NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

“…Methods Induced pluripotent stem cell (iPSC)-derived mDANs from PD patients with a monoallelic SNCA locus duplication and unaffected controls were treated with NPT100-18A. αSyn aggregation was evaluated biochemically and reactive oxygen species (ROS) levels were assessed in living mDANs using fluorescent dyes. …”
Get full text

Angiogenesis and Its Therapeutic Opportunities by So Young Yoo, Sang Mo Kwon

Get full text

Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer by Mladen Pavlovic, Nevena Gajovic, Milena Jurisevic, Slobodanka Mitrovic, Gordana Radosavljevic, Jelena Pantic, Nebojsa Arsenijevic, Ivan Jovanovic

Get full text

Diagnostic Role of Chromosomal Instability in Melanoma by Nitika Dabas, Diana M. Byrnes, Ashley M. Rosa, Mark S. Eller, James M. Grichnik

Get full text

Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions by Chen-Yu Zou, Chen Han, Fei Xing, Yan-Lin Jiang, Ming Xiong, Jesse Li-Ling, Hui-Qi Xie

Get full text

Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

Get full text

Comparable outcomes after busulfan- or treosulfan-based conditioning for allo-HSCT in children with ALL: results of FORUM by Krzysztof Kalwak, Laura M. Moser, Ulrike Pötschger, Peter Bader, Katharina Kleinschmidt, Roland Meisel, Jean-Hugues Dalle, Akif Yesilipek, Adriana Balduzzi, Gergely Krivan, Evgenios Goussetis, Raquel Staciuk, Petr Sedlacek, Herbert Pichler, Peter Svec, Melissa Gabriel, Tayfun Güngör, Ernest Bilic, Jochen Buechner, Marleen Renard, Kim Vettenranta, Marianne Ifversen, Cristina Diaz-de-Heredia, Jerry Stein, Jacek Toporski, Marc Bierings, Christina Peters, Marc Ansari, Franco Locatelli

“…Abstract: The superiority of total body irradiation (TBI)–based vs chemotherapy conditioning for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukemia (ALL) has been established in the international, prospective phase-3 FORUM study, randomizing 417 patients aged 4-18 years in complete remission (CR), who received allo-HSCT from HLA-matched sibling or unrelated donors. …”
Get full text

Predicting cytomegalovirus infection and graft-versus-host disease using QuantiFERON-CMV and Monitor in pediatric transplants: a proof-of-concept study by Lina Souan, Rawad Rihani, Maher A. Sughayer

“…Background: Cytomegalovirus (CMV) infection can lead to significant morbidity and mortality in pediatric hematopoietic stem cell transplant recipients. Early detection of CMV infection is crucial for managing its impact. …”
Get full text

Diphencyprone Induced Vitiligo: A Case Report by Mohammad Ali Nilforoushzadeh, Gelavizh Keshtmand, Fariba Jaffary, Abbas Kheirkhah

Get full text

Influence of MHC on genetic diversity and testicular expression of linked olfactory receptor genes by Mingue Kang, Byeongyong Ahn, Jae Yeol Shin, Hye-Sun Cho, Jongan Lee, Chankyu Park

Get full text

Chemical catalyst manipulating cancer epigenome and transcription by Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo R. Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, Atsushi Kaneda, Shigehiro A. Kawashima, Motomu Kanai

Get full text

Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis by Alireza Lorzadeh, George Ye, Sweta Sharma, Unmesh Jadhav

Get full text

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

Get full text

Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury by Ping Li, Zhao-Qian Teng, Chang-Mei Liu

Get full text

Histocompatibility and Hematopoietic Transplantation in the Zebrafish by Jill L. O. de Jong, Leonard I. Zon

“…Hematopoietic stem cells (HSCs) are the source of all the blood cells needed by an organism during its lifetime. …”
Get full text

IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection by Robert B. Ashman, Dipti Vijayan, Christine A. Wells

Get full text

Cost-reduction strategy to culture patient derived bladder tumor organoids by Mahsa Mollapour Sisakht, Fatemeh Gholizadeh, Shirin Hekmatirad, Tokameh Mahmoudi, Saeed Montazeri, Laleh Sharifi, Hamed Daemi, Shahla Romal, Mohammad Hosein Yazdi, Mohammad Ali Faramarzi, Ahmad Reza Shahverdi, Amir Ali Hamidieh

“…Abstract Organoids as self-organized structure derived from stem cells can recapitulate the function of an organ in miniature form which have developed great potential for clinical translation, drug screening and personalized medicine. …”
Get full text

Expression Profiling and Functional Implications of a Set of Zinc Finger Proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in Primary Osteoarthritic Articular Chondrocytes by Maria Mesuraca, Olimpio Galasso, Leonardo Guido, Emanuela Chiarella, Stefania Scicchitano, Renaud Vatrinet, Giovanni Morrone, Heather M. Bond, Giorgio Gasparini

Get full text

HP1 Promotes the Centromeric Localization of ATRX and Protects Cohesion by Interfering Wapl Activity in Mitosis by Erchen Zhang, Lei Peng, Kejia Yuan, Zexian Ding, Qi Yi

Get full text

Frequency and Prognostic Relevance of FLT3 Mutations in Saudi Acute Myeloid Leukemia Patients by Ghaleb Elyamany, Mohammad Awad, Kamal Fadalla, Mohamed Albalawi, Mohammad Al Shahrani, Abdulaziz Al Abdulaaly

“…The Fms-like tyrosine kinase-3 (FLT3) is a receptor tyrosine kinase that plays a key role in cell survival, proliferation, and differentiation of hematopoietic stem cells. …”
Get full text