Preparation and In Vivo Expression of CS-PEI/pCGRP Complex for Promoting Fracture Healing by Chun-Liang Li, Feng Qin, Rong-rong Li, Jia Zhuan, Hai-Yong Zhu, Yu Wang, Kai Wang

“…CS-PEI/pCGRP could obviously increase CGRP expression in rat bone marrow stromal cells. In vivo fracture healing experiments demonstrated that CGRP could be delivered to the body via the CS-PEI and expressed in situ after a 3-week treatment. …”
Get full text

Evaluation of the Management of Patients with Detectable Viral Load after the Implementation of Routine Viral Load Monitoring in an Urban HIV Clinic in Uganda by Nsumba Steven Mark, Musomba Rachel, Arvind Kaimal, Mubiru Frank, Tibakabikoba Harriet, Lwanga Isaac, Mohammed Lamorde, Castelnuovo Barbara

“…Of the 100 (10.1%) clinical files sampled, 61% were female, median age was 39 years (IQR: 32–47), 81% were on 1st-line ART, 19% on 2nd-line, median CD4 count was 249 cells/µL (IQR: 145–390), median log10 VL 4.42 (IQR: 3.98–4.92). …”
Get full text

Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…Expression of the NtROS1 gene in cultured human cells resulted in a global decrease in the level of genomic DNA methylation. …”
Get full text

Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway by Dong T, Li J, Liang X, Wang W, Chen M, Yang G, Wu D

“…Molecular docking was performed to identify candidate drugs. After H9c2 cells were treated with DOX and CBD, their viability, oxidative stress, and apoptosis were assessed. …”
Get full text

Lentinan's effect on gut microbiota and inflammatory cytokines in 5-FU-induced mucositis mice by Xiaoxiao Zhang, Liang Wang, Asif Iqbal Khan, Ata Ur Rehman, Kavish Hasnain Khinsar, Yi Xin

“…Furthermore, increased expression of tight junction proteins (ZO-1, Claudin-1), mucin-2, and an increase in the number of goblet cells all confirmed our previous findings. Notably, the makeup of beneficial bacteria in the stomach increased as well. …”
Get full text

Cinnamic Acid Compounds (<i>p</i>-Coumaric, Ferulic, and <i>p</i>-Methoxycinnamic Acid) as Effective Antibacterial Agents Against Colistin-Resistant <i>Acinetobacter baumannii</i> by Alaaddin Korkut, Serap Özkaya Gül, Esra Aydemir, Hakan Er, Elif Odabaş Köse

“…According to the WST assay, the compounds did not show any statistically significant cytotoxic effect on the cells (<i>p</i> > 0.05). These findings indicate that <i>p</i>-CA, FA, and <i>p</i>-MCA may be potential new alternative candidates against resistant <i>A. baumannii</i>.…”
Get full text

Evaluating ovarian follicles and their steroid hormone gene expression patterns in a high egg-producing research turkey line by George B. Hall, Diane Hildenberger, Julie A. Long, Kristen Diehl

“…At the same time, the decrease in estradiol receptor might limit the negative effects of estradiol on granulosa cells and allow for more rapid growth, suggesting a possible mechanism for the higher egg production trait of the E line.…”
Get full text

Biocementation Influence on Flexural Strength and Chloride Ingress by Lysinibacillus sphaericus and Bacillus megaterium in Mortar Structures by Daniel Karanja Mutitu, Jackson Muthengia Wachira, Romano Mwirichia, Joseph Karanja Thiong’o, Onesmus Mulwa Munyao, Muriithi Genson

“…Microbial solutions with a concentration of 1.0 × 107 cells/ml were mixed with ordinary Portland cement (OPC 42.5 N) to make mortar prisms at a water/cement ratio of 0.5. …”
Get full text

Long-term trends in the burden of multiple myeloma in China: a Joinpoint regression and age-period-cohort analysis based on GBD 2021 by Yanyu Zhang, Quanxin Su, Jiawen Yu, Xiuli Sun

“…PurposeMultiple myeloma (MM) is a hematologic malignancy originating from plasma cells with clinical manifestations such as hypercalcemia, cytopenias (most commonly anemia) and renal failure. …”
Get full text

Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets by Xuedan Lai, Ling Wu, Peihong Lin, Lijiao You, Jianwen Ye

“…Validation was performed using experimental data from Ishikawa cells treated with six candidate drugs. Among the 15 differentially expressed miRNAs, 12 were up-regulated and 3 were down-regulated in PCOS. …”
Get full text

Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…Moreover, comet assay revealed significant (p < 0.05) DNA damage in the isolated cells of kidneys, heart and brain at higher doses (80 μg/L and 120 μg/L) of thiram that was further confirmed by histo-pathological alterations in these tissues. …”
Get full text

Harvesting Baltic Microalgae <i>Chlorella vulgaris</i> BA-167 Using Coagulant Flokor 1.2A via Static Sedimentation Under Auto- and Targeted Flocculation by Małgorzata Płaczek, Agnieszka Błasiak, Stanisław Witczak

“…Flokor 1.2A facilitates the coagulation and agglomeration of microalgae cells, promoting the formation of larger aggregates (flocs) ranging from 20 μm to 690 μm, which settle more easily during gravity-driven sedimentation. …”
Get full text

Central Obesity and Associated Factors among Adult Patients on Antiretroviral Therapy (ART) in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia by Adnan Kemal, Mohammed Ahmed, Melese Sinaga Teshome, Kalkidan Hassen Abate

“…Besides, the odds of central obesity were associated with being female (AOR: 85.6; 95% CI: 20.09, 364.6), among merchants (AOR: 18.8; 95% CI: 1.39, 255.7), CD4 count <200 cells/mm3 (AOR: 0.03; 95% CI: 0.007, 0.160), among respondents taking AZT + 3TC + EFV-based ART regimen (AOR: 8.73; 95% CI: 1.33, 57.17), ABC + 3TC + ATV/r-based regimen (AOR: 0.18; 95% CI: 0.03, 0.94), increased BMI (AOR: 3.50; 95% CI: 1.36, 3.89), and abnormal blood pressure (AOR: 2.53; 95%: 1.13, 5.67). …”
Get full text

The impact of precompetition state on athletic performance among track and field athletes using machine learning by Yuting Zhang, Pengyu Fu, Qi Yu, Qingmei Niu, Dongfeng Nie, Xiangya Dou, Xiaoqin Zhang

“…The detection rate of positive urinary occult blood in the BnP group was higher than that in the BP group (P &lt; 0.05). (3) No significant differences were found in the daily dietary intake, energy consumption values, physical activity, sleep efficiency, real-time heart rate, real-time respiratory rate, and real-time heart rate variability between the intensive and reduced periods. (4) The Rosenberg Self-Esteem Scale score of the BnP group was significantly higher than that of the BP group (P &lt; 0.05).ConclusionPrecompetition absolute basophil, LDH, TG, white blood cells, creatine kinase, fat mass in the left upper limb, erythrocyte pressure (HCT), and individual failure anxiety can be used as training monitoring indicators that focus on tracking athlete status before the race.…”
Get full text

Valorisation et sauvegarde de l’identité socio-culturelle fang de Guinée Équatoriale et du Gabon dans les romans Herencia de Binendee et le pacte d’Afia by Hope ODIGUI NTOUTOUME & Hubert EDZODZOMO ONDO

“…Le roman du Gabonais, Maurice Okoumba-Nkoghe, Le pacte d’Afia (2009/2022) jette les bases du féminisme africain tandis que Herencia de Bindendee (2016) de la Guinéo-équatorienne, Trifonia Melibea Obono interroge les mentalités africaines patriarcales en général et celles guinéo-équatoriennes en particulier. À partir d’une approche féministe et sémiologique, la présente étude interroge les mécanismes romanesques des auteurs par lesquels se déploie le fang dans les romans étudiés comme en témoigne, leur titrologie.  …”
Get full text

Verification of the Reliability of an Automated Urine Test Strip Colorimetric Program Using Colorimetric Analysis: Survey Study by Keigo Inagaki, Daisuke Tsuriya, Takuya Hashimoto, Katsumasa Nakamura

“…ResultsCompared with the judgments of an automatic urine analyzer, the average agreement rate for 12 items (protein, glucose, urobilinogen, bilirubin, ketone bodies, specific gravity, occult blood, pH, white blood cells, nitrite, creatinine, and albumin) was 78.6%. …”
Get full text

The MIR181A2HG/miR‐5680/VCAN‐CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization by Weijie Zang, Yongpu Yang, Junjie Chen, Qinsheng Mao, Wanjiang Xue, Yilin Hu

“…On the other hand, VCAN binds to CD44 receptors on the surface of GC cells through autocrine secretion, activating the Hippo pathway and upregulating SP1, thereby promoting the transcription of MIR181A2HG and establishing a feedback loop driving lymphatic metastasis. …”
Get full text

EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury by Shuangfei Ni, Bo Yang, Lei Xia, Huafeng Zhang

“…We used lipopolysaccharide (LPS) to induce inflammation of microglia, and we constructed the ASCI animal model. qRT-PCR detected the relative expression levels of EZH2, HIF-1α, miR-146a-5p, IL-6, TNF-α, IL-17, PKM2, GLUT1, and HK2 in cells and tissues. Western blot was performed to detect the expression levels of EZH2, HIF-1α, H3K27me3, IL-6, TNF-α, IL-17, PKM2, GLUT1, and HK2. …”
Get full text

Relationship between biometric characteristics with semen quality of buffalos (Bubalus bubalis) by Juanita Velásquez, Juan E. Duque, Juan D. Montoya, Alexandra Usuga

“…Regarding seminal quality, means for VOL of 2.3 ± 1.1 ml, CON of 1470.7 ± 33.4 x 106 cells/ml, sperm vitality of 77.9 ± 10%, AM of 20.8 ± 12.5%, total motility of 88.9 ± 6.4% and progressive motility of 73.7 ± 10.4%, were found. …”
Get full text

Potential transmission test of GP25 vaccine in normal flora bacteria of common carp culture media by Sri Nuryati, , Alimuddin, Ayu Dhita Juliadiningtyas

“…Research was performed by adding vaccine GP25 to ampicillin-sensitive bacteria at a dose of 12.5 µg/100 µL and incubated at 28 °C for 30, 60, 180, and 300 minutes then plated on media containing ampicillin. The grown bacteria cells were tested for the existence of plasmid bearing gen GP25 through bacteria colony cracking. …”
Get full text