Understanding and Prevention of “Therapy-” Induced Dyskinesias by Iciar Aviles-Olmos, Zinovia Kefalopoulou, Thomas Foltynie

“…LID results from nonphysiological dopamine release, supersensitivity of dopamine receptors, and consequent abnormal signalling through mechanisms of synaptic plasticity. Restoration of physiological circuitry within the basal ganglia loops is ultimately the aim of all cell and gene therapy approaches but each using distinctive strategies and accompanied by risks of exacerbation of LID or development of “off-phase”/GID. …”
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Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations by Huilai Tian, Eliot Davidowitz, Patricia Lopez, Sharareh Emadi, James Moe, Michael Sierks

“…Recent studies show that extracellular oligomeric tau can inhibit memory formation and synaptic function and also transmit pathology to neighboring neurons. …”
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Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics by Thomas Vaissiere, Sheldon D. Michaelson, Thomas Creson, Jessie Goins, Daniel Fürth, Diana Balazsfi, Camilo Rojas, Randall Golovin, Konstantinos Meletis, Courtney A. Miller, Daniel O’Connor, Lorenzo Fontolan, Gavin Rumbaugh

“…Disrupted neuronal dynamics were associated with circuit-specific long-range synaptic connectivity abnormalities. Our data support a model where autonomous Syngap1 expression in cortical excitatory neurons promotes cognitive abilities through the assembly of long-range circuits that integrate temporally-overlapping sensory and motor signals, a process that promotes perception and attention. …”
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Neural Compensations After Lesion of the Cerebral Cortex by Bryan Kolb, Russell Brown, Alane Witt-Lajeunesse, Robbin Gibb

“…Finally, anatomical evidence suggests that the mechanism of action of many treatments is through changes in dendritic arborization, which presumably reflects changes in synaptic organization. Factors that enhance dendritic change stimulate functional compensation, whereas factors that retard or block dendritic change block or retard compensation.…”
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Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease by Hongling Zhu, Y. Terry Lee, Colleen Byrnes, Jabili Angina, Danielle A. Springer, Galina Tuymetova, Mari Kono, Cynthia J. Tifft, Richard L. Proia

“…Tsc2 reduction also partially rescued aberrant synaptic function–related gene expression. These findings imply that enhancing mTOR signaling could be a potential therapeutic strategy for lysosomal-based neurodegenerative diseases.…”
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Drug inhibition and substrate transport mechanisms of human VMAT2 by Feiwen Wei, Huihui Liu, Wei Zhang, Jufang Wang, Yanqing Zhang

“…Abstract Vesicular monoamine transporter 2 (VMAT2) is crucial for packaging monoamine neurotransmitters into synaptic vesicles, with their dysregulation linked to schizophrenia, mood disorders, and Parkinson’s disease. …”
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Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology? by Oscar Kurt Bitzer-Quintero, Ignacio González-Burgos

“…These cells release immune mediators, such as cytokines, that modulate synaptic transmission and that alter the morphology of dendritic spines during the inflammatory process following injury. …”
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Impaired Autophagy of GABAergic Interneurons in Neuropathic Pain by Yuhua Yin, Min-Hee Yi, Dong Woon Kim

“…NP is believed to be driven by cell type-specific spinal synaptic plasticity in the dorsal horn. Upon intense afferent stimulation, spinothalamic tract neurons are potentiated, whereas GABAergic interneurons are inhibited leading to long-term depression. …”
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Functional Properties of Human Stem Cell-Derived Neurons in Health and Disease by Jason P. Weick

“…For neurons of the CNS, the ultimate phenotypic characterization lies with their ability to recapitulate functional properties such as passive and active membrane characteristics, synaptic activity, and plasticity. These features critically depend on the coordinated expression and localization of hundreds of ion channels and receptors, as well as scaffolding and signaling molecules. …”
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Ranking of Search Requests in the Digital Information Retrieval System Based on Dynamic Neural Networks by Viera Bartosova, Svetlana Drobyazko, Sergii Bogachov, Olga Afanasieva, Maria Mikhailova

“…It has been proven that the built models differ in the rules for determining the coefficients of synaptic connections and external shifts; each of the created rules can be used independently or in different combinations with one another. …”
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The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction by Dawn E. Muskiewicz, George R. Uhl, F. Scott Hall

“…Considering the well-documented evidence supporting a role for various CAMs in synaptic plasticity, axonal growth, and regeneration, it is not surprising that allelic variation in CAM genes might also play a role in addiction liability. …”
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Unsupervised Learning in a Ternary SNN Using STDP by Abhinav Gupta, Sneh Saurabh

“…Further, we show that a pair of dual-pocket Fully-Depleted Silicon-on-Insulator (FD-SOI) MOSFETs can be utilized to generate a current, which reduces exponentially with increasing duration of firing events between pre- and post-synaptic neurons. This current modulates the synapse’s conductance according to STDP. …”
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Immune Dysfunction in Tourette Syndrome by Ishraga Elamin, Mark J. Edwards, Davide Martino

“…The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. …”
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Inhibition of Glycogen Synthase Kinase and the Neuroprotective Function of Conjugated ZnO-Osthol Nanoparticles in Alzheimer’s Disease by Nahed S. Alharthi, Fahad M. Aldakheel, Abdulkarim S. Binshaya

“…Osthol treatment has also prevented synaptic proteins such as postsynaptic density-95 (PSD-95), synaptophysin (SYP), and synapsin-1 from decreasing in APP-induced BE (2)-M17 cells. …”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Astrocytes regulate neuronal homeostasis, excitability, and synaptic plasticity, playing key roles in maintaining the blood–brain barrier (BBB) and mediating neuroinflammatory responses. …”
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Associative learning and recollection of olfactory memory during the respiratory cycle in mammals: how is the self cognized in consciousness? by Kensaku Mori, Hitoshi Sakano

“…Reactivation of pyramidal cells during the exhalation phase may induce plastic changes in the inter-areal synaptic connections in the neural network to form associative-learning memory. …”
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Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex. by Shun Hao, Man Xue, Qi-Yu Chen, Jinjin Wan, Yu-Jie Ma, Wantong Shi, Xuanying Chen, Xu-Hui Li, Jing-Shan Lu, Fang Xu, Guo-Qiang Bi, Wucheng Tao, Min Zhuo

“…Although the projections from the RSC to the ACC have been found, the specifics of the synaptic connections and the functional implications of the RSC-ACC projections remain less understood. …”
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Astrocyte and Neuronal Plasticity in the Somatosensory System by Robert E. Sims, John B. Butcher, H. Rheinallt Parri, Stanislaw Glazewski

“…One form, termed coding plasticity, concerns changes in synaptic transmission and connectivity between neurons. …”
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Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory by Oliver Rawashdeh, Rex Parsons, Erik Maronde

“…Observations suggest important and largely unexplored roles of the clock gene protein PER1 in synaptic plasticity and in the daytime-dependent modulation of learning and memory. …”
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Noradrenergic Modulation of Cognition in Health and Disease by Olga Borodovitsyna, Matthew Flamini, Daniel Chandler

“…Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic transmission in the central nervous system through its actions at a number of pre- and postsynaptic receptors. …”
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