Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…RNA sequencing data from mouse neural progenitor cells (mNPCs) showed that the genes regulating trans-synaptic signaling, transmembrane transport, and neuronal projection development were significantly decreased in Clcn4 knockdown (KD) cells compared to wild type (WT). …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…The role of EETs in synaptic function in the central nervous system is still largely unknown. …”
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Dendritic excitations govern back-propagation via a spike-rate accelerometer by Pojeong Park, J. David Wong-Campos, Daniel G. Itkis, Byung Hun Lee, Yitong Qi, Hunter C. Davis, Benjamin Antin, Amol Pasarkar, Jonathan B. Grimm, Sarah E. Plutkis, Katie L. Holland, Liam Paninski, Luke D. Lavis, Adam E. Cohen

“…We mapped sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. …”
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Spindle Activity Orchestrates Plasticity during Development and Sleep by Christoph Lindemann, Joachim Ahlbeck, Sebastian H. Bitzenhofer, Ileana L. Hanganu-Opatz

“…Along with these functional differences, separate synaptic plasticity mechanisms seem to be recruited. …”
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First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale by Kimberly L. Desmond, Anton Lindberg, Armando Garcia, Junchao Tong, Michael B. Harkness, Elena Dobrota, Kelly Smart, Carme Uribe, Jeffrey H. Meyer, Sylvain Houle, Antonio P. Strafella, Songye Li, Yiyun Huang, Neil Vasdev

“…[18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration. …”
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Spike reliability is cell type specific and shapes excitation and inhibition in the cortex by Simone Russo, Garrett B. Stanley, Farzaneh Najafi

“…Leveraging large-scale intracellular electrophysiological data, we relate the spiking reliability of cortical neurons in-vitro during the intracellular injection of current resembling synaptic inputs to their morphologic, electrophysiologic, and transcriptomic classes. …”
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Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection by Yoko Ozawa, Toshihide Kurihara, Kazuo Tsubota, Hideyuki Okano

“…In diabetic retinopathy, angiotensin II type 1 receptor (AT1R) signaling activates ERK in the inner layers of the retina, causing UPS-mediated excessive degradation of the synaptic vesicle protein, synaptophysin. This latter effect may decrease synaptic activity, in turn adversely affecting neuronal survival. …”
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Nonlinear time series prediction algorithm based on AD-SSNET for artificial intelligence–powered Internet of Things by Banteng Liu, Wei Chen, Meng Han, Zhangquan Wang, Ping Sun, Xiaowen Lv, Jiaming Xu, Zegao Yin

“…Finally, the reservoir synaptic matrix is calculated according to the synaptic information. …”
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Microglia and Synapse: Interactions in Health and Neurodegeneration by Zuzana Šišková, Marie-Ève Tremblay

“…However, in neurodegenerative diseases that are associated with misfolding and aggregation of synaptic proteins, these vital defensive functions appear to be compromised. …”
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Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction by John W. Wright, Joseph W. Harding

“…It is presumed that while these ECM proteins are weakened, and/or detached, synaptic connections can form resulting in new neural pathways. …”
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Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease by María José Pérez, Rodrigo A. Quintanilla

“…Furthermore, studies on animal models have shown that TZDs inhibit neuroinflammation, facilitate amyloid-β plaque clearance, enhance mitochondrial function, improve synaptic plasticity, and, more recently, attenuate tau hyperphosphorylation. …”
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Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse by Egidio D'Angelo, Paola Rossi

“…The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended. …”
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The transcriptional response of cortical neurons to concussion reveals divergent fates after injury by Mor R. Alkaslasi, Eliza Y. H. Lloyd, Austin S. Gable, Hanna Silberberg, Hector E. Yarur, Valerie S. Tsai, Mira Sohn, Gennady Margolin, Hugo A. Tejeda, Claire E. Le Pichon

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The endocytic adaptor AP-2 maintains Purkinje cell function by balancing cerebellar parallel and climbing fiber synapses by Marianna Tolve, Janine Tutas, Ebru Özer-Yildiz, Ines Klein, Anne Petzold, Veronika J. Fritz, Melina Overhoff, Quinn Silverman, Ellie Koletsou, Filip Liebsch, Guenter Schwarz, Tatiana Korotkova, Silvana Valtcheva, Graziana Gatto, Natalia L. Kononenko

“…These findings highlight the role of AP-2 in regulating GRID2IP levels in Purkinje cells to maintain PF-CF synaptic balance and prevent motor dysfunction.…”
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G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis by Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan

“…Summary: Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. …”
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Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets by Egor Dzyubenko, Christine Gottschling, Andreas Faissner

“…The components of the ECM have been detected near glial processes, which abut onto the CNS synaptic unit, where they are part of the specialized macromolecular assemblies, termed perineuronal nets (PNNs). …”
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Cellular Nanointerface of Vertical Nanostructures: Impact of Size‐Modulated Nanopillar Arrays on Neuronal Morphology, Maturation, and Synapse Formation by Younghak Cho, Suyeon Kim, Hui Jae Cho, Hyunju Ham, Kyung Eun Lee, Hyun Wook Kang, Young Woo Jeong, Jae‐Hyuk Ahn, Nakwon Choi, Joon Ho Kang, Aram J. Chung, Hyejeong Seong

“…These topography‐driven changes are attributed to the degree of cell confinement on NPs, which can be visualized using focused ion beam scanning microscopy. Furthermore, the synaptic density in cortical neurons declines as the S/D ratio decreases, with neurons preferring to form synapses along the NPs. …”
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An Area-Efficient Integrate-and-Fire Neuron Circuit with Enhanced Robustness against Synapse Variability in Hardware Neural Network by Arati Kumari Shah, Kannan Udaya Mohanan, Jisun Park, Hyungsoon Shin, Eou-Sik Cho, Seongjae Cho

“…Here, practical neuron circuits must overcome the variations arising from nonideal behaviors of synaptic devices, such as stuck-at-fault and conductance deviation. …”
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Immune Challenge Alters Reactivity of Hippocampal Noradrenergic System in Prenatally Stressed Aged Mice by Gayane Grigoryan, Niklas Lonnemann, Martin Korte

“…A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. …”
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Cd99l2 regulates excitatory synapse development and restrains immediate-early gene activation by Minji Kang, Sang Ho Yoon, Minkyung Kang, Seung Pyo Park, Woo Seok Song, Jungho Kim, Seungha Lee, Da-ha Park, Jae-man Song, Beomsue Kim, Kyung Hee Park, Eun-Hye Joe, Hyun Goo Woo, Seong Hoe Park, Bong-Kiun Kaang, Dohyun Han, Yong-Seok Lee, Myoung-Hwan Kim, Young Ho Suh

“…Based on these findings, we propose that neuronal Cd99l2 functions as a synaptic cell adhesion molecule that inversely controls neuronal activation.…”
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