Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss by Lijuan Shi, Ying Chang, Xiaowei Li, Steve Aiken, Lijie Liu, Jian Wang

“…Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.…”
Get full text

Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization by Nuria Domínguez-Iturza, María Calvo, Marion Benoist, José Antonio Esteban, Miguel Morales

“…Spines receive the majority of glutamatergic synaptic inputs. Their morphology, dynamics, and density have been related to synaptic plasticity and learning. …”
Get full text

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation by Mathias Guayasamin, Lewis R Depaauw-Holt, Ifeoluwa I Adedipe, Ossama Ghenissa, Juliette Vaugeois, Manon Duquenne, Benjamin Rogers, Jade Latraverse-Arquilla, Sarah Peyrard, Anthony Bosson, Ciaran Murphy-Royal

“…These behavioural changes were associated with impaired synaptic plasticity, increased neural excitability, and astrocyte hypofunction. …”
Get full text

Action inflexibility and compulsive-like behavior accompany neurobiological alterations in the anterior orbitofrontal cortex and associated striatal nuclei by Laura M. Butkovich, Sophie T. Yount, Aylet T. Allen, Esther H. Seo, Andrew M. Swanson, Shannon L. Gourley

“…They also display higher levels of the excitatory synaptic marker striatin in the nucleus accumbens and lower levels of the excitatory synaptic marker SAPAP3 in the dorsal striatum, striatal nuclei that receive input from the anterior OFC. …”
Get full text

Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage by Micol Tomaiuolo, Cynthia Katche, Haydee Viola, Jorge H. Medina

“…The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. …”
Get full text

Comparative proteomic analysis of astrocytoma tissues from patients with and without seizures by Thanakorn Khaosuwan, Kittinun Leetanaporn, Pongsakorn Choochuen, Raphatphorn Navakanitworakul, Anukoon Kaewborisutsakul, Thara Tunthanatip, Surasak Sangkhathat, Wararat Chiangjong, Kanitpong Phabphal

“…Proteins downregulated in patients with seizures included those involved in trans-synaptic signalling and gamma-aminobutyric acid synaptic transmission. …”
Get full text

In Vivo Plasticity at Hippocampal Schaffer Collateral-CA1 Synapses: Replicability of the LTP Response and Pharmacology in the Long-Evans Rat by A. Ahnaou, E. White, R. Biermans, N. V. Manyakov, W. H. I. M. Drinkenburg

“…Results: (1) When compared to Sprague-Dawley (SD) rats, the HFS using a stimulus intensity of 50% of the maximum slope obtained from input/output (I/O) curves elicited lower and higher thresholds of synaptic plasticity responses in SD and LE rats, respectively. …”
Get full text

CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex by Annabella Pignataro, Antonella Borreca, Martine Ammassari-Teule, Silvia Middei

“…Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. …”
Get full text

Molecular architecture of the altered cortical complexity in autism by Makliya Mamat, Yiyong Chen, Wenwen Shen, Lin Li

“…Partial least squares regression analysis revealed gene sets associated with these cortical complexity changes, enriched for biological functions related to synaptic transmission, synaptic plasticity, mitochondrial dysfunction, and chromatin organization. …”
Get full text

Coincidence Detection Using Spiking Neurons with Application to Face Recognition by Fadhlan Kamaruzaman, Amir Akramin Shafie, Yasir M. Mustafah

“…We elucidate the practical implementation of Spiking Neural Network (SNN) as local ensembles of classifiers. Synaptic time constant τs is used as learning parameter in representing the variations learned from a set of training data at classifier level. …”
Get full text

Chronic Fluoxetine Treatment Suppresses Plasticity (Long-Term Potentiation) in the Mature Rodent Primary Auditory Cortex In Vivo by Hans C. Dringenberg, Leora R. Branfield Day, Deanna H. Choi

“…Several recent studies have provided evidence that chronic treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine can facilitate synaptic plasticity (e.g., ocular dominance shifts) in the adult central nervous system. …”
Get full text

Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…We provide an insight into the role Drosophila has played in elucidating neurophysiological perturbations associated with Parkinson’s disease- (PD-) related genes. Synaptic signalling deficits are observed in motor, central, and sensory systems. …”
Get full text

From light sensing to adaptive learning: hafnium diselenide reconfigurable memcapacitive devices in neuromorphic computing by Bashayr Alqahtani, Hanrui Li, Abdul Momin Syed, Nazek El-Atab

“…Although charge-based or emerging memory technologies such as memristors have been developed to emulate synaptic plasticity, replicating the key functionality of neurons—integrating diverse presynaptic inputs to fire electrical impulses—has remained challenging. …”
Get full text

Identification of Neurons Containing Calcium-Permeable AMPA and Kainate Receptors Using Ca2+ Imaging by Sergei Gaidin, Artem Kosenkov, Valery Zinchenko, Bakytzhan Kairat, Arailim Malibayeva, Sultan Tuleukhanov

“…Calcium-permeable AMPA receptors (CP-AMPARs) and kainate receptors (CP-KARs) play crucial roles in synaptic plasticity and are implicated in various neurological processes. …”
Get full text

A light-driven device for neuromorphic computing by Shimul Kanti Nath

“…Abstract A unique optoelectronic synaptic device has been developed, leveraging the negative photoconductance property of a single-crystal material system called Cs2CoCl4. …”
Get full text

Memory consolidation from a reinforcement learning perspective by Jong Won Lee, Min Whan Jung, Min Whan Jung

Get full text

A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation by R. N. Mustafin

“…Therefore, long-term memory is preserved after elimination of synaptic connections. This is confirmed by the fact that the proteins involved in memory formation, including the transfer of genetic information through synapses between neurons (Arc protein), originate from transposons. …”
Get full text

Investigation of Cortical Signal Propagation and the Resulting Spatiotemporal Patterns in Memristor-Based Neuronal Network by Ke Ding, Zahra Rostami, Sajad Jafari, Boshra Hatef

“…It also is reported to be able to emulate synaptic long-term plasticity as well as short-term plasticity. …”
Get full text

Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair by Natalia Perussi Biscola, Luciana Politti Cartarozzi, Rui Seabra Ferreira Junior, Benedito Barraviera, Alexandre Leite Rodrigues de Oliveira

“…Coaptation preserved synaptic covering on lesioned motoneurons and led to neuronal survival. …”
Get full text

A Single Electrode Organic Neuromorphic Device for Dopamine Sensing in Vivo by Federico Rondelli, Michele Di Lauro, Gioacchino Calandra Sebastianella, Anna De Salvo, Matteo Genitoni, Mauro Murgia, Pierpaolo Greco, Carolina Giulia Ferroni, Riccardo Viaro, Luciano Fadiga, Fabio Biscarini

“…., with pulsed driving voltages), thus mimicking synaptic plasticity phenomena, offers promising and largely unexplored possibilities for bio‐sensing. …”
Get full text