Thiazolo-pyridopyrimidines: An in silico evaluation as a lead for CDK4/6 inhibition, synthesis and cytotoxicity screening against breast cancer cell lines by Chaithra R Shetty, C. S. Shastry, Parasuraman P, Srinivas Hebbar

“…Further enhancements to cytotoxic potential could be achieved through structural refinements.…”
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A Lightweight Network for Ship Detection in SAR Images Based on Edge Feature Aware and Fusion by Yuming Li, Jin Liu, Xingye Li, Xiliang Zhang, Zhongdai Wu, Bing Han

“…Despite certain achievements, there are still several limitations: 1) Existing studies have mainly focused on reducing model complexity through shallow network structures. However, this approach frequently results in performance degradation, as they neglected a thorough investigation into achieving a better balance point between inference speed and detection accuracy. 2) Under the lightweight network structure, the rich edge features contained in SAR images, which are crucial for distinguishing ship targets from complex backgrounds, are often underutilized. …”
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Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain by Marlen Reichenbach, Sven Richter, Roberta Galli, Matthias Meinhardt, Katrin Kirsche, Achim Temme, Dimitrios Emmanouilidis, Witold Polanski, Insa Prilop, Dietmar Krex, Stephan B. Sobottka, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ortrud Uckermann

“…Diffuse autofluorescence, fibers and round fluorescent structures were predominantly found in tumor tissues. …”
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In-vivo high-resolution χ-separation at 7T by Jiye Kim, Minjun Kim, Sooyeon Ji, Kyeongseon Min, Hwihun Jeong, Hyeong-Geol Shin, Chungseok Oh, Robert J. Fox, Ken E. Sakaie, Mark J. Lowe, Se-Hong Oh, Sina Straub, Seong-Gi Kim, Jongho Lee

“…The proposed method results well delineate the detailed brain structures associated with iron and myelin. This new pipeline holds promise for analyzing iron and myelin concentration changes in various neurodegenerative diseases through precise structural examination.…”
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The effect of Ta alloyed state on the corrosion resistance of TC4 surface laser cladding high entropy alloy by Feixiang Tian, Qiyu Gao, Leilei Wang, Xiaohu Guan, Xiaohong Zhan

“…The effects of Ta alloyed state on the phase structure, microstructure evolution, microhardness, corrosion resistance and passivation film of coatings were investigated. …”
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Study on the Construction Performance of Zeolite Asphalt Mixture Based on Macro-Micro Scale by Zhuolin Li, Junda Ren, Jianping Zhu, Wei Li, Xingsheng Fu, Liying Yang

“…In order to explore the construction performance of zeolite asphalt mixture, the microproperties of zeolite and the macroproperties of zeolite asphalt mixture were studied. The structure composition, surface properties, and pore characteristics of zeolite were analyzed by infrared spectroscopy and pressure pump method. …”
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Successful thoracoscopic-assisted resection of a functional paraganglioma in the mediastinum with extracorporeal circulation: a case report by Zhihui Yang, Xiaojie Huang, Danting Zhou, Tao Tang, Hengxing Liang, Wenliang Liu, Fenglei Yu, Chen Chen

“…This report details the surgical management of a complex mediastinal paraganglioma case, presenting with refractory hypertension and invasion of critical surrounding structures. A comprehensive review of the current literature is included to underscore existing cases, enhance clinical awareness, and share our insights and experience in the diagnosis and treatment of this challenging condition. …”
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Invasive Aspergillus niger Is the Sole Etiological Agent for CSOM : A Clinical Case from Nepal by Ajay Kumar Chaurasiya, Rabindra Bhakta Pradhananga, Niranjan Prasad Sah, Basista Prasad Rijal, Bharat Mani Pokhrel, Santosh Dulal

“…Thereafter, the fungal colony was investigated via a lactophenol cotton blue (LPCB) tease mount which displayed the structure of Aspergillus. Aspergillus niger was microbially conformed by specifically characterizing the specific phenotypic biseriate structure of phialides and the black-coloured conidia. …”
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Analysis on Rock Burst Risks and Prevention of a 54 m-Wide Coal Pillar for Roadway Protection in a Fully Mechanized Top-Coal Caving Face by Zhihua Li, Ke Yang, Jianshuai Ji, Biao Jiao, Xiaobing Tian

“…Results show that mining depth, geological structure, outburst proneness of coal strata, roof strata structure, adjacent mining area, and mining influence of the current working face are the main influencing factors of rock burst on the working face. …”
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Developing a master of science in health research ethics program in Northern Nigeria: a needs assessment by Caitlin Bieniek, Fatimah I. Tsiga-Ahmed, Aishatu L. Adamu, Usman J. Wudil, C. William Wester, Zubairu Iliyasu, Muktar H. Aliyu, Elisa J. Gordon, Elizabeth S. Rose

“…Methods To inform the creation of a Master of Science in Health Research Ethics program in northern Nigeria, we conducted a needs assessment comprised of semi-structured interviews with nine Nigerian bioethics experts. …”
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Analysis on ignition characteristics and stability of large length-diameter tube with high-low pressure chamber: Experimental and two-phase flow method research by Shenshen Cheng, Ruyi Tao, Xinggan Lu, Xiaoting Cui, Shao Xue

“…However, due to the restriction of the ignition process within the tube by the initial ignition source, the high-low pressure chamber structure is commonly adopted to ensure the ignition performance. …”
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ESTIMACIÓN DE EROSIÓN HIDRICA DE SUELOS PARA PLAN DE MANEJO DEL CAMPO FORESTAL AGUAS FRÍAS, PATAGONIA ARGENTINA by Ana C. Dufilho, María C. Frugoni, Pablo Macchi, Alan Toth

“…The mapping methodology was based in Hierarchical Classification of Landforms, which is the structure of the geopedology focus for mapping soil (Zinck, 1989). …”
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LIM-kinase 1 effects on memory abilities and male courtship song in Drosophila depend on the neuronal type by A. V. Zhuravlev, E. S. Zalomaeva, E. S. Egozova, A. D. Emelin, V. V. Sokurova, E. A. Nikitina, E. V. Savvateeva-Popova

“…Thus, LIMK1 effects on the Drosophila male memory and courtship song appeared to depend on the neuronal type or brain structure.…”
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Performance of sulfur/steel slag composite matrix in removing nitrate from surface water with low-carbon content by PENG Xianchun, ZHENG Lili, LU Haoran, WANG Zhefeng, ZHU Zheng, LIANG Wenyan

“…The analysis of microbial community structure showed that the microorganisms responsible for denitrification belonged to Proteobacteria and Bacteroidota. …”
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Barriers and enablers to recruiting participants within paediatric perioperative and anaesthetic settings: lessons learned from a trial of melatonin versus midazolam in the premedi... by Marie C. Hyslop, Diana E. Papaioannou, Robert Bolt, Matthew J. Wilson, Michael Bradburn, Janet Clarkson, Esther Herbert, Nicholas Ireland, Jennifer Kettle, Amanda Loban, Amy C. Norrington, Christopher Vernazza, Christopher Deery

“…As part of a qualitative sub-study, semi-structured interviews with local site teams, participants, and caregivers also explored barriers and enablers to recruitment. …”
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Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity by Aboli Bhingarkar, Yuyin Wang, Keito Hoshitsuki, Katherine Marie Eichinger, Katherine Marie Eichinger, Sanjay Rathod, Yin Zhu, He Lyu, Andrew T. McNutt, Larry W. Moreland, Lee McDermott, David R. Koes, Christian A. Fernandez

“…Therefore, developing a potent NFAT inhibitor to suppress this immunogenicity may offer an alternative to MTX.MethodsWe performed a structure-based virtual screen of the NFATC2 crystal structure to identify potential small molecules that could interact with NFATC2. …”
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Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease by Tristan Gabriel-Segard, Margherita Boltri, Mathilde Barrau, Catherine Massoubre, Stéphane Paul, Xavier Roblin

“…<b>Conclusions:</b> To tackle the question of fatigue in IBD, research should consider investigating the biological mechanisms implicating intestinal physiopathology of IBD in the impairment of brain structure involved in motivation. This may open new fields for treatment in targeting structures of the brain reward system.…”
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Toward an Efficient Differentiation of Two <i>Diaporthe</i> Strains Through Mass Spectrometry for Fungal Biotyping by Kathleen Hernández-Torres, Daniel Torres-Mendoza, Gesabel Navarro-Velasco, Luis Cubilla-Rios

“…Additionally, we linked this information with the structure of compounds previously isolated in the genus <i>Diaporthe</i>. …”
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Teleconnections detection of land use carbon emissions beyond geographical proximity promotes the construction of cross-city networks by Lei Shen, Yinghong Jiang, Duanqiang Zhai, Peng Wang

“…Then a complex network model is used to construct the spatial correlation strength, network structure, and network clustering among cities to identify spatial associations between cities within the YRDUA. …”
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Use of Relay Method for Enhancing Comb Construction by <i>Apis cerana cerana</i> Utilizing <i>Apis mellifera ligustica</i> by Shunhua Yang, Shanglun Ge, Yiqiu Liu, Danyin Zhou, Xueyang Gong, Kun Dong

“…Italian honey bees (IHBs, <i>Apis mellifera ligustica</i>) exhibit superior comb-building abilities compared with Chinese honey bees (CHBs, <i>Apis cerana cerana</i>), which often fail to fully utilize wax foundations, resulting in incomplete comb structures. The present study aimed to accelerate comb construction in CHB colonies using IHBs. …”
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