DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer by Jiayu Zhang, Yingxi Zhao, Ruijuan Liang, Xue Zhou, Zhonghua Wang, Cheng Yang, Lingyue Gao, Yonghao Zheng, Hui Shao, Yang Su, Wei Cui, Lina Jia, Jingyu Yang, Chunfu Wu, Lihui Wang

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Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells by Yunjie Wang, Xiaohui Sun, Runchen Ma, Xiaofan Zhang, Shengmin Ji, Zhaofeng Liu, Gangqiang Yang, Hongbo Wang, Peng Zhang, Jianzhao Zhang, Jingwei Tian

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Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies by Raashi Chauhan, Rama Rao Damerla, Vijay Shree Dhyani

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Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS‐mutant cancer by Zhang Yang, Shun‐Qing Liang, Maria Saliakoura, Haitang Yang, Eric Vassella, Georgia Konstantinidou, Mario Tschan, Balazs Hegedüs, Liang Zhao, Yanyun Gao, Duo Xu, Haibin Deng, Thomas M Marti, Gregor J Kocher, Wenxiang Wang, Ralph A Schmid, Ren‐Wang Peng

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RET Inhibitor SPP86 Is a Potential Candidate for the Clinical Treatment of Cutaneous Melanoma [Letter] by Tan Y, Li R

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LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma by Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli

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MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? by Tingting Zhang, Ningning Li, Chaoyang Sun, Yang Jin, Xia Sheng

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Toward an integrated map of genetic interactions in cancer cells by Benedikt Rauscher, Florian Heigwer, Luisa Henkel, Thomas Hielscher, Oksana Voloshanenko, Michael Boutros

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Application and research progress of synthetic lethality in the development of anticancer therapeutic drugs by Xiaoliang Gong, Chunxi Liu, Haoyang Tang, Song Wu, Qingyun Yang

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TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers by Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik W. Wilker, Samuel R. Meier, Yi Yu, Teng Teng, Alan Huang, John P. Maxwell

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Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors by Megan Stevens, Yuanli Wang, Stephanie J. Bouley, Torrey R. Mandigo, Aditi Sharma, Sonali Sengupta, Amy Housden, Norbert Perrimon, James A. Walker, Benjamin E. Housden

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Ivabradine induces RAD51 degradation, potentiating PARP inhibitor efficacy in non-germline BRCA pathogenic variant triple-negative breast cancer by Ho Tsoi, George Man Hong Leung, Ellen Pui Sum Man, Chan Ping You, Koei Ho Lam Cheung, Kelvin Yuen Kwong Chan, Chun Gong, Michael Shing Yan Huen, Ui Soon Khoo

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PARP inhibitors in melanoma treatment: potential, challenges, and future directions by Angela Anaeme, Karen Moussa, Abdallah N. Mansour, George Nassief, George Ansstas

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Multi‐modal meta‐analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor by Alok Jaiswal, Prson Gautam, Elina A Pietilä, Sanna Timonen, Nora Nordström, Yevhen Akimov, Nina Sipari, Ziaurrehman Tanoli, Thomas Fleischer, Kaisa Lehti, Krister Wennerberg, Tero Aittokallio

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Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer by Anjan Venkatesh, Niall Quinn, Swathi Ramachandra Upadhya, Barbara De Kegel, Alfonso Bolado Carrancio, Thomas Lefeivre, Olivier Dennler, Kieran Wynne, Alexander von Kriegsheim, Colm J Ryan

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Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer by Ewelina Szymańska, Paulina Nowak, Krzysztof Kolmus, Magdalena Cybulska, Krzysztof Goryca, Edyta Derezińska‐Wołek, Anna Szumera‐Ciećkiewicz, Marta Brewińska‐Olchowik, Aleksandra Grochowska, Katarzyna Piwocka, Monika Prochorec‐Sobieszek, Michał Mikula, Marta Miączyńska

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An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies by Jing Wang, Yuqi Wen, Yixin Zhang, Zhongming Wang, Yuyang Jiang, Chong Dai, Lianlian Wu, Dongjin Leng, Song He, Xiaochen Bo

Subjects: “…Synthetic lethality…”
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Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma by Benjamin Lin, Abigail K. Shelton, Erin Smithberger, Julia Ziebro, Kasey R. Skinner, Ryan E. Bash, Richard Kirkman, Allie Stamper, Madison Butler, Alex Flores, Steven P. Angus, Michael P. East, Timothy F. Cloughesy, David A. Nathanson, Michael E. Berens, Jann N. Sarkaria, Zev A. Binder, Donald M. O’Rourke, Timothy C. Howton, Brittany N. Lasseigne, Christopher D. Willey, Gary L. Johnson, Anita B. Hjelmeland, Frank B. Furnari, C. Ryan Miller

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Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage by Anell Fernandez, Maider Artola, Sergio Leon, Nerea Otegui, Aroa Jimeno, Diego Serrano, Alfonso Calvo

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Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels by Katharina Imkeller, Giulia Ambrosi, Nancy Klemm, Ainara Claveras Cabezudo, Luisa Henkel, Wolfgang Huber, Michael Boutros

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