Sustained slow-release TGF-β3 in a three-dimensional-printed titanium microporous scaffold composite system promotes ligament-to-bone healing by Liwei Zhu, Yuzhe Liu, Yifu Sun, Zhenjia Che, Youbin Li, Tengyue Liu, Xudong Li, Chengzhe Yang, Lanfeng Huang

“…In vitro, the composite system exhibited good biocompatibility and was beneficial for the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs), which showed high growth activity. …”
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Influence of advanced maternal age and gestational age on the morphology of human placenta by Jovičić Sanja, Ljubojević Vesna, Barudžija Maja, Amidžić Ljiljana, Škrbić Ranko, Nikolić Ivan R.

“…Due to its availability and high content of stem cells and growth factors, placenta tissue has found its application in regenerative medicine. …”
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Fluoroscopy Assisted Minimally Invasive Transplantation of Allogenic Mesenchymal Stromal Cells Embedded in HyStem Reduces the Progression of Nucleus Pulposus Degeneration in the Da... by Rifa Aquidah Subhan, Karunanithi Puvanan, Malliga Raman Murali, Hanumantha Rao Balaji Raghavendran, Samuel Shani, Basri Johan Jeet Abdullah, Azlina Amir Abbas, Jamal Azmi Mohamed, Tunku Kamarul

“…This study was conducted to develop a technique for minimally invasive and accurate delivery of stem cells to augment nucleus pulposus (NP) in damaged intervertebral discs (IVD). …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…The authors investigated the effects of psychotropics on pathobiological proteins, proteasomal activity, mitochondrial functions, apoptosis, neuroinflammation, trophic factors, stem cells, and neurogenesis. Only findings replicated in at least 2 studies were considered for these actions. …”
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Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis by B. I. Yalaev, R. I. Khusainova

“…These interactions have been determined to be associated with the control of expression of a number of transcription factors and the differentiation of mesenchymal stem cells through the pathway of osteoblastogenesis or adipogenesis, and monocytic precursors through the pathway of osteoclastogenesis. …”
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How to Deal with Pulpitis: An Overview of New Approaches by Jakub Fiegler-Rudol, Wojciech Niemczyk, Katarzyna Janik, Anna Zawilska, Małgorzata Kępa, Marta Tanasiewicz

“…These methods utilize stem cells, growth factors, and biomaterials to regenerate vascularized, functional pulp tissue. …”
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Potential Pitfalls of the Humanized Mice in Modeling Sepsis by Krzysztof Laudanski, Michael Stentz, Matthew DiMeglio, William Furey, Toby Steinberg, Arpit Patel

“…Often, grafting is performed utilizing an identical batch of stem cells in highly inbred animals which fails to account for human heterogeneity. …”
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Data and implication based comparison of two chronic myeloid leukemia models by R. A. Everett, Y. Zhao, K. B. Flores, Yang Kuang

“…Chronic myeloid leukemia, a disorder of hematopoietic stem cells, is currently treated using targeted molecular therapy with imatinib. …”
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Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model by Atsushi Mima, Azuma Kimura, Ryo Ito, Yu Hatano, Hiraku Tsujimoto, Shin-Ichi Mae, Junko Yamane, Wataru Fujibuchi, Norimitsu Uza, Taro Toyoda, Hiroshi Seno, Kenji Osafune

“…Pancreatic acinar cells differentiated from human induced pluripotent stem cells (hiPSCs) have the potential to solve this issue. …”
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Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy by Hui-ying Zhang, Qiu-yang Zhang, Qing Liu, Si-guo Feng, Yan Ma, Feng-sheng Wang, Yue Zhu, Jin Yao, Biao Yan

“…To improve delivery, we successfully loaded miR-205 into exosomes derived from mesenchymal stem cells. This innovative approach avoids cytotoxicity while preserving therapeutic efficacy in both cellular and animal models. …”
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The Notch Pathway in Breast Cancer Progression by Emmanuel N. Kontomanolis, Sofia Kalagasidou, Stamatia Pouliliou, Xanthoula Anthoulaki, Nikolaos Georgiou, Valentinos Papamanolis, Zacharias N. Fasoulakis

“…The cross-talk of Notch and estrogens, the effect of Notch in breast cancer stem cells formation, and the dependable Notch overexpression during breast tumorigenesis have been studied enough and undoubtedly linked to breast cancer development. …”
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Combined BPA and DIBP Exposure Induced Intestinal Mucosal Barrier Impairment Through the Notch Pathway and Gut Microbiota Dysbiosis in Mice by Mengge Duan, Yuting Wang, Shiyu Chen, Jiawen Lu, Ruihong Dong, Qiang Yu, Jianhua Xie, Yi Chen

“…The results indicated that the combination of BPA and DIBP exposure resulted in a reduction of beneficial flora, an increase in D-Lac levels (136 ± 14 μmol/L), an increase in intestinal permeability, activation of the notch pathway, and a decline in intestinal stem cells (ISCs) to goblet cells, compared to single-exposure sources. …”
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Advances in cardiac organoid research: implications for cardiovascular disease treatment by Ziteng Huang, Keran Jia, Yadan Tan, Yang Yu, Wudian Xiao, Xiangyu Zhou, Jingyan Yi, Chunxiang Zhang

“…Cardiac organoids, which are three-dimensional structures derived from the induced differentiation of stem cells, are particularly promising. These organoids not only replicate the autonomous beating and essential electrophysiological properties of the heart but are also widely employed in studies related to cardiac diseases, drug efficacy testing, and regenerative medicine. …”
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Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway by Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng

“…It promoted chondrogenic differentiation of mesenchymal stem cells, inhibited angiogenesis, enhanced PHD2 expression, and suppressed the production of HIF-1α and VEGFA. …”
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Postcare for Repairing Nerve and Tendon Injury Based on Biomimetic Nano-Parallel Material Composite Protein by Junxia Fu, Xiaohong Tan, Yan Tang

“…The purpose of this study is to study the use of biomimetic nano-parallel material composite proteins to induce the directional differentiation of stem cells to tendon lineages to promote muscle regeneration and repair. …”
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MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway. by Jiafei Yang, Tianjiu Zhang, Xingtao Zhu, Zhexi He, Xu Jiang, Song Yu, Huajian Gu

“…This study investigates the role of miRNA-223-5p in regulating hypoxia-induced apoptosis and enhancing osteogenesis in bone marrow mesenchymal stem cells (BMSCs). Utilizing a juvenile New Zealand white rabbit model of LCPD established through femoral neck ligation, we transfected BMSCs with miR-223-5p mimics, inhibitors, and controls, followed by hypoxic exposure. …”
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Effects of Pentoxifylline in a Rat Model of Manganism: Evaluation of the Possible Toxicity by Romina Tanideh, Omid Farshad, Akram Jamshidzadeh, Aida Iraji

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First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood by A. Jensen, E. Hamelmann

“…Therefore, based on experimental evidence, we explored the therapeutic potential of human cord blood, known to contain stem cells, to examine the functional neuroregeneration in a child with cerebral palsy after cardiac arrest. …”
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A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation by R. N. Mustafin

“…The hypothesis is confirmed by research into transposon activation in neuronal stem cells during neuronal differentiation. These changes occur in the hippocampus dentate gyrus, where a pronounced activity of transposons and their insertion near neuron-specific genes have been detected. …”
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Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review by Aref Yarahmadi, Hamed Afkhami, Ali Javadi, Mojtaba Kashfi

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