Multi-gene precision editing tool using CRISPR-Cas12a/Cpf1 system in Ogataea polymorpha by Senqin Hou, Shibin Yang, Wenqin Bai

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Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

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Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species by Zepeng Qu, Hongbin Liu, Ji Yang, Linggang Zheng, Jumin Huang, Ziming Wang, Chun Xie, Wenlong Zuo, Xiong Xia, Lin Sun, Yifa Zhou, Ying Xie, Jingguang Lu, Yizhun Zhu, Lili Yu, Lihua Liu, Hua Zhou, Lei Dai, Elaine Lai-Han Leung

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A design principle for neuronal firing with up-down oscillation through Na+ dynamics by Tomohide R. Sato, Koji L. Ode, Fukuaki L. Kinoshita, Hiroki R. Ueda

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Development of robust constitutive synthetic promoter using genetic resources of plant pararetroviruses by Tsheten Sherpa, Tsheten Sherpa, Nrisingha Dey

“…With the advancement of plant synthetic biology, complex genetic engineering circuits are being developed, which require more diverse genetic regulatory elements (promoters) to operate. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

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Hydrophobic deep eutectic solvents as novel, sustainable aids for intracellular protein release from Saccharomyces cerevisiae by Tjalling Gijsbert Tjalsma, Yannick Patrice Didion, Ziran Su, Magdalena Malankowska, Pablo Torres-Montero, José Luis Martínez, Manuel Pinelo

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Fc-binding nanodisc restores antiviral efficacy of antibodies with reduced neutralizing effects against evolving SARS-CoV-2 variants by Jaehyeon Hwang, Soyun Choi, Beom Kyu Kim, Sumin Son, Jeong Hyeon Yoon, Kyung Won Kim, Wonbeom Park, Hyunjoo Choo, Suhyun Kim, Soomin Kim, Seokhyeon Yu, Sangwon Jung, Sang Taek Jung, Min-Suk Song, Sang Jick Kim, Dae-Hyuk Kweon

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Application of emerging technologies for gut microbiome research by Wit Thun Kwa, Saishreyas Sundarajoo, Kai Yee Toh, Jonathan Lee

“…As the emerging technologies for microbiome research continue to evolve (i.e. metatranscriptomics, metabolomics, culturomics, synthetic biology), microbiome research has moved beyond phylogenetic descriptions and towards mechanistic analyses. …”
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Vaccination ARN messager (ARNm), modèle de transition de la biologie fondamentale à la médecine by Sansonetti, Philippe J.

“…Sixty years of doubts for some and certainties for others about the possibility of using mRNA—an example of synthetic biology—in therapeutic medicine and vaccinology. …”
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AI, big data, and robots for the evolution of biotechnology by Haseong Kim

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Éléments pour une théorie biologique du sujet by Lionel Simonneau

“…Finally, we end by an interrogation: how is any theory of the subject, especially those developed in this particular issue of this journal, getting on when it is applied not to the current man but to the so-called “enhanced human”, in a transhumanist society, where biological, physical, cognitive, emotional characteristics are hugely modified by the synthetic biology and the nanotechnologies?…”
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Birhythmicity and Hard Excitation from Coupled Synthetic Feedback Loops by Aimin Chen, Caixia Liu, Junwei Wang

“…Synthetic biology opens up the possibility of creating circuits that would not survive in the natural world and studying their behaviors in living cells, expanding our notion of biology. …”
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Optimal network sizes for most robust Turing patterns by Hazlam S. Ahmad Shaberi, Aibek Kappassov, Antonio Matas-Gil, Robert G. Endres

“…Our findings may inform future synthetic biology approaches and provide insights into bridging the gap to complex developmental pathways.…”
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Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy by Cheng-Zhi Wang, Robert A. Kazmierczak, Abraham Eisenstark

“…Furthermore, bacterial clinical treatments for cancer have been improved by combination with other therapeutic methods such as chemotherapeutic drugs and radioactive agents. Synthetic biology techniques have also driven the development of new bacterial-based cancer therapies. …”
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Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection by Ning Zhou, Jingchen Yu, Xujiao Liu, Chengxi Li, Huang Tang, Lin Lyu, Chengwei Wu, Yana Chen, Jian Zhang, Jinjing Ni, Danni Wang, Jing Tao, Wenjuan Wu, Yu Zhang, Yun Feng, Yanjie Chao, Jie Lu, Ping He, Yu-Feng Yao

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Public attitudes to genetic technology for invasive pest control and preferences for engagement and information: a segmentation analysis by Elizabeth V. Hobman, Aditi Mankad, Lucy Carter, Kerry Collins

“…The results provide insight into 1) the diversity of views, and associated beliefs and feelings, among the public when confronted with a synthetic biology solution to an environmental problem, 2) how public engagement activities can be tailored to align with people’s engagement beliefs and stated preferences, and 3) what issues biotechnology developers should address as they endeavour to design genetic technology in a socially responsible way.…”
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Introducing carbon assimilation in yeasts using photosynthetic directed endosymbiosis by Yang-le Gao, Jay Cournoyer, Bidhan C. De, Catherine L. Wallace, Alexander V. Ulanov, Michael R. La Frano, Angad P. Mehta

“…We anticipate that our studies will have significant implications for sustainable biotechnology, synthetic biology, and experimentally studying the evolutionary adaptation of an additional organelle in yeast.…”
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Engineering artificial photosynthetic life-forms through endosymbiosis by Jay Cournoyer, Sarah D. Altman, Yang-le Gao, Catherine L. Wallace, Dianwen Zhang, Guo-Hsuen Lo, Noah T. Haskin, Angad P. Mehta

“…We anticipate that these genetically tractable endosymbiotic platforms can be used for evolutionary studies, particularly related to organelle evolution, and also for synthetic biology applications.…”
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