Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study by Heng‐Chung Kung, Jun Yu

“…Contributing to the poor prognosis of PDAC is the lack of early detection, a complex network of signaling pathways and molecular mechanisms, a dense and desmoplastic stroma, and an immunosuppressive tumor microenvironment. …”
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Neuronal Differentiation of Adipose Derived Stem Cells: Progress So Far by T. J. Moore, Heidi Abrahamse

“…Stem cell therapy using easily accessible mesenchymal stem cells, such as those found in the adipose stroma, has come to the fore in a number of biomedical disciplines as a potential therapeutic regime. …”
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Matrix metalloproteinase-3 is a potent prognostic factor associated with cell proliferation and migration in prostate cancer by Ai Sato, Kiyoshi Takagi, Mio Yamaguchi-Tanaka, Jotaro Okushima, Yuto Yamazaki, Akihiro Ito, Takashi Suzuki

“…Prostate cancer cells typically invade the surrounding stroma, and remodeling of the extracellular matrix (ECM) is a crucial step in the progress of prostate cancer. …”
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Effects of CO2 Enrichment on Growth and Development of Impatiens hawkeri by Fan-Fan Zhang, Yan-Li Wang, Zhi-Zhe Huang, Xiao-Chen Zhu, Feng-Jiao Zhang, Fa-Di Chen, Wei-Min Fang, Nian-Jun Teng

“…Furthermore, significant changes in chloroplast ultrastructure were observed at CO2 enrichment: an increased number of starch grains with an expanded size, and an increased ratio of stroma thylakoid to grana thylakoid. These results suggest that CO2 enrichment had positive effects on Impatiens, that is, it can improve the visual value, promote growth and development, and enhance antioxidant capacity.…”
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Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma by Levi van Hijfte, Marjolein Geurts, Iris de Heer, Santoesha A. Ghisai, Hayri E. Balcioglu, Youri Hoogstrate, Wies R. Vallentgoed, Rania Head, Rosa Luning, Thierry van den Bosch, Bart Westerman, Pieter Wesseling, Johanna A. Joyce, Pim French, Reno Debets

“…T cell cuffs are uniquely characterized by a high abundance of gemistocytic tumor cells (GTC) in the surrounding stroma. Integrative analysis shows that GTC-high tumors are enriched for lymphocytes and tumor associated macrophages (TAM) and express immune cell migration and activation programs. …”
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Cemento-Ossifying Fibroma in a Patient with End-Stage Renal Disease by Divya Gopinath, V. T. Beena, G. Sugirtharaj, K. Vidhyadharan, K. Salmanul Faris, Sajai J. Kumar

“…The histopathological examination revealed irregularly shaped bone and cementum-like hard tissue calcifications contained within hypercellular fibrous tissue stroma, leading to a confirmation of the diagnosis of cemento-ossifying fibroma. …”
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Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice by Kyvan Dang, Alka Singh, Xin Chen, Jennifer L. Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua J. Zhu, Y. Tony Ip, Xu Wu, Junhao Mao

“…We show that YAP is upregulated in the stroma during dextran sodium sulfate (DSS)-induced injury, and mesenchymal YAP activation facilitates intestinal epithelial regeneration. …”
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Epichloë scottii sp. nov., a new endophyte isolated from Melica uniflora is the missing ancestor of Epichloë disjuncta by Torsten Thünen, Yvonne Becker, Murray P. Cox, Samad Ashrafi

“…Abstract Here we describe a new, haploid and stroma forming species within the genus Epichloë, as Epichloë scottii sp. nov. …”
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A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens by Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, Irene Li, Asmita Bhattacharya, Yuanyuan Li, Winston Trope, Joseph B. Shrager, Calvin Kuo, Michael G. Ozawa, Amato J. Giaccia, Lu Tian, Sylvia K. Plevritis

“…Our data show that assembloids recapitulate human LUAD tumor-stroma spatial organization, justifying their use as a tool for investigating the spatial biology of human disease. …”
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The importance of multiple Z- plasty- assisted physical therapy in the treatment of Dupuytren’s contracture by Nader Gomaa Elmelegy, Dalia Nader

“…Results Histologically, all our specimens showed chronic inflammatory skin lesions showing hyperkeratotic epidermal covering and dermal infiltration with aggregates of chronic inflammatory cells, mainly lymphocytes and plasma cells, proliferated vascular spaces, and fibrous stroma. Clinical satisfaction was excellent in 67(88.2%) hands, good in six (7.8%)hands, fair in three (4%) hands, and no poor results. …”
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Bilateral Ovarian Serous Borderline Tumor with Non-Invasive Endometrial Implants by Melissa Bou Malham, Jordy Mehawej, Andreas Filippaios, Christina Kushnir, Paulette Mhawech-Fauceglia

“…The endometrium sections showed several small foci of SBT within the endometrial stroma, consistent with non-invasive implants of the endometrium. …”
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Extremely Rare Intraoral Presentation of Localized Amyloidosis by Luka Morelato, Igor Smojver, Sven Seiwerth, Dragana Gabrić

“…Histopathological assessments of the biopsy specimen showed that the stroma was occupied by a multiplied, partially hyalinized connective tissue. …”
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A morphometric signature to identify ductal carcinoma in situ with a low risk of progression by Marcelo Sobral-Leite, Simon P. Castillo, Shiva Vonk, Hendrik A. Messal, Xenia Melillo, Noomie Lam, Brandi de Bruijn, Yeman B. Hagos, Myrna van den Bos, Joyce Sanders, Mathilde Almekinders, Lindy L. Visser, Emma J. Groen, Petra Kristel, Caner Ercan, Leyla Azarang, Jacco van Rheenen, E. Shelley Hwang, Yinyin Yuan, Grand Challenge PRECISION Consortium, Renee Menezes, Esther H. Lips, Jelle Wesseling

“…A combined clinical-morphometric signature, characterized by small-sized ducts, a low number of cells and a low DCIS/stroma ratio, was associated with outcome (HR = 0.56; 95% CI 0.28–0.78). …”
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Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma by Yifei Cheng, Xiaofang Chen, Li Feng, Zhicheng Yang, Liyun Xiao, Bin Xiang, Xiaodong Wang, Dongbin Liu, Penghui Lin, Jieyi Shi, Guohe Song, Wulei Qian, Boan Zhang, Yanan Xu, Zheng Gao, Lv Chen, Yingcheng Wu, Jiaqiang Ma, Youpei Lin, Haichao Zhao, Lihua Peng, Xuebin Mao, Yang Liu, Hao Hou, Mingyu Yang, Yuan Ji, Xiaoying Wang, Jian Zhou, Xun Xu, Xiyang Liu, Wu Wei, Xiaoming Zhang, Qiang Gao, Hu Zhou, Yidi Sun, Kui Wu, Jia Fan

“…Collectively, our findings suggest stroma-targeted strategies for HCC based on defined stromal archetypes, raising the concept that CAFs change their transcriptional program and intercellular crosstalk according to the spatial context.…”
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Impaired Adipose Tissue Expandability and Lipogenic Capacities as Ones of the Main Causes of Metabolic Disorders by Isabel Moreno-Indias, Francisco José Tinahones

“…Nevertheless, why the adipose tissue reduces its capacity to make new adipocytes via mesenchymal cells of the stroma has not yet been elucidated. Thus, we suggest that this tissue ceases fulfilling its main function, the storage of excess fat, thereby affecting some of the key factors involved in lipogenesis, some of which are reviewed in this paper (PPARγ, ROR1, FASN, SCD1, Rab18, BrCa1, ZAG, and FABP4). …”
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Monostotic Fibrous Dysplasia of the Rib: A Case Report by Asha Mahadevappa, Sapna Patel, Sunila Ravishankar, Gubbanna V. Manjunath

“…Fibrous dysplasia is a noninherited bone disease in which abnormal differentiation of osteoblasts leads to replacement of normal marrow and cancellous bone by immature bone with fibrous stroma. Monostotic fibrous dysplasia accounts for 28% in the ribs. …”
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Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma by Stefanie Meyer, Thomas Vogt, Michael Landthaler, Anna Berand, Albrecht Reichle, Frauke Bataille, Andreas H. Marx, Anne Menz, Arndt Hartmann, Leoni A. Kunz-Schughart, Peter J. Wild

“…In metastatic MM, PPARG expression may be a predicitive marker for response to biomodulatory stroma-targeted therapy.…”
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Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…Also, the identification of the crosstalks in leukemia-stroma interaction within the tumor microenvironment may unveil new targetable mechanisms in disease relapse. …”
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Photochemical corneal cross-linking: Evaluating the potential of a hand-held biopen by Nadina Usseglio, Julia López de Andrés, Juan Antonio Marchal, Lorenzo Moroni, Daniel Nieto

“…Cytotoxicity, cell viability and immunofluorescence experiments were performed with human corneal stroma keratocytes (HCK) loaded inside the proposed bioink compositions. …”
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Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy by Veronica Tisato, Paolo Perri, Erika Rimondi, Elisabetta Melloni, Giuseppe Lamberti, Daniela Milani, Paola Secchiero, Giorgio Zauli

“…Photorefractive keratectomy (PRK) represents a therapeutic option to remodel corneal stroma and to compensate refractive errors, which involves inflammatory and/or regenerative processes. …”
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