Effect of Toll-Like Receptor 4 on Synovial Injury of Temporomandibular Joint in Rats Caused by Occlusal Interference by Jingjing Kong, Yingying Yang, Shuzhen Sun, Jianli Xie, Xuefen Lin, Ping Ji

“…Some investigations suggested that the increasing expression of IL-1β secreted by synovial lining cells plays an important role in synovial inflammation and cartilage destruction in TMJ. …”
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Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing by Enyou Jin, Yusheng Yang, Shengjie Cong, Dengke Chen, Ruixiong Chen, Jun Zhang, Yanjun Hu, Weini Chen

“…Lemon exosomes regulated the polarization reprogramming of macrophages, promoted the proliferation and migration of vascular endothelial cells and fibroblasts, and thus promoted the healing of diabetic wounds. …”
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Elevated Transforming Growth Factor-β2 in the Aqueous Humor: A Possible Explanation for High Rate of Capsular Contraction Syndrome in High Myopia by Keke Zhang, Xiangjia Zhu, Minjie Chen, Xinghuai Sun, Jin Yang, Peng Zhou, Yi Lu

“…Histopathological analysis revealed proliferation of fibroblast-like lens epithelial cells on the shrunken anterior capsule, labeled with TGF-β2 antibodies. …”
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Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

“…Although KPNA2 knockdown failed to impair the vitality and migration ability of PDAC cells in vitro, the in vivo tumor growth was significantly impeded and the expression of immune checkpoint ligand PD-L1 was reduced by silencing KPNA2. …”
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Separating and Characterizing Functional Nitrogen Degraders via Magnetic Nanoparticle-Mediated Isolation by Yujiao Sun, Meng Yin, Danyang Zheng, Lei Wang, Xiaohui Zhao, Jie Li

“…In this study, the composition and properties of magnetic nanoparticles (MNPs) were characterized by a number of techniques, indicating that MNPs have characteristics such as microinterfaces and can be efficiently fixed on the surface of microbial cells. It also introduced the MMI technology in activated sludge after stable long-term treatment. …”
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Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

“…Produced by immune and epithelial cells, they serve as natural defenses against a wide range of pathogens, including bacteria, viruses, and fungi. …”
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Peptide Aptamer–Paclitaxel Conjugates for Tumor Targeted Therapy by Xinyang Shen, Yuan Ma, Hang Luo, Razack Abdullah, Yufei Pan, Yihao Zhang, Chuanxin Zhong, Baoting Zhang, Ge Zhang

“…<b>Background/Objectives</b>: Traditional paclitaxel therapy often results in significant side effects due to its non-specific targeting of cancer cells. Peptide aptamer–paclitaxel conjugates present a promising alternative by covalently attaching paclitaxel to a versatile peptide aptamer via a linker. …”
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D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming by Fengchao Lang, Karambir Kaur, Haiqing Fu, Javeria Zaheer, Diego Luis Ribeiro, Mirit I. Aladjem, Chunzhang Yang

“…CTCF depletion leads to the disruption of chromatin organization around the DNA damage sites, which abolishes the recruitment of essential DNA damage repair proteins BRCA2 and RAD51, as well as impairs homologous repair in the IDH mutant cancer cells. These findings provide evidence that CTCF-mediated chromatin interactions play a key role in DNA damage repair proceedings. …”
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Comparison of Symmetric and Asymmetric Copper Tubing Designs for Improved Cooling in PV/T Systems by Riad Ayoub, Amiry Houssam, Touhtouh Samira, Belhora Fouad, Hajjaji Abdelowahed

“…This paper presents an enhanced cooling approach for Photovoltaic/Thermal (PV/T) systems aimed at improving the thermal management and overall efficiency of photovoltaic cells. The comparative study investigates two novel copper tubing designs: symmetric and asymmetric serpentine configurations. …”
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In Vitro Analyses Reveal the Effect of Synthetic Cytokinin Forchlorfenuron (FCF) on a Septin-Like Protein of Taeniid Cysticerci by Diana G. Rios-Valencia, Edgar O. López-Villegas, Dylan Diaz Chiguer, Adrian Marquez Navarro, Ruben D. Díaz-Martín, Benjamin Nogueda-Torres, Javier R. Ambrosio

“…In addition, we observed by ultrastructural observation that FCF alters the cellular subunit of the protonephridial system of cestodes, where disruption of the axoneme pattern of flame cells was observed. The rabbit polyclonal antibody prepared against the synthetic peptide recognized a major band of 41 kDa in both parasites. …”
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Repeated sevoflurane exposure causes hypomyelination in the prefrontal cortex of adult male mice by Linyong Zhang, Zhidan Ke, Ning Zhang, Dechuan Wang, Liang Zhou

“…Furthermore, disrupted proliferation of oligodendrocyte precursor cells (OPCs) contributes to repeated sevoflurane exposure-induced myelin defect. …”
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Identification of critical endoplasmic reticulum stress-related genes in advanced atherosclerotic plaque by Ning Zhao, Dan Liu, Haixu Song, Xiaolin Zhang, Chenghui Yan, Yaling Han

“…These three ERSRGs exhibited associations with various immune cells. Additionally, the three ERSRGs were upregulated in human atherosclerotic tissues, mouse models of progressive atherosclerotic lesions, and in vitro macrophage models. …”
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Advances in the treatment of glioma-related signaling pathways and mechanisms by metformin by Xingyuan Ma, Xingyuan Ma, Chao Sun, Xiao Ding, Yuhang Zhang, Yuhang Zhang, Tingzhen Deng, Tingzhen Deng, Yatao Wang, Yatao Wang, Haijun Yang, Haijun Yang, Ruiwen Ding, Ruiwen Ding, Haotian Li, Haotian Li, Dawen Wang, Dawen Wang, Maohua Zheng, Maohua Zheng

“…Additionally, metformin affects glioma stem cells by inhibiting key pathways, including STAT3, mTOR, and AKT, and altering the tumor microenvironment. …”
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Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

“…Previous research indicates that dKRAS-PDAC cells are sensitive to decitabine (DEC), an FDA-approved drug for hematological cancers, though its use in solid tumors is limited by side effects. …”
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Prominent Naturally Derived Oxidative-Stress-Targeting Drugs and Their Applications in Cancer Treatment by Eunsun Lee, Dongki Yang, Jeong Hee Hong

“…Reactive oxygen species (ROS) are involved in various pathophysiological processes and play crucial roles in DNA damage and angiogenesis. Although cancer cells have developed various adaptive defense mechanisms against oxidative stress, excessive ROS production has been proposed as an anti-cancer strategy to induce cellular apoptosis. …”
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Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model by Claudio Laurido, Alejandro Hernández, Teresa Pelissier, Luis Constandil

“…L-serine-O-sulfate (LSOS) and L-erythro-3-hydroxyaspartate (LEHA), among others, have proven to be effective in reducing the D-serine levels in culture cells. It is tempting then to try these compounds in their effectiveness to decrease nociceptive levels in rat arthritic pain. …”
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The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding by Simon Malte Lauer, Jakob Gasse, Andor Krizsan, Maren Reepmeyer, Thiemo Sprink, Rainer Nikolay, Christian M. T. Spahn, Ralf Hoffmann

“…Separation of cellular extracts derived from cells exposed to Api137 in a sucrose gradient reveals elevated levels of partially assembled and not fully matured precursors of the 50S subunit (pre-50S). …”
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Assessment of Functionals for First-Principle Studies of the Structural and Electronic Properties of δ-Bi2O3 by D. H. Galván, R. Núñez-González, R. Rangel, P. Alemany, A. Posada-Amarillas

“…Fully relativistic full-potential density functional calculations with an all-electron linearized augmented plane waves plus local orbitals method were carried out to perform a comparative study on the structural and electronic properties of the cubic oxide δ-Bi2O3 phase, which is considered as one of the most promising materials in a variety of applications including fuel cells, sensors, and catalysts. Three different density functionals were used in our calculations, LDA, the GGA scheme in the parametrization of Perdew, Burke, and Ernzerhof (PBE96), and the hybrid scheme of Perdew-Wang B3PW91. …”
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The association of gut microbiota, immunocyte dynamics, and protein–protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis by Hanxin Wu, Weijie Ma, Liangyu Zhu, Li Peng, Xun Huang, Lei Zhong, Rui Yang, Bingxue Li, Weijiang Ma, Li Gao, Xinya Wu, Jieqin Song, Suyi Luo, Fukai Bao, Aihua Liu

“…An7 indirectly affected tuberculosis through immunocyte (CD4 on CM CD4+), with a masking effect ratio of 0.008, demonstrating immune cells’ mediating role in the association between gut microbiota and tuberculosis. …”
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DS2 designer pre-fusion F vaccine induces strong and protective antibody response against RSV infection by Yiling Yang, Ruoke Wang, Fenglin Guo, Tian Zhao, Yuqing Lei, Qianqian Yang, Yige Zeng, Ziqing Yang, Tatchapon Ajavavarakula, Ruijie Tan, Mingxi Li, Haodi Dong, Mengyue Niu, Keyan Bao, Hao Geng, Qining Lv, Qi Zhang, Xuanling Shi, Peng Liu, Jiwan Ge, Xinquan Wang, Linqi Zhang

“…Monoclonal antibodies (mAbs) isolated from long-lived antibody-secreting cells (ASCs) in the bone marrow six months post-immunization with AdC68-DS2 predominantly targeted site Ø as well as site II. …”
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