A Systemic Network Triggered by Human Cytomegalovirus Entry by Anyou Wang, Li Ren, Hong Li

“…Here, by employing systems biology approaches, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic pathogen. …”
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Multi-resource constrained elective surgical scheduling with Nash equilibrium toward smart hospitals by Jun Xue, Zhi Li, Shuangli Zhang

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Oncogene-tumor suppressor gene feedback interactions and their control by Baltazar D. Aguda, Ricardo C.H. del Rosario, Michael W.Y. Chan

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The nonlinear cysteine redox dynamics in the i-space: A proteoform-centric theory of redox regulation by James N. Cobley, Panagiotis N. Chatzinikolaou, Cameron A. Schmidt

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Validity of patient-derived xenograft mouse models for lung cancer based on exome sequencing data by Jaewon Kim, Hwanseok Rhee, Jhingook Kim, Sanghyuk Lee

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Physiology-informed regularisation enables training of universal differential equation systems for biological applications. by Max de Rooij, Balázs Erdős, Natal A W van Riel, Shauna D O'Donovan

“…Systems biology tackles the challenge of understanding the high complexity in the internal regulation of homeostasis in the human body through mathematical modelling. …”
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Knockdown of Annexin A1 induces apoptosis, causing G2/M arrest and facilitating phagocytosis activity in human leukemia cell lines by Hasan Masyitah, Kumolosasi Endang, Jantan Ibrahim, Jasamai Malina, Nazarudin Norlaili

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Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation by Chia-Chou Wu, Che Lin, Bor-Sen Chen

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Primary Neuronal Culture and Transient Transfection by Shun- Tseng, Peng- Chen, Eric Hwang

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SEC-MX: an approach to systematically study the interplay between protein assembly states and phosphorylation by Ella Doron-Mandel, Benjamin J. Bokor, Yanzhe Ma, Lena A. Street, Lauren C. Tang, Ahmed A. Abdou, Neel H. Shah, George Rosenberger, Marko Jovanovic

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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

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miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape by Fang Chen, Dandan Zhao, Yongfang Xu, Yi Zhang, Min-Hsuan Chen, Khyatiben V. Pathak, Nate Hansen, Brooke Lovell, Yong Liang, Katrina Estrella, Wei-Le Wang, Lucy Ghoda, Russell Rockne, Xiwei Wu, Haris Ali, Jianhua Yu, Michael A. Caligiuri, Stephen J. Forman, Jeff M. Trent, Ya-Huei Kuo, Ling Li, Piotr Swiderski, Jianying Zhang, Marcin Kortylewski, Le Xuan Truong Nguyen, Patrick Pirrotte, Mark Boldin, Guido Marcucci, Bin Zhang

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Author Correction: A sedimentary ancient DNA perspective on human and carnivore persistence through the Late Pleistocene in El Mirón Cave, Spain by Pere Gelabert, Victoria Oberreiter, Lawrence Guy Straus, Manuel Ramón González Morales, Susanna Sawyer, Ana B. Marín-Arroyo, Jeanne Marie Geiling, Florian Exler, Florian Brueck, Stefan Franz, Fernanda Tenorio Cano, Sophie Szedlacsek, Evelyn Zelger, Michelle Hämmerle, Brina Zagorc, Alejandro Llanos-Lizcano, Olivia Cheronet, José-Miguel Tejero, Thomas Rattei, Stephan M. Kraemer, Ron Pinhasi

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Drug delivery strategies to improve the treatment of corneal disorders by Mahsa Fallah Tafti, Zeinab Fayyaz, Hossein Aghamollaei, Khosrow Jadidi, Shahab Faghihi

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Increased PPARD Expression May Play a Protective Role in Human Lung Adenocarcinoma and Squamous Cell Carcinoma by Yong Zhu, Yedong Mi, Zhonghua Qin, Xuewei Jiang, Yibo Shan, Kamil Kural, Guiping Yu

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Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations by Stephanie E. King, Nicola A. Schatz, Olena Babenko, Yaroslav Ilnytskyy, Igor Kovalchuk, Gerlinde A. S. Metz

“…Here, we show in rats that PNMS has consequences for placental function and fetal brain development across four generations (F0-F3). Using a systems biology approach, comprehensive DNA methylation (DNAm), miRNA, and mRNA profiling revealed a moderate impact of PNMS in the F1 generation, but drastic changes in F2 and F3 generations, suggesting compounding effects of PNMS with each successive generation. …”
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A design principle for neuronal firing with up-down oscillation through Na+ dynamics by Tomohide R. Sato, Koji L. Ode, Fukuaki L. Kinoshita, Hiroki R. Ueda

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Cultural Science Meets Cultural Data Analytics by Ibrus Indrek, Schich Maximilian, Tamm Marek

“…We instead argue for a study of meaning-making practices in human society, but without confining ourselves to traditional humanities scholarship, but rather, learning from new developments in systems biology, evolutionary economics, complexity science and many more. …”
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СИСТЕМНАЯ БИОЛОГИЯ

“…Об активном развитии этой области биологии в последнее время говорит следующий факт: количество статей, представленных PubMed и содержащих фразу «systems biology», увеличилось со 140 в 2003 г. до более 10 000 в 2013 г.…”
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Identifiability of mathematical models in medical biology by S. I. Kabanikhin, D. A. Voronov, A. A. Grodz, O. I. Krivorotko

“…Analysis of biological data is a key topic in bioinformatics, computational genomics, molecular modeling and systems biology. The methods covered in this article could reduce the cost of experiments for biological data. …”
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