Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations by Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui

“…Moreover, through a systematic analysis, MD simulations and MM-GBSA binding free energy calculations revealed that the best candidates Ergotamine, S55746, NPC478048, Lifirafenib, and NPC77101 are highly stable drug candidates in complex with TMPRSS4, displaying low RMSD and RMSF values with strong binding stability. …”
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Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice by Jin Qiu, Yuhan Guo, Xiaozhen Guo, Ziqi Liu, Zixuan Li, Jun Zhang, Yutang Cao, Jiaqi Li, Shuwu Yu, Sainan Xu, Juntong Chen, Dongmei Wang, Jian Yu, Mingwei Guo, Wenhao Zhou, Sainan Wang, Yiwen Wang, Xinran Ma, Cen Xie, Lingyan Xu

“…Abstract Muscular atrophy is among the systematic decline in organ functions in aging, while defective thermogenic fat functionality precedes these anomalies. …”
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Health-Related Quality of Life in Gilles de la Tourette Syndrome: A Decade of Research by Andrea Eugenio Cavanna, Kate David, Valentina Bandera, Cristiano Termine, Umberto Balottin, Anette Schrag, Caroline Selai

“…We set out to answer the question "Is HR-QOL affected by GTS and, if so, in what domains?" by conducting a systematic literature review of published original studies addressing HR-QOL in both children and adult patients with GTS. …”
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Malocclusion and Its Relationship with Sound Speech Disorders in Deciduous and Mixed Dentition: A Scoping Review by Mariangela Aprile, Alessio Verdecchia, Claudia Dettori, Enrico Spinas

“…<b>Methods:</b> The present scoping review has been conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. …”
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Mucosal immune response in biology, disease prevention and treatment by Xiaoxue Zhou, Yuchen Wu, Zhipeng Zhu, Chu Lu, Chunwu Zhang, Linghui Zeng, Feng Xie, Long Zhang, Fangfang Zhou

“…The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has underscored the critical role of mucosal immunity in disease prevention and treatment. This systematic review focuses on the dynamic interactions between mucosa-associated lymphoid structures and related diseases. …”
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Scope of work and contributions of female community health volunteers in Nepal’s healthcare sector: a qualitative study by Archana Shrestha, Biraj Man Karmacharya, Surakshya Kunwar, Sudim Sharma, Sabina Marasini, Anjali Joshi, Bandana Paneru, Akina Shrestha

“…In addition, they indicated that the FCHVs could possibly alleviate the shortage of health workforce by providing preventive and promotive healthcare services at the grassroot level.Conclusion Our study showed a need for systematic and integrated health programme delivery packages thereby reducing additional workload and burden among FCHVs.…”
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Enhanced bulk and interfacial charge transfer in Fe:VOPO4 modified Mo:BiVO4 photoanodes for photoelectrochemical water splitting by Bing He, Yu Cao, Kaijie Lin, Mingjie Wu, Yunhai Zhu, Xun Cui, Liang Hu, Yingkui Yang, Xueqin Liu

“…Consequently, the resultant Fe:VOPO4/Mo:BVO4 photoanode exhibits a remarkable photocurrent density of 6.59 ​mA ​cm−2 ​at 1.23 ​V versus the reversible hydrogen electrode (VRHE) under AM 1.5G illumination, over approximately 5.5 times as high as that of pristine BiVO4. Systematic studies have demonstrated that the hopping activation energy of small polarons is significantly reduced due to the Mo doping, resulting in accelerated bulk charge transfer. …”
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Identifying a probe to visualize the variability of operating teams for supporting the human reliability analysis of nuclear power plants: An explanatory study by Jinkyun Park, Wasin Vechgama, Seung Ki Shin

“…., crew-to-crew variability), it is crucial to figure out how to visualize this variability in a systematic way. In this regard, comparing the cultural characteristics of operating teams with their performance would be a good starting point. …”
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A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism by Erica L. Underwood, Lucien T. Thompson

“…While high-fat diets are associated with rising incidence of obesity/type-2 diabetes and can induce metabolic and cognitive deficits, sex-dependent comparisons are rarely systematically made. Effects of exclusive consumption of a high-fat diet (HFD) on systemic metabolism and on behavioral measures of hippocampal-dependent memory were compared in young male and female LE rats. …”
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Microscopic Traffic Simulation Calibration Level for Reliable Estimation of Vehicle Emissions by Jinsoo Kim, Jae Hun Kim, Gunwoo Lee, Hyun-ju Shin, Jahng Hyon Park

“…Accordingly, we propose a systematic guideline for calibration to ensure reliable micro-scale emissions estimates. …”
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Numerical Well Testing Interpretation Model and Applications in Crossflow Double-Layer Reservoirs by Polymer Flooding by Haiyang Yu, Hui Guo, Youwei He, Hainan Xu, Lei Li, Tiantian Zhang, Bo Xian, Song Du, Shiqing Cheng

“…Our research shows that the type curves have five segments with different flow status: (I) wellbore storage section, (II) intermediate flow section (transient section), (III) mid-radial flow section, (IV) crossflow section (from low permeability layer to high permeability layer), and (V) systematic radial flow section. The polymer flooding field tests prove that our model can accurately determine formation parameters in crossflow double-layer reservoirs by polymer flooding. …”
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Graded transcendental functions: an application to four-point amplitudes with one off-shell leg by Thomas Gehrmann, Johannes Henn, Petr Jakubčík, Jungwon Lim, Cesare Carlo Mella, Nikolaos Syrrakos, Lorenzo Tancredi, William J. Torres Bobadilla

“…Abstract Several recent works have demonstrated the powerful algebraic simplifications that can be achieved for scattering amplitudes through a systematic grading of transcendental quantities. We develop these concepts to construct a minimal basis of functions tailored to a scattering amplitude in a general way. …”
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Exploring Vocational Evaluation Practices following Traumatic Brain Injury by Christina Dillahunt-Aspillaga, Tammy Jorgensen Smith, Ardis Hanson, Sarah Ehlke, Mary Stergiou-Kita, Charlotte G. Dixon, Davina Quichocho

“…Vocational evaluation (VE) is a systematic process that involves assessment and appraisal of an individual’s current work-related characteristics and abilities. …”
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Effect of segregation on hot deformation behavior of GCr15 bearing steel in continuous casting by Mingyang Liu, Tianyu Zhang, Chenchong Wang, Ye Liu, Junyang Qian, Hongshuang Di, Qing Yin, Chi Zhang

“…In this study, a comprehensive investigation was conducted to systematically assess the hot deformation behavior of continuously cast GCr15 steel under varying degrees of macro- and micro-segregation through hot compression testing. …”
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Modeling the Differences in Biochemical Capabilities of Pseudomonas Species by Flux Balance Analysis: How Good Are Genome-Scale Metabolic Networks at Predicting the Differences? by Parizad Babaei, Tahereh Ghasemi-Kahrizsangi, Sayed-Amir Marashi

“…Such models have provided us with a framework for systematic analysis of metabolism. However, little effort has been put towards comparing biochemical capabilities of closely related species using their metabolic models. …”
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Exploration of policy feedback mechanism for healthcare improvement in China: a grounded theory model by Tuo-Dong Zhu, Ming-Jin Yang, Hao Wu, Hao Wu

“…BackgroundDespite increasing governments’ endeavors to improve the quality of medical services focused on patient experience, it has been difficult due to a lack of systematic and replicable theories to guide healthcare improvement. …”
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<i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects by Víctor de C. Martins, Maria Alice E. da Silva, Valdir F. da Veiga, Henrique M. G. Pereira, Claudia M. de Rezende

“…The aim of this review is to update the chemical diversity of <i>ent</i>-kaurane diterpenoids in green and roasted coffee, detailing each new compound and reporting its biological potential. A systematic review was performed using the bibliographic databases (SciFinder, Web of Science, ScienceDirect) and specific keywords such as “coffea diterpenes”, “coffee diterpenes”, “coffee ent-kaurane diterpenes” and “coffee diterpenoids”. …”
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Knowledge and Attitude on Obstetric Effects of Female Genital Mutilation among Maasai Women in Maternity Ward at Loitokitok Sub-County Hospital, Kenya by Keddy Wanjiru Muchene, Irene Gacheri Mageto, Joyce Jebet Cheptum

“…A hospital-based cross-sectional study was conducted at Loitokitok Sub-County Hospital among 64 Maasai women who had undergone FGM. Systematic sampling was employed to identify the respondents. …”
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Sustainable employability in Supported Employment and IPS interventions in the context of the characteristics of work and perspectives of the employers: a scoping review protocol by Pirjo Juvonen-Posti, Matti Joensuu, Joonas Poutanen, Kirsi Unkila

“…The objective of the proposed scoping review is to systematically explore what is known about sustainable employability in SE and IPS interventions in the context of the characteristics of work and perspectives of the employers.Methods and analyses The scoping review methodological framework by Arksey and O’Malley and its recently enhanced versions are used as guidelines in this study. …”
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A Survey on True Random Number Generators Based on Chaos by Fei Yu, Lixiang Li, Qiang Tang, Shuo Cai, Yun Song, Quan Xu

“…This survey paper intends to provide a systematic review of true random number generators (TRNGs) based on chaos. …”
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