The Interplay between the Bone and the Immune System by Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, Giacomina Brunetti

“…On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. …”
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Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy by Vianey Q. Casarez, Acsa M. Zavala, Pascal Owusu-Agyemang, Katherine Hagan

“…She had multiple anesthetics while undergoing allogeneic hematopoietic stem cell transplantation. This case report will discuss the successful repeated use of the same anesthetic in this pediatric patient, with the avoidance of volatile anesthetic agents, propofol, and muscle relaxant.…”
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Laboratory Diagnosis of Invasive Aspergillosis: From Diagnosis to Prediction of Outcome by Richard C. Barton

“…Invasive aspergillosis (IA), an infection caused by fungi in the genus Aspergillus, is seen in patients with immunological deficits, particularly acute leukaemia and stem cell transplantation, and has been associated with high rates of mortality in previous years. …”
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Spontaneous high clonal expansion of Wilms’ tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms’ tumor gene 1-expressing solid tumor by Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoya Hashimoto, Toshiki Yoshimine, Atsushi Kumanogoh, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

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Intra-mesenteric steroids for steroid-refractory graft-versus-host disease in pediatric patients: A safe option by Ana M. Aristizábal, Lina P. Montaña, Jaiber Gutiérrez, Diego Medina, Alexis A. Franco, Eliana Manzi, Ángela Devia Zapata, Walter Mosquera

“…Graft-versus-host disease is a serious complication after hematopoietic stem cell transplantation and is a major cause of death post-transplantation. …”
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A synthetic biological secondary metabolite, Lycogenâ¢, produced and extracted from Rhodobacter sphaeroides WL-APD911 in an optimizatioal scale-up strategy by Cheng-Chin Wang, Shi-Ying Huang, Shu-Hung Huang, Zhi-Hong Wen, Jyun-Ying Huang, Wen-Sheng Liu, Hui-Min David Wang

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Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies by Lisa M. Billesberger, Kyle M. Fisher, Yawar J. Qadri, Richard L. Boortz-Marx

“…Small studies have examined prolotherapy and stem cell therapy and demonstrate some benefits. Trials involving genicular nerve block procedures have been successful. …”
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The Interplay Between Viral Infection and Cell Death: A Ping-Pong Effect by Alireza Nourazarian, Hadi Yousefi, Cigir Biray Avci, Behrouz Shademan, Emad Behboudi

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Estimating the Burden of Cost in Chronic Graft-versus-Host Disease: A Human Capital Approach by Chris A. Jones, Luca P. Fernandez, Peter Weimersheimer, Neil A. Zakai, Michael Sharf, Oscar A. Mesa, Christian Peters, Antonio di Carlo, Mitchell C. Norotsky

“…With advances in organ matching and preventing acute graft-versus-host-disease (aGvHD), chronic graft-versus-host disease (cGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) has become a focus of transplant-related morbidity and mortality. …”
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Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…This study analysed the secretomes of bone-marrow (BM.MSCs), umbilical-cord (UC.MSCs), adipose-tissue (AT.MSCs) and clinical/commercial-grade induced pluripotent stem cell-derived MSCs (iMSCs), under resting and inflammatory licenced conditions. iMSCs recapitulated the inflammatory licensing process, validating their comparability to tissue-derived MSCs. …”
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Secondary Primary Malignancies in Multiple Myeloma: An Old Nemesis Revisited by Jay Yang, Howard R. Terebelo, Jeffrey A. Zonder

“…High-dose chemotherapy with autologous stem cell support became widely accepted for myeloma in the 1990s. …”
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Septic Shock Induced by Bacterial Prostatitis with Morganella morganii subsp. morganii in a Posttransplantation Patient by Xiaofan Li, Jianhui Chen

“…Bacterial infection is a common complication after Hematopoietic Stem Cell Transplantation (HSCT). Morganella morganii is ubiquitous Gram-negative facultative anaerobe, which may cause many kinds of opportunistic infection. …”
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Treatment of Acute Graft-versus-Host Disease in Liver Transplant Recipients by Edward Kim, Alina Adeel, Adel Bozorgzadeh, Shinya Amano, Curtis T. Barry, Jennifer S. Daly, Deepika Devuni, Zendee Elaba, Laura Houk, Paulo N. Martins, Babak Movahedi, Muthalagu Ramanathan, Nicole M. Theodoropoulos

“…We report on two patients who developed aGvHD after liver transplantation who were treated with ruxolitinib, a novel Janus kinase 1/2 (JAK) inhibitor that has been shown to improve outcomes in steroid refractory cases of aGvHD after allogenic hematopoietic stem cell transplantation. We reviewed the literature to discuss various therapeutic options currently available for aGvHD after liver transplantation.…”
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Mechanism and Treatment Strategy of Osteoporosis after Transplantation by Lei Song, Xu-Biao Xie, Long-Kai Peng, Shao-Jie Yu, Ya-Ting Peng

“…Using the signaling pathway or implantation bone marrow stem cell provides a novel direction for the treatment of OP, especially OP after transplantation. …”
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Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches by Yang-Jin Shen, Yin-Cheng Huang, Yi-Chuan Cheng

“…This review provides a comprehensive and critical evaluation of recent advancements in antioxidant-based therapeutic strategies for SCI, including natural compounds, RNA-based therapies, stem cell interventions, and biomaterial applications. …”
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Is PPAR𝛾 a Prospective Player in HIV-1-Associated Bone Disease? by Eoin J. Cotter, Patrick W. Mallon, Peter P. Doran

“…Interestingly, both adipocytes and osteoblasts are derived from a common precursor cell type; the mesenchymal stem cell. The possibility that dysregulation of PPAR𝛾 (and the subsequent effect on both osteoblastogenesis and adipogenesis) is a contributory factor in the lipid- and bone-abnormalities observed in HIV-1 infection and treatment has also been investigated. …”
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Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS).…”
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Regeneration of Zebrafish CNS: Adult Neurogenesis by Sukla Ghosh, Subhra Prakash Hui

“…Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming.…”
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Pyruvate Kinase Deficiency Causing Priapism by Vinay Hanyalu Shankar, Bharadwaj Adithya-Sateesh, Nicole Gousy, Girma Ayele, Freyr Petursson, Rediet Atalay, Miriam Michael

“…Management strategies vary from full splenectomies to hematopoietic stem cell transplants with gene therapies with transfusions and administration of PK-activators coming in between. …”
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Paroxysmal Nocturnal Hemoglobinuria: Diagnostic Challenges in Pediatric Patient by Dharshana Krishnaprasadh, Inna Kaminecki, Anna Sechser Perl, Jonathan Teitelbaum

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematologic stem cell disorder characterized by hemoglobinuria, thrombosis, and tendency for bone marrow failure. …”
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