Co-producing a safe mobility and falls informatics platform to drive meaningful quality improvement in the hospital setting: a mixed-methods protocol for the insightFall study by Ben Glampson, Clare Leon-Villapalos, Erik Mayer, Rachael Lear, Phoebe Averill, Catalina Carenzo, Rachel Tao, Robert Latchford

“…Exploratory analysis of a preliminary static dataset will examine the variety (structured/unstructured), veracity (accuracy/completeness) and value (clinical utility) of the data. …”
Get full text

Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

“…The findings suggest that citrulline effectively inhibits PDE5 in a non-competitive manner, with higher binding affinity and greater structural stability than sildenafil, highlighting its potential as a more stable and efficient PDE5 inhibitor. …”
Get full text

<i>Limosilactobacillus reuteri</i> ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Chal... by Xin Xu, Hongwei Zhang, Kun Meng, Hongying Cai, Weiwei Liu, Liye Song, Zihan Zhang, Qijun Zhu, Xiling Han, Yunsheng Han, Peilong Yang

“…Additionally, it significantly altered the structure of gut microorganisms by enriching <i>Akkermansia</i> and <i>Clostridia_UCG.014</i>, and thereby re-establishing colonization resistance and alleviating ETEC K88-induced intestinal barrier damage and inflammation in mice. …”
Get full text

Literature review: potential non-thermal molecular effects of external radiofrequency electromagnetic fields on cancer by Anna Dieper, Stephan Scheidegger, Rudolf M. Füchslin, Paraskevi D. Veltsista, Ulrike Stein, Mathias Weyland, Dominik Gerster, Marcus Beck, Olof Bengtsson, Daniel Zips, Pirus Ghadjar

“…Among those, by reviewing the included publications, we identified RF-EMF-induced ion channel activation, altered gene expression, altered membrane potentials, membrane oscillations, and blebbing, as well as changes in cytoskeletal structure and cell morphology.Conclusion The existent literature points toward a yet untapped therapeutic potential of RF-EMF treatment, which might aid in damaging cancer cells through bio-electrical and electro-mechanical molecular mechanisms while minimizing adverse effects on healthy tissue cells. …”
Get full text

Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses by Rafael Bayarri-Olmos, Rafael Bayarri-Olmos, Adrian Sutta, Adrian Sutta, Anne Rosbjerg, Anne Rosbjerg, Mie Mandal Mortensen, Charlotte Helgstrand, Per Franklin Nielsen, Laura Pérez-Alós, Beatriz González-García, Laust Bruun Johnsen, Finn Matthiesen, Thomas Egebjerg, Cecilie Bo Hansen, Alessandro Sette, Alessandro Sette, Alba Grifoni, Ricardo da Silva Antunes, Peter Garred, Peter Garred

“…Notably, we identified two glycan sites (N717 and N801) as potentially essential for the structural integrity of the spike protein. We also evaluated the antibody and T cell responses. …”
Get full text

Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…The constructed quantitative structure–activity relationship model with a trustworthy R 2 coefficient value supports the inhibition prowess of these compounds. …”
Get full text

A holistic review of nanomaterials in strain-hardening cementitious composites: Insights into micro- and macromechanical, deformation, smart, and durability properties by Isyaka Abdulkadir, Leong Sing Wong, Lee Woen Ean, G. Murali, Bashar S. Mohammed

“…These mechanisms include refining the pore structure, improving the interfacial transition zone (ITZ) between the fibers, cementitious matrix, and aggregates, and providing additional nucleation sites for cement hydration products. …”
Get full text

Integrated Assessment of the Quality of Functioning of Local Electric Energy Systems by Waldemar Wójcik, Petro Lezhniuk, Cezary Kaczmarek, Viacheslav Komar, Iryna Hunko, Nataliia Sobchuk, Laura Yesmakhanova, Zhazira Shermantayeva

“…The sources of electricity in LEESs are small hydroelectric power plants (SHPPs), photovoltaic power plants (PVPPs), and wind power plants (WPPs), whose electricity generation is unstable due to dependence on natural conditions. Therefore, the structure of a LEES with RSE includes an energy storage system with reserves sufficient to compensate for the unstable generation and balancing of the mode. …”
Get full text

Parameter influences of FTO/ZnO/Cu₂O photodetectors fabricated by electrodeposition and spray pyrolysis techniques by Muthiah N. Najah, Frida A. Rahmania, Integralita Cahyanti, Maulida Hesnaty, Siti Hajar Alias, Djoko Hartanto, Wahyu Prasetyo Utomo, Retno Sari, Hadi Nur

“…The FTO layers were produced via spray pyrolysis, with optimal deposition achieved at 400 °C and efficiency value 0.0149 %, resulting in a dense, transparent structure. Meanwhile the efficiency of samples at temperatures of 350°C, 450°C, and 500°C are 0.0032 %, 0.0042 %, and 0.0037 %. …”
Get full text

The efficacy of neoadjuvant immunotherapy and lymphocyte subset predictors in locally advanced esophageal squamous cell carcinoma: A retrospective study by Ruotong Wang, Shaodi Wen, Xiaoyue Du, Jingwei Xia, Bowen Hu, Yihan Zhang, Guoren Zhou, Feng Jiang, Xiaomin Lu, Miaolin Zhu, Xinyu Xu, Bo Shen

“…We assessed peripheral blood indexes and tertiary lymphoid structures (TLS) density to evaluate their impact on pathological response and prognosis, leading to a clinical prediction model for treatment efficacy and survival. …”
Get full text

Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon by Lucy Cho Nchang, Chefor Magha, Patience Agwa Fonong, Narcisse Victor Tchamatchoua Gandjui, Nancielle Mbiatong Tchatat, Desmond Akumtoh Nkimbeng, Frank Noel Nietcho, Juluis Visnel Foyet, Fanny Fri Fombad, Tatiana Djikeussi Katcho, Jerome Fru Cho, Achim Hoerauf, Manuel Ritter, Samuel Wanji

“…Socio-demographic data and associated factors were collected using structured questionnaires. Blood, stool, urine and skin snip samples were collected following standard guidelines for investigation of parasitic infections. …”
Get full text

The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 1; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

“…A sample of participants will also be invited to a semi-structured interview to discuss their experience. The primary comparative analysis will be according to randomised allocation regardless of actual frequency of bathing. …”
Get full text

Physiological and multi-omics analysis revealed the mechanism of arbuscular mycorrhizal fungi to cadmium toxicity in green onion by Kunhao Xie, Yixuan Chen, Xiaoqin Wang, Xiaoya Zhou, Yizhe Cheng, Xianchang Yu, Jun Wang, Mintao Sun, Yansu Li, Chaoxing He

“…AMF formed an effective symbiotic relationship with green onion roots under Cd stress, increased plant biomass, improved root structure and enhanced root vitality. AMF-colonized green onion had reduced Cd content in roots and leaves by 63.00 % and 46.50 %, respectively, with Cd content being higher in the roots than in the leaves. …”
Get full text

Zinc lysine and selenium yeast can effectively improve the reproductive performance of Northeast white geese by Jingchun Li, Heze Feng, Yulun Song, Hechuan Wang, Yingying Dong, Han Li, Qing Guo, Shengjun Liu, Yanbing Li

“…The aim of this study was to investigate the effects of dietary supplementation with selenium yeast (YS) and zinc lysine (ZL) on goose semen quality, testicular tissue structure, reproductive hormone levels, antioxidant capacity and egg fertilization rate. …”
Get full text

Establishment of <i>Echinococcus granulosus EgM123</i> Recombinant Gene Rabies Virus SRV₉ and Identification of Its Biological Characteristics by Yueqi Yang, Mengdan Hou, Guicheng Su, Xiaoyan Ma, Xiaohui Su, Kunlei Li, Songhan Liu, Luheng Xiao, Jingjing Yao, Jiahao Zhai, Xiaoying Wei, Yang Zhou, Qianqian Lai, Yuwei Dong, Jieyu Liu, Shaohua Zhai

“…The rescued virus-infected BSR cells were characterized by TEM, and the results indicated that bullet-like viral particles with an average size of 148.47 nm and a cyst structure were present in the cytoplasm of BSR cells; the expression levels of continuously cultivated 9th-, 10th-, 11th-, 12th-, and 13th-generation viruses were quantified by qRT-PCR, and the results showed that mRNA expression of the virus was upregulated. …”
Get full text

Study on the application of thermal-meltable recovery of CFRP strand anchors by Yize Zuo, Yize Zuo, Shanchang Xu, Shanchang Xu, Xin Fan, Weiwei Liu, Shuai Guan, Ruixin Jia, T. Tafsirojjaman

“…The recovered CFRP strands were clean, with no resin residue, and had no damage, maintaining an intact structure. The proposed thermoplastic CFRP prestressed strand design demonstrates significant advantages in anchoring strength and recoverability. …”
Get full text

Development of a pandemic-related core set of quality indicators for quality and patient safety in University Hospitals in Germany by Janis Evers, Natalie Altschuck, Claudia Mehl, Lilly Rüthrich, Lorenz Harst, Felix Walther, Oliver Steidle, Arnt Suckow, Ruth Hecker, Jochen Schmitt, Max Geraedts

“…The study contributes to quality management in healthcare during pandemics by creating the basis for a structured approach to pandemic preparedness and response. …”
Get full text

Effects of nano-selenium and/or vitamin E supplementation on growth performance, antioxidant status, histopathology and resistance to Aspergillus flavus in Nile tilapia (Oreochromi... by Walaa K. Bazina, Wesam A. Tawfik, Nadia A. Abd Elghany, Saadea Saadony, Zulhisyam Abdul Kari, Muna Omer Alamoudi, Mohamed Y. M. Aly, Abuelhassan Elshazly Younis, Roshmon Thomas Mathew, Moaheda E. H. Eissa, Mohammad Bodrul Munir, Saadiah Ibrahim, Ismail Yousef, Yusuf O. H. Omar, El-Sayed Hemdan Eissa, Heba E. Abd Elnabi

“…Histopathological analysis revealed somewhat lacerated gill arches in fish fed SeNPs, VE, or their combination, but the overall gill structure remained normal. The SeNPs + VE group exhibited improved villi length and normal morphology of portal veins and hepatic sinusoids, though some vacuolated hepatocytes were noted. …”
Get full text

The Role of P‐Wave Variables in Enhancing Prediction of New‐Onset Atrial Fibrillation in Patients With Acute Myocardial Infarction by Na Yang, Xiaoyan Li, Bo Wu, Longhao Dai, Shaobin Yang, Qinning Zhang, Shaobin Jia

“…Some P‐wave variables (P‐wave duration [PWD], P‐wave amplitude, and interatrial block [IAB]), reflecting the process of electrical and structural remodeling, could predict the risk of atrial fibrillation (AF). …”
Get full text

Impact of mother’s own milk expression practices and processing treatments on infant health and growth outcomes: a systematic review protocol by Daniel Klotz, Carolyn Smith, Agnieszka Bzikowska-Jura, Marzia Giribaldi, Tanya Cassidy, Laura Cavallarin, Serena Gandino, Karolina Karcz, Chiara Peila, Bartłomiej Walczak, Aleksandra Wesolowska

“…We will apply a hybrid search strategy, by combining structured database search with predefined snowballing searches. …”
Get full text