Analysis of the practice of switch of antibiotics from intravenous to oral therapy at a tertiary care hospital in Nepal: a prospective observational study by Upasana Acharya, Sweta Shrestha, Aastha Rawal, Laxmi Dangol, Binaya Sapkota

“…There is a need for the implementation of structured program to review patients on IV antibiotics and promote timely conversion to oral once they meet the conversion criteria. …”
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Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy by Wenhua Zhang, Zeyuan Qiang, Hao Song, Xiaoli Li, Handong Dan, Keke Ge, Pan Li, Zixu Huang, Dongdong Wang, Feng Chen, Bin Zheng, Zongming Song

“…Best-corrected visual acuity (BCVA), tumor activity, retinal morphological structure, and postoperative complications were evaluated. …”
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Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy by Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Takuya Ishikawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Masatoshi Ishigami, Mitsuhiro Fujishiro

“…Half of the patients had a history of cerebrovascular and cardiovascular disease. A granular structure at the ulcer base was the most frequently observed DBE finding at the stenotic site. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…Finally, we explore the impact of biofilm formation, a classical virulence attribute of fungi, on antifungal resistance, highlighting the resistance mechanisms associated with this complex microbial structure that have been uncovered to date.…”
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Effect of Modulating Spin-Coating Rate of TiO2 Precursor for Mesoporous Layer on J-V Hysteresis of Solar Cells with Polar CH3NH3PbI3 Perovskite Thin Film by Qi Li, Xiaoping Zou, Yuanyuan Li, Yaxian Pei, Shuangxiong Zeng, Dongdong Guo

“…Finally, the hysteresis index for the 1500 rpm mesostructured solar cell shows relatively low J-V hysteresis compared with the 3000 rpm mesostructured and the planar-structured solar cell. Our experimental results bring novel routes for reducing the hysteresis and investigating the polar nature for CH3NH3PbI3 material.…”
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Heterogeneous graph convolutional neural network for protein-ligand scoring by Kevin Crampon, Alexis Giorkallos, Xavier Vigouroux, Stephanie Baud, Luiz Angelo Steffenel

“…Computational simulations like molecular docking enable fast exploration of large databases of compounds and extract the most promising molecule candidates for further in vitro and in vivo tests. Structure-based molecular docking is a complex process mixing both surface exploration and energy estimation to find the minimal free energy of binding corresponding to the best interaction location. …”
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State of the Art Compendium: Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease by Denis E O’Donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Francois Maltais, Jeremy Road

“…Patients with advanced COPD and respiratory failure require a comprehensive management plan that incorporates structured end-of-life care. Management strategies, consisting of combined modern pharmacotherapy and nonpharmacotherapeutic interventions (eg, pulmonary rehabilitation and exercise training) can effectively improve symptoms, activity levels and quality of life, even in patients with severe COPD.…”
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Valorization of rice stubble through biodegradation using hydrolytic enzyme-producing Olivibacter oleidegradans CMB10 and Agrobacterium pusense SFMB9 by Milind Gajbhiye, Sushmita Patil, Sagar Awate, Supriya Kokare, Siddharth Terdale, Manish Kumar Dubey

“…Scanning electron microscopic images confirm the distortion of microfibrillar structure of stubble by cultures. The activity of all hydrolytic enzymes was detected on all the days post-inocualtion, where, cellulase activity was at the highest (95.77 U/ml). …”
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Microbial community differentiation in vent chimneys of the Lost City Hydrothermal Field reflects habitat heterogeneity by Osama M. Alian, William J. Brazelton, Karmina A. Aquino, Katrina I. Twing, H. Lizethe Pendleton, Gretchen Früh-Green, Susan Q. Lang, Matthew O. Schrenk, Matthew O. Schrenk

“…Although many species are found in both chimneys and venting fluids, the overall microbial community structures in chimney biofilms remain distinct from the hydrothermal fluids that flow through them. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. …”
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Analysis and Verification of a Slope Steering Model of TRVs in Hilly and Mountainous Environments by Luojia Duan, Kaibo Kang, Shiying Chen, Zixing Du, Longhai Zhang, Zhijie Liu, Fuzeng Yang, Zheng Wang

“…This study establishes a slope steering model for tracked robotic vehicles based on a ground pressure model of the multi-peak varying amplitude cosine distribution and the shearing displacement relationship between the track and the ground, and analyzes the impact of vehicle structural parameters, road surface parameters, and steering parameters on steering performance. …”
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Explainable AutoML models for predicting the strength of high-performance concrete using Optuna, SHAP and ensemble learning by Muhammad Salman Khan, Tianbo Peng, Tianbo Peng, Muhammad Adeel Khan, Asad Khan, Mahmood Ahmad, Mahmood Ahmad, Kamran Aziz, Mohanad Muayad Sabri Sabri, N. S. Abd EL-Gawaad

“…This approach provides civil engineers with a robust and interpretable tool for optimizing HPC properties, reducing experimentation costs, and supporting enhanced decision-making in structural design, risk assessment, and other applications.…”
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Postnatal expression of Cat-315-positive perineuronal nets in the SAMP10 mouse primary somatosensory cortex by Hiroshi Ueno, Yu Takahashi, Sachiko Mori, Eriko Kitano, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

“…Furthermore, using SAMP10 will be useful in elucidating the mechanism of age-related abnormalities in brain function as well as in elucidating the function and structure of PNNs.…”
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A Hybrid Efficient U-Net Framework for Detection of Anterior Belly of the Digastric Muscle on Ultrasonography by Sule Erdem, Suheda Erdem, Muammer Turkoglu, Abdulkadir Sengur, Nebras M. Sobahi

“…The model can contribute to clinical diagnostic processes with its ability to accurately detect small and large structures. Future studies can increase the generalization capacity of the model by testing it in different modalities.…”
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The compressive strength development and pH of cement mortars incorporating high volume supplementary cementitious materials under accelerated curing by Sumra Yousuf, Muhammad Rizwan, Belal Alsubari, Mustabshirha Gul, Muhammad Mahmood Ali, Muhammad Nasir Bashir, Abid Latif

“…The durability and service life of concrete structures is primarily dependent on the performance of cement-based material (CBM). …”
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Application of copy number variation sequencing combined with whole exome sequencing in prenatal left–right asymmetry disorders by Yu Qin, Muon Senglong, Koksear Touch, Juan Xiao, Ruijie Fang, Qingling kang, Lei Fan, Shufang Li, Jing Liu, Jianli Wu, Yuanyuan Wu, Xinwei Shi, Haiyi Liu, Xun Gong, Xingguang Lin, Ling Feng, Suhua Chen, Wei Li

“…Further bioinformatics scrutiny was conducted to assess the protein structure and function prediction of these variants, ultimately indicating their potential pathogenicity. …”
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Big Data Governance Challenges Arising From Data Generated by Intelligent Systems Technologies: A Systematic Literature Review by Yunusa Adamu Bena, Roliana Ibrahim, Jamilah Mahmood, Arafat Al-Dhaqm, Ahmad Alshammari, Maged Nasser, Muhammed Nura Yusuf, Matthew O. Ayemowa

“…The BDG MAM evaluates governance maturity across four key dimensions: people, process, data, and technology. It provides a structured roadmap for organizations to benchmark governance practices, prioritize improvements, and implement effective strategies. …”
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Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

“…We applied these methods to evaluate condensation of the SARS-CoV-2 nucleocapsid (N) protein under GSK3 inhibitor treatment, which we had previously identified in our HCS campaign to induce condensation with well-defined structure-activity relationships (SAR). Using htSMT, we observed robust changes in N protein diffusion as early as 3 h post GSK3 inhibition. …”
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Treatment of a medial plica in the knee among German knee surgeons – The Plica Survey by Svea Faber, Philipp W. Winkler, Ralf Henkelmann, Theresa Diermeier, Wolf Petersen, Maurice Balke, Sebastian Metzlaff, Sebastian Colcuc, Gerald Zimmermann, Philip P. Roessler, Thomas R. Niethammer

“…While often an anatomical relic without pathological significance, inflammation or mechanical irritation of this structure can lead to plica syndrome, causing significant clinical symptoms. …”
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Designing and explaining the improvement model of women's employability capacity with emphasis on the 7th development plan by Mahsa Vahidpour, Akbar Etebarian Khorasgani, Mehrban Hadi Peykani, Saeed Daei-Karimzadeh

“…This qualitative research was compiled using thematic analysis; in this research, using semi-structured interviews with 23 experts in the field of policy making, entrepreneurship and management, the findings were combined and the present model was designed. …”
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