VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis by Genxiang Rong, Zhenyu Zhang, Wenjing Zhan, Minnan Chen, Jingjing Ruan, Cailiang Shen

“…To address the lack of studies focused on synovial cells in OA, we evaluated the expression patterns and roles of the MAPK signaling pathway components in OA synovial tissues using bioinformatics. …”
Get full text

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…Excessive fat storage in obesity promotes the progressive infiltration of immune cells into adipose tissue, resulting in the release of pro-inflammatory factors such as cytokines and adipokines. …”
Get full text

Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCO3 Nanocrystals by Francesca Baldassarre, Viviana Vergaro, Federica De Castro, Francesca Biondo, Gian Paolo Suranna, Paride Papadia, Francesco P. Fanizzi, Domenico Rongai, Giuseppe Ciccarella

“…Furthermore, nanoformulations demonstrated a good antiproliferative activity in neuroblastoma and breast cancer cells carrying out a higher cytotoxic effect respect to free extract, confirming a crucial role of nanocarriers. …”
Get full text

A Novel Reduced Component High Boost Multilevel Inverter by Pratik Kar, Rachita Ruchismita Sarangi, Durgesh Prasad Bagarty, Prakash Kumar Ray, Asit Mohanty, Manzoore Elahi M. Soudagar, Yasser Fouad, Sagar Shelare

“…This multilevel inverter produces a multi-stepped output voltage based on series connection of power cells making the use of standard low voltage components. …”
Get full text

Dynamic Metabolic Footprinting Reveals the Key Components of Metabolic Network in Yeast Saccharomyces cerevisiae by Pramote Chumnanpuen, Michael Adsetts Edberg Hansen, Jørn Smedsgaard, Jens Nielsen

“…Metabolic footprinting offers a relatively easy approach to exploit the potentials of metabolomics for phenotypic characterization of microbial cells. To capture the highly dynamic nature of metabolites, we propose the use of dynamic metabolic footprinting instead of the traditional method which relies on analysis at a single time point. …”
Get full text

The Protective Effects of 18β-Glycyrrhetinic Acid on Imiquimod-Induced Psoriasis in Mice via Suppression of mTOR/STAT3 Signaling by Haiming Chen, Huazhen Liu, Bin Tang, Yuchao Chen, Ling Han, Jingjie Yu, Yuhong Yan, Chuanjian Lu

“…GA also suppressed the mRNA levels of IL-6, TNF-α, IL-17, IL-23, and IL-1β in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens. Its anti-inflammatory and immunomodulatory activities may be related to its suppression of the STAT3 and mTOR signaling. …”
Get full text

Diet Supplementation Influences Ghrelin System Expression in the Skin Appendages of the Sheep by Margherita Maranesi, Cecilia Dall’Aglio, Sara Moscatelli, Elisa Palmioli, Paola Coliolo, Daniele Marini, Gabriella Guelfi, Paola Scocco, Francesca Mercati

“…Indeed, the ligand was localized in the hair follicles whereas the receptor was also observed in sweat glands and smooth muscle cells. The expression of both genes was significantly higher in the Exp group (3.6 and 2.9 folds respectively, <i>p</i> < 0.05) compared with the MxF group. …”
Get full text

Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery by Cristina Mormile, Ocsana Opriș, Stefano Bellucci, Ildiko Lung, Irina Kacso, Alexandru Turza, Adina Stegarescu, Septimiu Tripon, Maria-Loredana Soran, Ioana Bâldea

“…Finally, cytotoxicity tests showed the biocompatibility of the system in normal human cells. These findings suggest that graphene-enhanced alginate matrices have significant potential for controlled drug delivery applications.…”
Get full text

Abundance and Symbiotic Rhizobia Colonizing Soybean (Glycine max) in Soils of Kakamega County, Western Kenya by Samuel Mulama, Rose Onamu, Fredrick Odongo, John Muoma

“…Rhizobia number in the soil collected from the six regions varied from 2.5 × 102 to 3.12 × 103 cells·g− soil. Thirty isolates from the soil collected in the four regions were tested for efficiency using soybean as the trap plant in Leonard jars containing sterilized vermiculite irrigated with nitrogen-free media. …”
Get full text

Specific detection of pigeon parvovirus with TaqMan real-time PCR technology by Cuiteng Chen, Chunhua Zhu, Shuyu Chen, Zhen Chen, Huanru Fu, YuYi Chen, Mengyan Zhang, Wenyu Zhang, Yu Huang, Longfei Cheng, Chunhe Wan

“…Owing to the failure to propagate PiPV in embryos and cells, knowledge of PiPV replication mechanisms in birds still needs further study. …”
Get full text

Mechanisms and environmental factors shaping the ecosystem of brain macrophages by Silvia Penati, Simone Brioschi, Zhangying Cai, Claudia Z. Han, Claudia Z. Han, Marco Colonna, Marco Colonna

“…Brain macrophages encompass two major populations: microglia in the parenchyma and border-associated macrophages (BAMs) in the extra-parenchymal compartments. These cells play crucial roles in maintaining brain homeostasis and immune surveillance. …”
Get full text

Fully integrated wearable control system for micro/nanorobot navigation by Zhanxiang Zhang, Lin Wang, Fengqi Jiang, Shimin Yu, Fengtong Ji, Tianhao Sun, He Zhang, Yanhe Zhu, Hao Chang, Tianlong Li, Jie Zhao

“…Such a novel, feasible control strategy was validated in the biological experiment in which cancer cells were targeted and killed by photothermal therapy using micro/nanorobots and integrated control platform. …”
Get full text

An interpretable and transparent machine learning framework for appendicitis detection in pediatric patients by Krishnaraj Chadaga, Varada Khanna, Srikanth Prabhu, Niranjana Sampathila, Rajagopala Chadaga, Shashikiran Umakanth, Devadas Bhat, K. S. Swathi, Radhika Kamath

“…According to the explainers, length of stay, means vermiform appendix detected on ultrasonography, white blood cells, and appendix diameter were the most crucial markers in detecting appendicitis. …”
Get full text

Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis by Min Wei, Qiaoji Jiang, Shuang Bian, Pengzhao Chang, Bangbang Li, Changzhou Shi, Yangang Zhu, Yanchen Wang, Pingfu Hou, Jingjing Li

“…Abstract With the progress of atherosclerosis (AS), the arterial lumen stenosis and compact plaque structure, the thickening intima and the narrow gaps between endothelial cells significantly limit the penetration efficiency of nanoprobe to plaque, weakening the imaging sensitivity and therapy efficiency. …”
Get full text

The Response Regulator OmpR Negatively Controls the Expression of Genes Implicated in Tilimycin and Tilivalline Cytotoxin Production in <i>Klebsiella oxytoca</i> by Ramón G. Varela-Nájera, Miguel A. De la Cruz, Jorge Soria-Bustos, Carmen González-Horta, Ma Carmen E. Delgado-Gardea, Jorge A. Yáñez-Santos, María L. Cedillo, Hidetada Hirakawa, James G. Fox, Blanca Sánchez-Ramírez, Miguel A. Ares

“…Notably, in the absence of OmpR, we observe a significant increase in cytotoxic effects on Caco-2 cells. These observations identify OmpR as a crucial negative transcription regulator for both operons, effectively managing the release of these cytotoxins. …”
Get full text

Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2 by Qi Dong, Haoyuan Fu, Wenxiao Li, Xinyu Ji, Yingchao Yin, Yiran Zhang, Yanbo Zhu, Guoqiang Li, Huiyang Jia, Heng Zhang, Haofei Wang, Jinglue Hu, Ganggang Wang, Zhihao Wu, Yingze Zhang, Sujuan Xu, Zhiyong Hou

“…In this study, in vitro and in vivo models revealed delayed bone development and an osteoporosis phenotype in mice lacking FXR in bone marrow mesenchymal stem cells (BMSCs) and osteoblasts due to impaired osteoblast differentiation. …”
Get full text

Seasonality Influence on Biochemical and Hematological Indicators of Stress and Growth of Pirarucu (Arapaima gigas), an Amazonian Air-Breathing Fish by Rosiely Felix Bezerra, Maria do Carmo Figueiredo Soares, Athiê Jorge Guerra Santos, Elba Verônica Matoso Maciel Carvalho, Luana Cassandra Breitenbach Barroso Coelho

“…Seasonality effect analysis was performed on biochemical (lectin activity, lactate dehydrogenase, and alkaline phosphatase activities) and hematological (total count of red blood cells, hematocrit, hemoglobin, and hematimetric Wintrobe indexes) stress indicators, as well as on growth and wellbeing degree expressed by pirarucu condition factor developed in captivity. …”
Get full text

Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX... by Zitian Gao, Gaorui Wang, Yujie Chen, Wuke Yuan, Jun Cai, Aiping Feng, Jie Fang, Qi Xu, Xiaojun Wu

“…TFA also prevented 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in SH-SY5Y cells, by increasing GSH and GSH/GSSG ratio, and reducing reactive oxygen species. …”
Get full text

Two Cases of Lacaziosis in Bottlenose Dolphins (Tursiops truncatus) in Japan by Keiichi Ueda, Ayako Sano, Jyoji Yamate, Eiko Itano Nakagawa, Mitsuru Kuwamura, Takeshi Izawa, Miyuu Tanaka, Yuko Hasegawa, Hiroji Chibana, Yasuharu Izumisawa, Hirokazu Miyahara, Senzo Uchida

“…The granulomatous skin lesions from the present cases were similar to those found in animals from endemic areas, containing multiple budding and chains of round yeast cells and positive in the immune-staining with anti-Paracoccidioides brasiliensis serum which is a fungal species related to L. loboi; however, the gp43 gene sequences derived from the present cases showed 94.1% homology to P. brasiliensis and 84.1% to L. loboi. …”
Get full text

Decreased Interleukin-4 Release from the Neurons of the Locus Coeruleus in Response to Immobilization Stress by Hyun-ju Lee, Hyun-Jung Park, Angela Starkweather, Kyungeh An, Insop Shim

“…Glucocorticoid receptor (GR), TH, and IL-4-expressing cells were localized in identical neurons of the LC, indicating that hypothalamic-pituitary-adrenal- (HPA-) axis and sympathetic-adrenal-medullary- (SAM-) axis might be involved in IL-4 secretion in the stress response. …”
Get full text