoma, or extramedullary myeloid tumour) is an extramedullary mass forming neoplasm composed of myeloid precursor cells. It is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukemia. …”
Get full text

Harnessing nanotechnology for cancer treatment by Jiajun Zhu, Jiajun Zhu, HaeJu Lee, HaeJu Lee, Ruotong Huang, Ruotong Huang, Jianming Zhou, Jingjun Zhang, Xiaoyi Yang, Wenhan Zhou, Wangqing Jiang, Shuying Chen

“…Furthermore, nanotechnology-based therapeutic strategies, including photothermal therapy, gene therapy and immunotherapy are offering novel ways to combat cancer by selectively targeting tumor cells and enhancing the immune response. Nevertheless, despite these progressions, obstacles still persist, particularly in the clinical translation of these technologies. …”
Get full text

Morphology and Immunoexpression of Selenoproteins in Term Placenta of Alpaca (<i>Vicugna pacos</i>) from the Peruvian Andes by Miluska Beatriz Navarrete Zamora, Francisco Acuña, Mônica Duarte da Silva, Thamires Santos-Silva, Matheus Henrique Herminio Garcia, Rodrigo da Silva Nunes Barreto, Alberto Sato Sato, Claudio Gustavo Barbeito, Maria Angelica Miglino

“…The chorion showed simple cuboidal epithelium with binucleated cells, a subepithelial mesenchyme rich in blood capillaries (area: 124.90 ± 9.82 µm²), and type III collagen fibers. …”
Get full text

Structure–Antioxidant Activity Relationship of Polysaccharides Isolated by Microwave/Ultrasonic-Assisted Extraction from <i>Pleurotus ferulae</i> by Hongjin Zhou, Zhongxiong Fan, Yuan Li, Xuelian Liu, Bo Wang, Jianguo Xing, Jiang He, Ruifang Zheng, Jinyao Li

“…Furthermore, antioxidant analysis revealed that high concentration (at concentrations above 600 μg/mL) MU-PFPS demonstrated stronger protective effects against oxidative damage in RAW264.7 cells than U-PFPS did. Collectively, these data suggest that lower molecular weight and higher branching degree of polysaccharides at appropriate concentrations may correlate with enhanced antioxidant enzyme activities. …”
Get full text

The <i>OsGATA</i> gene family as a promising candidate for applying the CRISPR/Cas genome editing technology to improve the nutritional and yield qualities of rice (<i>Oryza sativa... by E. A. Nesterova, N. A. Shvachko

“…Photosynthetic activity affects all metabolic processes in plant cells. The genes involved in photosynthesis, in their turn, are regulated by differentially expressed genes associated with circadian rhythms. …”
Get full text

PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response by Ling Cheng, Ian Meliala, Yidi Kong, Jingyuan Chen, Christopher G Proud, Mikael Björklund

“…Real-time interaction analysis using luminescence complementation in live cells revealed an interaction between PEBP1 and eIF2α, which was disrupted by eIF2α S51 phosphorylation. …”
Get full text

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japane... by Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh

“…The 8-week NMN supplementation regimen was well-tolerated; NAD+ levels in peripheral blood mononuclear cells increased over the course of NMN administration. …”
Get full text

Silica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil by Marcos César Santos de Castro, Lucas de Carvalho Costa, Kaio Cezar Rodrigues Salum, Hermano Albuquerque de Castro, Patrícia Canto Ribeiro, Walter Costa, Angela Santos Ferreira Nani, Fabiana Barzotto Kohlrausch

“…We extracted DNA from buccal cells and assessed TL by multiplex quantitative polymerase chain reaction. …”
Get full text

Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

“…Macrophages play a very important role in host defense and in iron homeostasis by engulfing senescent red blood cells and recycling iron. Hepcidin is the master iron regulating hormone that limits dietary iron absorption from the gut and limits iron egress from macrophages. …”
Get full text

Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation by Yu Huang, Yu Huang, Yu Huang, Lu Li, Lu Li, Ran Chen, Ran Chen, Lang Yu, Lang Yu, Shunkai Zhao, Yanjun Jia, Yanjun Jia, Ying Dou, Ying Dou, Ying Dou, Zhiyong Zhang, Zhiyong Zhang, Yunfei An, Yunfei An, Xuemei Tang, Xuemei Tang, Xiaodong Zhao, Xiaodong Zhao, Lina Zhou

“…Additionally, the frameshift variant CXCR4V340fs led to impaired receptor downregulation in patients’ PBMCs, and in HEK293T cells transfected with the variant plasmids.ConclusionsOur study provided detailed clinical features of four CXCR4V340fs WHIM patients from one Chinese family who presented atypical phenotype and enrich the spectrum of WHIM syndrome.…”
Get full text

Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity by Salome’ V. Ibba, Mohamed A. Ghonim, Kusma Pyakurel, Matthew R. Lammi, Anil Mishra, A. Hamid Boulares

“…We show, for the first time, that iNOS is highly expressed in peripheral blood mononuclear cells (PBMCs) of asthmatics with uncontrolled disease, which did not correspond to protein nitration. …”
Get full text

Development and validation of a prognostic signature of breast cancer based on drug absorption, distribution, metabolism and excretion (ADME)-related genes by Zhixuan Wu, Yangyang Guo, Liangchen Qu, Xiaowu Wang, Hewei Zhang

“…The variation in both the infiltration of immune cells and the expression of immune-related genes in the tissues differed among the two groups. …”
Get full text

A Second-Iteration Square Koch Fractal Slot Antenna for UHF Downlink Telemetry Applications in CubeSat Small Satellites by Jorge Simon, Jorge Flores-Troncoso, Jose Luis Alvarez-Flores, Leonel Soriano-Equigua, Marco Cardenas-Juarez, Armando Arce, Edgar Briones, Jorge Sosa-Pedroza

“…The contribution of this work consists in the use of a fractal geometry to construct a low-cost slot antenna working at UHF frequencies over the limited area of the CubeSat faces and in order to optimize the area for an eventual coexistence with solar cells.…”
Get full text

All-round enhancement induced by oxophilic single Ru and W atoms for alkaline hydrogen oxidation of tiny Pt nanoparticles by Wensheng Jiao, Zhanghao Ren, Zhibo Cui, Chao Ma, Ziang Shang, Guanzhen Chen, Ruihu Lu, Tao Gan, Ziyun Wang, Yu Xiong, Yunhu Han

“…Abstract Anion exchange membrane fuel cells (AEMFCs) are one of the ideal energy conversion devices. …”
Get full text

Magnifying Endoscopic Features of Follicular Lymphoma Involving the Stomach: A Report of Two Cases by Masaya Iwamuro, Katsuyoshi Takata, Seiji Kawano, Nobuharu Fujii, Yoshiro Kawahara, Tadashi Yoshino, Hiroyuki Okada

“…Disappearance of gastric pits in the latter case seems to result from loss of epithelial cells, probably due to chronic inflammation. In both cases, branched abnormal vasculature was observed. …”
Get full text

Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer by Hamiyet Donmez-Altuntas, Fahri Bayram, Nazmiye Bitgen, Sibel Ata, Zuhal Hamurcu, Gulden Baskol

“…The micronucleus (MN) frequency (chromosomal DNA damage), apoptotic and necrotic cells (cytotoxicity), and plasma 8-OHdG levels (oxidative DNA damage) were significantly higher among patients with multinodular goiter. …”
Get full text