Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation by Khalaf Reema Abu, Alwarafi Ebtisam, Sabbah Dima

“…Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the incretin levels, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic poly-peptide (GIP), leading to insulin secretion from pancreatic beta cells. In the present study, nine 1,4-bis(phenylsulfonyl) piperazine derivatives 1a-i were synthesized and identified using 1H NMR, 13C NMR, MS and IR spectroscopies. …”
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Ocular Hypertropia Mimicking Inferior Rectus Palsy as an Atypical Presentation of Parameningeal Rhabdomyosarcoma in a Child by Alhodaly H, Aldohayan N, Alhamazani M, Alanazy T, Bazuhair MS

“…Hind Alhodaly, Noura Aldohayan, Manal Alhamazani, Thamer Alanazy, Muaz Saeed Bazuhair Department of Pediatric Ophthalmology, Prince Sultan Military Medical City, Riyadh, Saudi ArabiaCorrespondence: Manal Alhamazani, Department of Pediatric Ophthalmology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia, Email Manalalhamazany1997@gmail.comIntroduction: Rhabdomyosarcoma (RMS) originates from undifferentiated mesenchymal cells that give rise to striated muscles. The symptoms of para-meningeal RMS often resemble those of allergic rhinosinusitis, including nasal congestion, mucus discharge, headache, and occasional nosebleeds. …”
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Hep-2000 indirect immunofluorescence assay – An emerging screening tool for detection of antinuclear autoantibodies in various connective tissue disorders by Arpita Singh, Shilpi Sahu, Neha R. Jadhav, Navdeep Kaur

“…Materials and Methods: For IFA, patient’s sera is incubated with substrate cells, and bound antibodies are detected by incubation with a dye-conjugated anti-human immunoglobulin which are visualized by fluorescent microscopy and different ANA titres and patterns were analysed. …”
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Regulation of histone H4 acetylation in the CNS and defensive behavior command neurons of the mollusk Helix mediated by serotonin and neuropeptide FMRFamide by L. N. Grinkevich, T. G. Zachepilo

“…Presently, scientists’ attention is focused on changes in the levels of histone modifications (mainly acetylation and methylation) in the chromatin of CNS cells tested in various experimental models. Owing to their relatively simple CNSs, mollusks are among the most popular models. …”
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Etudes menées sur les sculptures d'Auvergne en bois polychromé by Marie-Blanche Potte, Dominique Faunières, Agnès Blossier, Lucretia Kargère

“…Tandis que les sculptures conservées dans les musées ont acquis un certain prestige, celles qui sont conservées dans leurs églises restent moins connues et ont rarement fait l’objet d’études techniques. …”
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Design Considerations for Borehole Thermal Energy Storage (BTES): A Review with Emphasis on Convective Heat Transfer by Helge Skarphagen, David Banks, Bjørn S. Frengstad, Harald Gether

“…Storage efficiency may be dramatically reduced in cases where (i) natural groundwater advection through the BTES removes stored heat, (ii) extensive free convection cells (thermosiphons) are allowed to form, and (iii) poor BTES design results in a high surface area/volume ratio of the array shape, allowing high conductive heat losses. …”
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The small GTPase MRAS is a broken switch by Gabriela Bernal Astrain, Regina Strakhova, Chang Hwa Jo, Emma Teszner, Ryan C. Killoran, Matthew J. Smith

“…Acquisition of NMR spectra from isotopically labeled MRAS in live cells validated the GTPase remains fully GDP-loaded, even a supposed activated mutant. …”
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HER2 Negative Mammary Paget’s Disease or In Situ Melanoma? A Case Report and Review of the Literature by Luana-Andreea Boșoteanu, Mariana Așchie, Cristian Ionuţ Orǎșanu, Mădălina Boșoteanu

“…In the case of similar morphoimmunohistochemical aspects, significant expression of Ki-67 signals MPD, an immunoreactivity that helped distinguish the cellular population from Toker cells. The great similarity of MPD with other benign and malignant cutaneous tumors might determine delay or misdiagnosis. …”
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A Design Procedure and Control Method for Improving Efficiency of a Family of Resonant Converters Over Wide Operating Conditions by Jasem Shahsevani, Reza Beiranvand

“…They find numerous applications in various industries such as electric vehicles, battery chargers, and photovoltaic cells. However, low efficiency under light-load or no-load conditions is one of their main challenges, which arises when their switching frequencies deviate significantly from their resonance frequencies during output voltage regulation, resulting in high circulating currents and switching harmonics values. …”
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Effect of physical activity on structural asymmetry of mouse hippocampus by T. A. Zapara, A. V. Romashchenko, A. L. Proskura, A. S. Ratushnyak

“…Despite considerable efforts, little is known about the fnal fate of these cells, the functional signifcance of their connections and the regulation of their development. …”
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Local field potentials in a pre-motor region predict learned vocal sequences. by Daril E Brown, Jairo I Chavez, Derek H Nguyen, Adam Kadwory, Bradley Voytek, Ezequiel M Arneodo, Timothy Q Gentner, Vikash Gilja

“…There is a rich history of using local field potentials (LFP) to extract information about behavior that extends beyond the contribution of individual cells. These signals have the advantage of being stable over longer periods of time, and they have been used to study and decode human speech and other complex motor behaviors. …”
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The histological and chemical changes occured through the preparation stages of the pastrami produced by using automatic injection and press-machines by Mine Balıkçıer, Şahsene Anar, Hatice Erdost

“…In the meat stage glycosaminoglicans accumulated in a few cells, but they disappeared after this stage. The observations on the sections, those were prepared from the pastrami sections taken at the end of each stage showed that no changes occured in the content and structure of lipid deposits. …”
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AI-Based Screening Method for Early Identification of Invasive Ductal Carcinoma in Breast Cancer by Dominik Jánošík, Sila Yavuz

“…Subsequently, we employed the U-Net network for image segmentation to distinguish cancer cells from healthy breast tissue and eliminate outlier data. …”
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An Optimized Anti-adherence and Anti-biofilm Assay: Case Study of Zinc Oxide Nanoparticles versus MRSA Biofilm by Hefa Mangzira Kemung, Loh Teng-Hern Tan, Kooi Yeong Khaw, Yong Sze Ong, Chim Kei Chan, Darren Yi Sern Low, Siah Ying Tang, Bey-Hing Goh

“…The ZnO-NPs effectively prevented attachment of bacterial cells onto walls of wells with 51.69 ± 2.55% at the highest concentration tested (65.4 µg/mL). …”
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Antibacterial and quorum sensing regulatory activities of some traditional Eastern-European medicinal plants by Tolmacheva Anna A., Rogozhin Eugene A., Deryabin Dmitry G.

“…The objective of this study was to screen extracts of twenty Eastern European medicinal plants, using wild-type and reporter Chromobacterium violaceum bioassays, for novel components that target bacterial cells and their quorum sensing (QS) communication systems. …”
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Numerical Study of the Aerodynamics of a Hovering Hummingbird’s Wing with Dynamic Morphing by Yuanbo Dong, Bifeng Song, Dong Xue, Yuanbo Li, Wenqing Yang

“…In numerical simulations, boundary-based smoothing and overset methodologies were used in combination to update the interior nodes of cells in the computational domain, allowing those nodes to accommodate the motion of the flexible wall. …”
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Advanced Techniques for Glucose Oxidase Immobilization: Evolution, Computational Integration, and Biomedical Applications by G Sreenivasulu, R. Ramakoteswara Rao

“…Incorporating nanomaterials and computational methods, such as molecular modeling and simulations, further optimizes the immobilization process, providing insights into enzyme-support interactions and improving performance in applications like biosensors, biofuel cells, and drug delivery systems. The study also explores future trends, including artificial intelligence and innovative support materials, to drive advancements in glucose oxidase immobilization. …”
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Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy by Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu

“…Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. …”
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Strain-limited biofilm regulation through the Brg1-Rme1 circuit in Candida albicans by Min-Ju Kim, Aaron P. Mitchell

“…ABSTRACT Prominent virulence traits of Candida albicans include its ability to produce filamentous hyphal cells and grow as a biofilm. These traits are under control of numerous transcription factors (TFs), including Brg1 and Rme1. …”
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Exploring the inhibitory potential of xanthohumol on MEK1/2: a molecular docking and dynamics simulation investigation by Zohreh Gholizadeh Siahmazgi, Shiva Irani, Ali Ghiaseddin, Fereshteh Soutodeh, Zahra Gohari, Jaber Afifeh, Amirreza Pashapouryeganeh, Hilda Samimi, Mahmood Naderi, Parviz Fallah, Vahid Haghpanah

“…Conclusion and implications: The findings of the study suggested that Xn, as a novel bioactive compound, potentially inhibits the MEK1/2 function in cancer cells.…”
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