A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disea... by Shankar J. Chinta, Subramanian Rajagopalan, Abirami Ganesan, Julie K. Andersen

“…DHB significantly attenuated LPS-mediated induction of nitric oxide synthase and pro-inflammatory cytokines in murine BV2 microglial cells in vitro in conjunction with reduced ROS production and activation of NFκB and MAPK pathways possibly due to up-regulation of HO-1 levels. …”
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Higher Risk Myelodysplastic Syndromes in Patients with Well-Controlled HIV Infection: Clinical Features, Treatment, and Outcome by Bradley T. Williamson, Heather A. Leitch

“…A 56-year-old woman presented with cytopenias. CD4 was 1310 cells/mL and HIV viral load <40 copies/mL. Bone marrow biopsy showed RCMD and karyotype included del(5q) and del(7q); IPSS was intermediate-2 risk. …”
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Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation by Shuang Lin, Shanshan Dai, Jiahui Lin, Xiaohe Liang, Weiqi Wang, Weijian Huang, Bozhi Ye, Xia Hong

“…Our study investigated that hypertrophy and fibrosis can be induced after being treated with Ang II in cardiomyocytes (H9c2 cells and primary rat cardiomyocytes) and C57BL/6J mice. …”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…A high degree of selectivity of antiparasitic activity over toxicity to mammalian cells was observed. Afterwards, GV and TPM 6 were tested in a topical formulation in mice infected with L. …”
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Interleukin-15 and Tumor Necrosis Factor-α in Iraqi Patients with Alopecia Areata by Zainab A. Kamil, Galawish A. Abdullah, Haider Hashim Zalzala

“…Most evidence supports the hypothesis that it is disease of the hair follicle of autoimmune nature mediated by T-cells, with important cytokine role. Objective of the Study. …”
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Effect of Tuina Manipulation on the Expression of Desmin in Gastrocnemius of Rats with Sciatic Nerve Injury by Xianyu FU, Junpeng ZHANG, Ziwei SONG, Jiaqi WANG, Yanan GUO, Ying MA, Juntao YAN, Shujie MA

“…The expression of Desmin in the Tuina group was higher at the 4,8,12 weeks after successful modeling (<italic>P</italic>&lt;0.05), lower at the 16 weeks after successful modeling (<italic>P</italic>&lt;0.05).Conclusion:Tuina can promote the recovery of gastrocnemius atrophy after sciatic nerve injury, and its mechanism may promote the differentiation and maturation of muscle satellite cells by up-regulating the expression of Desmin.…”
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Identification and characterization of the COPII vesicle‐forming GTPase Sar1 in Chlamydomonas by Kin Pan Chung, Daniel Frieboese, Florent Waltz, Benjamin D. Engel, Ralph Bock

“…Abstract Eukaryotic cells are highly compartmentalized, requiring elaborate transport mechanisms to facilitate the movement of proteins between membrane‐bound compartments. …”
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Differences in gene expression between high and low tolerance rainbow trout (Oncorhynchus mykiss) to acute thermal stress. by Leah A Turner, Anne A Easton, Moira M Ferguson, Roy G Danzmann

“…Our results suggest that high tolerance fish engaged in processes that supported the prevention of further damage by enhancing repair pathways, whereas low tolerance fish were more focused on replacing damaged cells and their structures.…”
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Development of Thermoresponsive Composite Hydrogel Loaded with Indocyanine Green and Camptothecin for Photochemotherapy of Skin Cancer After Surgery by Yu-Hsiang Lee, Chieh-Lin Chung

“…Furthermore, ICHHPG may provide a remarkably enhanced cancericidal effect compared to the equal concentration of free ICG (≤10 μM) or CPT (≤1000 μM) alone, and more than 95% of cancer cells can be destroyed as the intra-gel doses of ICG/CPT were elevated to 10/800 μM. …”
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Hagiografie şi ideologie by Cristina Balinte

“…Nous allons poursuivre d’abord les acceptions principales données au genre hagiographique, en prenant aussi en discussion la pertinence d’encadrement dans la catégorie de la biographie des gens exceptionnels ou celle du discours sur les vertus, ce qui porte le nom d’arétologie. …”
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FIRM image analysis: A machine learning workflow for quantifying extracellular matrix components from electron microscopy images. by Nicholas T Gigliotti, Justin Lee, Emily H Mang, Giancarlo R Zambrano, Mitra L Taheri

“…The extracellular matrix (ECM) is a complex network of biomolecules that plays an integral role in the structure, processes, and signaling mechanisms of cells and tissues. Identifying and quantifying changes in these matrix components provides insight into the mechanisms behind specific tissue remodeling processes; however, quantifying these changes is challenging due to difficult imaging conditions, complexity of the ECM, and the subtlety of these changes. …”
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Silver Nanoparticles in Antifungal Applications: A Comparison of Biosynthesized and Physical Synthesized Nanoparticles on Paper-Biodegrading Fungi by Akram Kheiri, Parisa Mohammadi, Parinaz Ghadam

“…The biological methods involved the use of extracts from Juglans regia green husk, Malva sylvestris leaves, and cyanobacterial cells. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the AgNPs were determined using standard protocols.Results: The MIC values of the AgNPs synthesized from different sources exhibited varying degrees of antifungal activity against the tested fungi. …”
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Perbandingan Jumlah Trombosit pada Pasien COVID-19 dengan Kadar Glukosa yang Berbeda by Imanta Alifia Octavira, Agrijanti Agrijanti, Lalu Srigede, Siti Zaetun

“…Thrombocytopenia in COVID-19 patients occurs through a variety of mechanisms, such as uncontrolled production of cytokines destroying bone marrow progenitor cells, direct inhibition of hematopoiesis viral infection of the bone marrow, increase in autoantibodies and immune complexes that cause platelet destruction, and lung injury that causes platelet aggregation and consumption of platelets so that platelets in the circulation are reduced. …”
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Microimaging Characterization of a B16-F10 Melanoma Metastasis Mouse Model by Christopher T. Winkelmann, Said Daibes Figueroa, Tammy L. Rold, Wynn A. Volkert, Timothy J. Hoffman

“…Juvenile female C57BL/6 mice were injected intravenously with syngenic B16-F10 melanoma cells. Serial micro-CT imaging studies were performed on anesthetized mice. …”
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Endoscopic Appearance of Oropharyngeal and Upper GI Kaposi’s Sarcoma in an Immunocompromised Patient by Umar Darr, Anas Renno, Zubair Khan, Turki Alkully, Maitham A. Moslim, Sehrish Kamal, Ali Nawras

“…Biopsy of the soft palate lesions showed proliferation of neoplastic spindle shaped cells arranged in bundles with slit-like capillary spaces containing erythrocytes consistent with Kaposi’s sarcoma. …”
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The Effect of an Aqueous Extract of Teucrium polium on Glutathione Homeostasis In Vitro: A Possible Mechanism of Its Hepatoprotectant Action by Stella Shtukmaster, Predrag Ljubuncic, Arieh Bomzon

“…The effects of increasing concentrations (0.01–1 mg/mL) of aqueous extract of T. polium were assessed in cultured HepG2 cells following 24 hours incubation on (1) cellular integrity using (a) the Trypan blue exclusion assay, (b) the [di-methylthiazol-2yl]-2,5-diphenyl-tetrazoliumbromide (MTT) assay, and (c) the lactate dehydrogenase (LDH) assay; (2) glutathione redox state; and (3) glutathione peroxidase and glutathione reductase activities using a repeated measures experimental design. …”
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Electroanalytical Methods as a Tool for Determining the Antioxidant Capacity in Blood Samples by Fernanda Gonçalves de Oliveira, Thiago da Silveira Alvares, Rodrigo de Siqueira Melo

“… Aerobic metabolism is an essential process for energy production in cells, but it also generates reactive oxygen species (ROS), which, in excess, can cause cellular damage and contribute to the development of various diseases, such as cardiovascular diseases, cancer, and neurodegenerative disorders. …”
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Microenvironment Elements Involved in the Development of Pancreatic Cancer Tumor by Katarzyna Gardian, Sława Janczewska, Marek Durlik

“…Also we found that active MMP2 was present at all stages of tumor while active MMP9 just at more advanced tumors. Abundant immune cells infiltration was distinctive for tumor tissue, especially macrophages were infiltrating tumor tissue. …”
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Insilico targeting of virus entry facilitator NRP1 to block SARS-CoV2 entry. by Nousheen Bibi, Maleeha Shah, Shahzad Khan, Muhammad Shahzad Chohan, Mohammad Amjad Kamal

“…SARS-CoV-2, the virus responsible for COVID-19, utilizes the spike (S) protein to attach to and enter host cells. Recent studies have identified neuropilin-1 (NRP1) as a crucial facilitator for the entry of SARS-CoV-2. …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…The authors investigated the effects of psychotropics on pathobiological proteins, proteasomal activity, mitochondrial functions, apoptosis, neuroinflammation, trophic factors, stem cells, and neurogenesis. Only findings replicated in at least 2 studies were considered for these actions. …”
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