Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons by Gabriele Marcassa, Dan Dascenco, Blanca Lorente-Echeverría, Danie Daaboul, Jeroen Vandensteen, Elke Leysen, Lucas Baltussen, Andrew J. M. Howden, Joris de Wit

“…Our approach is versatile and can be broadly applied to other neuron types to create a protein-based, synaptic atlas of cortical circuits.…”
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Cortical Circuitry and Synaptic Dysfunctions in Alzheimer’s Disease and Other Dementias by Federico Ranieri, Alberto Benussi, Mariagiovanna Cantone, Florinda Ferreri, Javier Márquez-Ruiz

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The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases by Jennifer R. Kowalski, Peter Juo

“…This review is focused on highlighting our current understanding of DUBs that regulate synaptic function and the diseases that result from dysfunction of these DUBs.…”
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P-Body Components, microRNA Regulation, and Synaptic Plasticity by Jens Hillebrand, Scott A. Barbee, Mani Ramaswami

“…Namely, that P-body proteins may play important roles in regulation of dendrite-localized mRNAs and, thereby, in synaptic plasticity. A wide range of protein localization and early functional data support this hypothesis. …”
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Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience by Devin Rocks, Conor Liston

“…In this review, we examine how chronic stress and antidepressants modulate synaptic connectivity in stress-sensitive brain circuits. …”
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Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB by Christian Engelmann, Ronny Haenold

“…Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF-κB dimers move to the nucleus to translate synaptic signals into altered gene expression. …”
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Synaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X Syndrome by Tao Yang, Huan Zhao, Changbo Lu, Xiaoyu Li, Yingli Xie, Hao Fu, Hui Xu

“…But for now, most studies excessively emphasized the one-sided factor on the change of synaptic plasticity participating in the generation of anxiety during the development of FXS. …”
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Hyaluronidase-induced matrix remodeling contributes to long-term synaptic changes by Rostislav Sokolov, Rostislav Sokolov, Viktoriya Krut', Viktoriya Krut', Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Andrey Rozov, Andrey Rozov, Irina V. Mukhina, Irina V. Mukhina

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Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis by Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Ortega

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Synaptic energy drives the information processing mechanisms in spiking neural networks by Karim El Laithy, Martin Bogdan

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Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First? by Michela Zaltieri, Francesca Longhena, Marina Pizzi, Cristina Missale, PierFranco Spano, Arianna Bellucci

“…Here, we reviewed data supporting either that α-synuclein synaptic deposition precedes and indirectly triggers mitochondrial damage or that mitochondrial deficits lead to neuronal dysfunction and α-synuclein synaptic accumulation. …”
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BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex by Emily Petrus, Hey-Kyoung Lee

“…Our results indicate that BACE1 plays an essential role in sensory experience-dependent homeostatic synaptic plasticity in the neocortex.…”
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Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease by Judy Cheng, Ellen T. Koch, Daniel Ramandi, James P. Mackay, Timothy P. O’Leary, William Rees-Jones, Lynn A. Raymond

“…While degeneration of striatal D2-type dopamine receptor (D2)-expressing indirect pathway medium spiny neurons (iMSNs) occurs prior to that of D1-type dopamine receptor (D1)-expressing direct pathway neurons, altered corticostriatal synaptic function precedes degeneration. D2-mediated signaling on iMSNs reduces their excitability and promotes endocannabinoid (eCB) synthesis, suppressing glutamate release from cortical afferents. …”
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Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex by John Vargas-Ortiz, Lin Lin, Vena K. Martinez, Rong-jian Liu, Rachel Babij, Zhe Ran S. Duan, Sam Wacks, Liyuan Sun, Amanda Wang, Sajida Khan, John Lee Soto-Vargas, Natalia V. De Marco García, Alicia Che

“…Monosynaptic rabies tracing and slice electrophysiology experiments reveal that layer 2/3 pyramidal neurons receive significant layer 5 inputs during the first postnatal week, and silencing layer 5 synaptic outputs results in a significant reduction in spontaneous activity, abnormal sensory-evoked activity and disrupted layer 4-layer 2/3 connectivity. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Our results demonstrated an impairment of both induction and maintenance of long term synaptic potentiation in NPC1−/− mouse slices, associated with the lack of ERKs phosphorylation. …”
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Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex by Saïd Kourrich, Stephen D. Glasgow, Douglas A. Caruana, C. Andrew Chapman

“…The entorhinal cortex receives a large projection from the piriform cortex, and synaptic plasticity in this pathway may affect olfactory processing. …”
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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

“…This paper mainly focuses on brain calcium-independent PLA2 (iPLA2) and on the mechanisms by which they influence neuronal function and regulate synaptic plasticity. Particular attention will be given to the iPLA2γ isoform and its role in the regulation of synaptic glutamate receptors. …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…This study summarizes the pathogenesis of central sensitization from the perspective of neuroglial crosstalk and synaptic plasticity and underlines the related analgesic mechanisms of acupuncture. …”
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Blobby is a synaptic active zone assembly protein required for memory in Drosophila by J. Lützkendorf, T. Matkovic-Rachid, S. Liu, T. Götz, L. Gao, O. Turrel, M. Maglione, M. Grieger, S. Putignano, N. Ramesh, T. Ghelani, A. Neumann, N. Gimber, J. Schmoranzer, A. Stawrakakis, B. Brence, D. Baum, Kai Ludwig, M. Heine, T. Mielke, F. Liu, A. M. Walter, M. C. Wahl, S. J. Sigrist

“…Abstract At presynaptic active zones (AZs), scaffold proteins are critical for coordinating synaptic vesicle release and forming essential nanoarchitectures. …”
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Optoelectric coordinated modulation of resistive switching behavior in perovskite based synaptic device by Yucheng Wang, Ruixi Huang, Wenyi Zhang, Dingyun Guo, Jiawei Zheng, Hexin Wang, Fobao Huang, Zhuoya Wang, He Guan

“…This study holds significant implications for guiding the optoelectronic co-regulation of perovskite synaptic devices in the field of synaptic electronics.…”
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