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2701
Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer
Published 2025-01-01“…It is especially attractive given its selective expression on the surface of solid tumor cells and associated stromal cells, such as cancer stem cells, invasive cancer cells, and immune cells, such as macrophages, angiogenic endothelial cells, pericytes, and cancer-associated fibroblasts. …”
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2702
Deficiency of ACE2 in Bone-Marrow-Derived Cells Increases Expression of TNF-α in Adipose Stromal Cells and Augments Glucose Intolerance in Obese C57BL/6 Mice
Published 2012-01-01“…We evaluated effects of ACE2 deficiency in bone-marrow-derived stem cells on adipose inflammation and glucose tolerance in C57BL/6 mice fed a high fat (HF) diet. …”
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2703
Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome
Published 2019-03-01“…A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.…”
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2704
Wound Healing Using Electrical Stimulation: A Review
Published 2023-12-01“…The healing of wounds is always attributed to the ability of the affected skin to produce an electric current that helps the migration of stem cells and platelets to the place of extraction For the sake of healing, this is why electrical stimulation ES devices played an important role in the process of stimulation and wound treatment through using the high voltage pulsed current HVPC, low voltage pulsed current LVPC, direct current DC or pulse current PC. …”
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2705
In situ-formed cryomicroneedles for intradermal cell delivery
Published 2024-02-01“…As a proof-of-concept, we examined the loading and intradermal delivery of three cell types in clinically relevant in vitro and in vivo models, including mesenchymal stem cells for wound healing, melanocytes for vitiligo treatment, and antigen-pulsed dendritic cells for cancer vaccination.…”
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2706
Cellular and Molecular Changes in Orthodontic Tooth Movement
Published 2011-01-01“…Besides, the involvement of stem cells and their development towards osteoblasts and osteoclasts during orthodontic treatment have also been explained. …”
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2707
The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?
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2708
Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration
Published 2021-01-01“…We injected autologous mesenchymal stem cells obtained from the bone marrow and adipose tissue and platelet-rich plasma into the joint of the patient at the area of injury, as well as intravenously. …”
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2709
Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus
Published 2021-01-01“…Recent developments in the field of tissue engineering have led to a renewed interest in novel biomaterial alternatives such as stem cells. This might be attributable to their differentiation potential towards hepatic and pancreatic lineage. …”
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2710
Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases
Published 2023-01-01“…They can also increase or reduce neuronal damage by regulating the body’s signaling pathways, immune system, stem cells, gut microbiota, etc. They can not only affect the occurrence of diseases and exacerbate disease progression but also promote neuronal repair and reduce apoptosis, to prevent and slow down the development of diseases. …”
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2711
Hypothesis: glyphosate-based herbicides can increase risk of hematopoietic malignancies through extended persistence in bone
Published 2025-01-01“…A novel two-part hypothesis is explored: first, the likely reason for the lack of variability in GLY levels in urine is that GLY stored in bone is excreted gradually over days to weeks, and augments the generally stable and modest levels of dietary exposure to GLY; and second, the prolonged systemic movement of GLY into bone marrow and bone extends contact between GLY and hematopoietic stem cells (HSC), increasing the risk of GLY-induced breaks and rearrangements in the DNA in HSCs. …”
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2712
Cissus quadrangularis: A comprehensive review as an emerging biomaterial for periodontal regeneration
Published 2025-01-01“…CQ can differentiate human-derived mesenchymal stem cells into osteoblast and regenerate bone. This review elaborates on the use of CQ as a bioactive compound for periodontal regeneration.…”
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2713
A mathematical model of mechanotransduction
Published 2023-03-01“…Potential applications are discussed, such as predicting growth and remodeling in the diseased heart, analyzing stretch-induced arrhythmias, modeling shear forces in a vessel caused by blood flow, examining the role of mechanical forces in engineered sheets of tissue, studying differentiation in colonies of stem cells, and characterizing the response to localized forces applied to nanoparticles.…”
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2714
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2715
Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa‐Ephb2 Pair
Published 2025-01-01“…Here, plant‐derived compounds are screened for in vitro activity upon ovarian organoids derived from feeder‐free female germline stem cells. Tetrahydroxy stilbene glucoside (TSG) is found to promote the development of ovarian organoids. …”
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2716
Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
Published 2025-01-01“…Furthermore, we identified nuclear REST loss and the neuroblast marker, DCX, was downregulated in DS human trisomic induced pluripotent stem cells (hiPSCs)-derived NPCs, whereas the glioblast marker, NFIA, was upregulated. …”
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2717
Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance
Published 2021-01-01“…Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell-to-cell interactions through soluble factors to maintain normal placental development. …”
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2718
Phospho-seq: integrated, multi-modal profiling of intracellular protein dynamics in single cells
Published 2025-02-01“…We apply our workflow to cell lines, induced pluripotent stem cells, and months-old retinal and brain organoids to demonstrate its broad applicability. …”
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2719
miR-142 deficit in T cells during blast crisis promotes chronic myeloid leukemia immune escape
Published 2025-02-01“…Abstract We reported that an acquired miR-142 deficit transforms chronic phase (CP) chronic myeloid leukemia (CML) leukemic stem cells (LSCs) into blast crisis (BC) LSCs. Given the role of miR-142 in the development and activity of the immune system, we postulated that this deficit also promotes LSC immune escape. …”
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2720
Pediatric Granular Cell Tumor of the Breast: A Case Report and Review of the Literature
Published 2015-01-01“…Granular cell tumors arise from neurogenic mesenchymal stem cells and can occur anywhere throughout the body. …”
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