Demethylnobiletin and its major metabolites: Efficient preparation and mechanism of their anti-proliferation activity in HepG2 cells by Yanping Xin, Ting Zheng, Man Zhang, Ruiqiang Zhang, Siyue Zhu, Dongli Li, Denggao Zhao, Yanyan Ma, Chi-Tang Ho, Qingrong Huang

“…In this study, an efficient chemical synthetic method was developed to obtain 5-DMN and its 3 metabolites, and their molecular structures were confirmed by 1H NMR and LC-MS. Cytotoxicity, cell cycle arrestment, apoptosis and caspase-3 expression were investigated to evaluate the anti-liver cancer effects of these OH-PMFs on HepG2 cells. …”
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Role of acute respiratory diseases in pathogenesis of distal limb infections in cattle by A. D. Alekseev, O. G. Petrova, M. I. Barashkin, I. M. Milshtein, V. D. Moskvin

“…Low molecular weight circulating immune complexes settle in various organs and tissues of the body, lead to inflammation and damage the normal tissue structure. Most frequently, immune complexes affect the endothelium of blood vessels, renal glomeruli and joints. …”
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How to transform cultivated land protection on the Northeast Tibetan Plateau？ A multifunctional path exploration by Rongrong Ma, Yuhan Huang, Wei Zhou, Jun Ren, Hongyu Wang, Zeyu Shi, Juan Wang

“…Correlation analysis and a coupled coordination degree model are used to understand the intrinsic structural characteristics that impact the multifunctionality of CLs. …”
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Streaming Torque with Turbulent Diffusion by Qiang Hou, Cong Yu

“…The dust diffusion will smooth the short-wavelength structure of the the quasi-drift mode and split it into two predominant D-drift modes with opposite directions. …”
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A comprehensive review of AI-based collagen valorization: Recent trends, innovations in extraction, and applications by Arthi Srinivasan, Arun Gupta, Vigneswaran Narayanamurthy

“…Collagen, constituting approximately 30 % of total body proteins, is a critical structural protein with extensive applications in biomedical, cosmetic, and food industries. …”
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Long-term Spectral Monitoring of Active Asteroid (6478) Gault: Implications for the H Chondrite Parent Body by Adam Battle, Vishnu Reddy, Juan A. Sanchez, Neil Pearson, Benjamin N. L. Sharkey, Theodore Kareta

“…The low-level thermal metamorphism interpretation of Gault’s surface suggests that it formed from the outermost portion of the progenitor of the Phocaea family, assuming an “onion shell’ structure, which was catastrophically disrupted 1.2 Gyr ago. …”
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RBD-displaying OMV nanovaccine boosts immunity against SARS-CoV-2 by Rang Feng, Ruo-Yi Xue, Chang Liu, Guo-Cheng Li, Yan Deng, Zhe Jin, Jing-Yi Liu, Shan-Shan Zhang, Hao Cheng, Man-Ying Guo, Quan-Ming Zou, Hai-Bo Li

“…Outer membrane vesicles (OMVs), secreted by Gram-negative bacteria, are nanospherical structures that can display or deliver antigens while also providing adjuvant activity through pathogen-associated molecular patterns (PAMPs). …”
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Precision Adverse Drug Reactions Prediction with Heterogeneous Graph Neural Network by Yang Gao, Xiang Zhang, Zhongquan Sun, Payal Chandak, Jiajun Bu, Haishuai Wang

“…Next, a GNN‐based model is utilized to learn latent representations of the patient nodes and facilitate the propagation of information throughout the graph structure. By employing patient embeddings that consider their diseases and drugs, potential ADRs can be accurately predicted. …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. …”
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Blood Glucose Lowering Efficacy of Strawberry Extracts Rich in Ellagitannins with Different Degree of Polymerization in Rats by Juśkiewicz Jerzy, Jurgonski Adam, Kołodziejczyk Krzysztof, Kosmala Monika, Milala Joanna, Zduńczyk Zenon, Fotschki Bartosz, Żary-Sikorska Ewa

“…The results clearly showed that the separate mechanisms (glucose transport across the intestine, intestinal mucosal disaccharidases inhibition activity, pancreatic α-amylase inhibitory activity) leading to decreased postprandial glycaemia upon dietary administration of strawberry ellagitannins largely depended on their chemical structure, i.e. degree of polymerization.…”
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Two novel entomopathogenic fungal species of Lecanicillium isolated from soil in China by Tongyi Liu, Wei Chen, Yanhong Tang, Fen Liu, Liyan Yao, Qiongbo Hu, Ke Zhang, Qunfang Weng

“…They differ from known closely related species primarily in sporulation structure, conidia and colony morphological characteristics, and sequence variations in the LSU, SSU, ITS, and TEF gene regions of the ribosomal DNA. …”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Mechanistic insights were further gained through DNA methylation profiling and chromatin structure analysis. Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. …”
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Using stone dust as an improvement material for cement gravel column by Raksiri Sukkarak, Pornkasem Jongpradist, Panich Voottipruex, Pitthaya Jamsawang, Suraparb Keawsawasvong, Teerawut Pansuwannakun, Ittipon Meepon

“…A cement gravel (CG) column was employed for ground improvement in foundation engineering, offering increased load-bearing capacity and structure stability. This research explores the feasibility of incorporating stone dust into cement gravel columns to enhance their mechanical properties and sustainability profile. …”
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Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities by Wei Gao, Shuyi Chen, Xin Yu, Sumin Chen, Caijing Wan, Ying Wang, Peng Wu, Qiang Li

“…Following the planting of the three types of ecologically restored plants, the soil bacterial community structure partially recovered. In addition, different plants have been found to have different functions in the lead-zinc ecological restoration process, including iron complex transport system-permitting proteins and ATP binding cassettes.DiscussionThis study confirms for the first time that plants adapt to the remediation process of abandoned lead-zinc mines by non-randomly assembling rhizosphere bacterial communities and functions, providing a reference for screening microbial remediation bacterial resources and plant microbe joint bioremediation strategies for lead-zinc mines.…”
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Strategic SWOT analysis of the University of Nigeria Teaching Hospital using Modified Delphi Technique: implications for strengthening national and regional health systems by Cyril Chukwudi Dim, Chinyere Ojiugo Mbachu, Nympha Onyinye Enebe, Wilson Chukwukasi Kassy, Johnpaul Ejikeme Nnagbo, Ikechukwu Emmanuel Obi, Nkiruka Pauline Onodugo, Nwamaka Ngozika Lasebikan, Obinna Donatus Onodugo

“…This was followed by a structured ranking of the SWOTs by 109 staff of UNTH to isolate the priority assets and needs of the organization. …”
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Characterizing a complex buildup in the Pearl River Mouth Basin of the northern South China Sea: an interplay of carbonates and igneous rocks by Beichen Chen, Leyi Xu, Baojun Liu, Lili Zhang, Dong Xiao, Ya Gao, Ya Gao, Feng Wu, Xueqi Yang, Yaming Zou, Yongkun Ma, Yinglin Zhang

“…We propose that volcanic rocks can be distinguished from carbonates by the temporal and spatial coupling of typical features: (a) surface volcanic rocks and subsurface intrusive bodies are inseparable, with igneous rocks identifiable through faults and volcanic conduits; (b) carbonates typically display symmetrical structures on both sides of the highland and exhibit better stratification away from igneous activity; (c) carbonates generally show a convex clinoform and steep slope at the platform margin, while volcanic mounds exhibit concave gentle slopes. …”
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Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F by P. H. Voermans, K. G. Go, G. J. Ter Horst, M. H. J. Ruiters, E. Solito, L. Parente

“…An opposite profile was shown by the Anx-1 immunoreactivity, the protein was present in control animals as well as the steroid-pretreated animals, suggesting that here the protein was either from systemic origin, or has diffused from adjacent structures. The results indicated that Anx-1 mRNA transcription is upregulated by either steroid, and that in the untreated animals there is a resting level of Anx-1 mRNA transcription, presumably reflecting physiological influences on Anx-1 expression.…”
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Agroecological mapping of livestock feed resources for sustain productivity and climate resilience in Benin (West Africa) by Marthe Montcho, Alassan S. Assani, Jean de Dieu Ainamon, André B. Aboh, Pascal A. Olounladé, Brice Sinsin

“…Data were collected through discussions with agropastoralists, structured questionnaires, secondary data and observations. …”
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Stakeholders’ Views on Factors Influencing Nutrition Policy: a Qualitative Study Across Ten European Countries by Jeruszka-Bielak Marta, Sicińska Ewa, Wit Liesbeth de, Ruprich Jiří, Řehůřková Irena, Brown Kerry A., Timotijevic Lada, Sonne Anne-Mette, Haugaard Pernille, Guzzon Antonella, Garcia Noé Brito, Alevritou Eleni, Hermoso Maria, Sarmant Yuliya, Lähteenmäki Liisa, Roszkowski Wojciech, Raats Monique M.

“…Study was carried out during Jan-Nov 2010 in European countries: the Czech Republic, Denmark, England, Germany, Greece, Italy, the Netherlands, Norway, Poland and Spain. Semi-structured qualitative interviews were conducted with representatives of stakeholders involved in the vitamin D, folate and iodine policy making process. …”
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Identification of Staphylococcus aureus, Enterococcus faecium, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii from Raman spectra by Artificial Intelligen... by Yu-Tzu Lin, Hsiu-Hsien Lin, Chih-Hao Chen, Kun-Hao Tseng, Pang-Chien Hsu, Ya-Lun Wu, Wei-Cheng Chang, Nai-Shun Liao, Yi-Fan Chou, Chun-Yi Hsu, Yu-Hui Liao, Mao-Wang Ho, Shih-Sheng Chang, Po-Ren Hsueh, Der-Yang Cho

“…Spectral differences between Gram-positive and Gram-negative bacteria were linked to structural variations in their cell walls, such as peptidoglycan and lipopolysaccharides. …”
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