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2921
Iron Chelation Therapy in Myelodysplastic Syndromes
Published 2010-01-01“…Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. …”
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2922
Genetic Associations in Acquired Immune-Mediated Bone Marrow Failure Syndromes: Insights in Aplastic Anemia and Chronic Idiopathic Neutropenia
Published 2012-01-01“…However, in immune-mediated bone marrow failure syndromes, such as acquired aplastic anemia and chronic idiopathic neutropenia, in which the pathophysiology results from a myelosuppressive bone marrow microenvironment mainly due to the presence of activated T lymphocytes, leading to the accelerated apoptotic death of the hematopoietic stem and progenitor cells, such genetic associations have been very limited. …”
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2923
Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury
Published 2023-01-01“…In our study, we systematically investigated the differentiation of neural stem cells (NSCs) in vitro and functional recovery in injured rats in vivo following Taxol treatment. …”
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2924
Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure
Published 2025-01-01“…Head regeneration in planaria is a remarkable phenomenon in which stem cells (neoblasts) migrate to the wound site, proliferate, then differentiate into all functional tissue types within days of injury. …”
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2925
Biologic Augmentation of the Ulnar Collateral Ligament in the Elbow of a Professional Baseball Pitcher
Published 2015-01-01“…A construct comprising a dermal allograft, platelet rich plasma (PRP), and mesenchymal stem cells (MSCs) has been shown to successfully improve healing in the rotator cuff. …”
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2926
E-cadherin/CD34 double immunostaining in placental diagnosis
Published 2024-09-01“…It also highlights the basement membranes of syncytiotrophoblastic cells which, in conjunction with endothelial staining, is helpful in the diagnosis of widening thereof in distal villous hypomaturity. …”
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2927
Diagnostic and Treatment Challenges of Paroxysmal Nocturnal Hemoglobinuria in Uganda
Published 2019-01-01“…Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare disorder of the hematopoietic stem cells which is often underdiagnosed. Its incidence is about 5 cases per million inhabitants in a year, and currently, there are only 1610 patients in the International PNH Registry. …”
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2928
Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway
Published 2025-02-01“…A. muciniphila was identified as a key strain in FMT to promote the proliferation and differentiation of intestinal stem cells by mediating the Wnt/β-catenin signaling pathway.…”
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2929
Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment
Published 2025-02-01“…Interestingly, this system is specifically oriented towards synovium-derived stem cells. The insight into trace element-driven, site-specific miRNA selectively loading in SMSC-EXOs proposes a promising therapeutic enhancement strategy for TMJOA.…”
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2930
Effect of Opioid on Adult Hippocampal Neurogenesis
Published 2016-01-01“…Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. …”
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2931
Plucked Human Hair Shafts and Biomolecular Medical Research
Published 2013-01-01“…The plucked hair shaft offers such advantages. The use of stem cells found in hair follicles cells is gaining momentum in the field of regenerative medicine. …”
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2932
Cannabigerol and cannabichromene in Cannabis sativa L.
Published 2021-09-01“…Cannabinoid CBC has also shown anti-inflammatory effects and reduced hypermobility in the gut and has displayed potential in vitro effect on adult neural stem progenitor cells. CBC also exerts modest analgesic properties in rodents, as well as anti-fungal, anti-bacterial, pro-apoptotic, and anti-proliferative effects in tumor cells.…”
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2933
Cissus quadrangularis: A comprehensive review as an emerging biomaterial for periodontal regeneration
Published 2025-01-01“…CQ can differentiate human-derived mesenchymal stem cells into osteoblast and regenerate bone. This review elaborates on the use of CQ as a bioactive compound for periodontal regeneration.…”
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2934
ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation
Published 2025-02-01“…However, its role across different cancer types is not well understood.MethodsUtilizing multi-omics data, we comprehensively evaluated ITGA4’s expression, clinical relevance, diagnostic and prognostic value, functions, mutations, and methylation status, along with its impact on immunity, mismatch repair (MMR), heterogeneity, stemness, immunotherapy responsiveness, and drug resistance in pan-cancer, with partial validation in gastric cancer (GC) using transcriptomic analysis, single-cell data, western blot (WB), wound-healing assay, flow cytometry and immunohistochemistry (IHC). …”
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2935
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2936
Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation
Published 2025-01-01“…Finally, the anti-leukemia effect of cynaroside was further confirmed through in vivo experimental validation.ResultsFirstly, the flavonoid content of stem, leaves, flesh, and peel from 13 sweet potato cultivars was examined. …”
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2937
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2938
Biomarkers as Key Contributors in Treating Malignant Melanoma Metastases
Published 2012-01-01“…At the present time, at least three hypotheses were identified that may explain melanoma aetiology, as follows: (1) a model of linear progression from differentiated melanocytes to metastatic cancer cells (2) a model involving the appearance of melanoma stem-like cells, and (3) an epigenetic progenitor model of cancer. …”
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2939
Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications
Published 2013-01-01“…In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. …”
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2940
Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus
Published 2021-01-01“…Recent developments in the field of tissue engineering have led to a renewed interest in novel biomaterial alternatives such as stem cells. This might be attributable to their differentiation potential towards hepatic and pancreatic lineage. …”
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