Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Safety and tolerability measures comprised adverse events, vital signs, electrocardiography, laboratory tests, physical measurements, and extrapyramidal symptoms with the Simpsons-Angus Scale. Statistical analysis will include chi-square tests with Monte Carlo simulation for categorical variables, paired t tests or Wilcoxon tests for continuous variables, and multivariate linear mixed models to evaluate the primary outcome, adjusting for confounders. …”
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FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression by GAO Yuan, HUANG Yulan, ZHAO Kun

“…Significant increases were found in the mRNA levels of IL-1β, IL-6 and TNF-α of the macrophages with FDFT1 interference than the control cells (P<0.05). There were no statistical differences in the proliferation, apoptosis and migration of MC38 cells in the control group (OE-NC and sh-NC) and the cells of the FDFT1 overexpression group and FDFT1 knockdown group (P>0.05). …”
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Subtyping Social Determinants of Health in the "All of Us" Program: Network Analysis and Visualization Study by Suresh K Bhavnani, Weibin Zhang, Daniel Bao, Mukaila Raji, Veronica Ajewole, Rodney Hunter, Yong-Fang Kuo, Susanne Schmidt, Monique R Pappadis, Elise Smith, Alex Bokov, Timothy Reistetter, Shyam Visweswaran, Brian Downer

“…ConclusionsThis study identified SDoH subtypes that had statistically significant biclusteredness and replicability, each of which had significant associations with specific adverse health outcomes and with translational implications for targeted SDoH interventions and health care policies. …”
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Effect of multispecies swards on ruminal fermentation, methane emission and potential for climate care cattle farming − an in vitro study by M.U. Hassan, P. Sidoruk, D. Lechniak, M. Szumacher-Strabel, J. Bocianowski, S. Ślusarczyk, P.R. Hargreaves, D. Ruska, A. Dorbe, Dz. Kreismane, K. Klumpp, J. Bloor, R.M. Rees, A. Kuipers, P. Galama, Z. Váradyová, K. Čobanová, A. Cieślak

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Lactational performance effects of 3-nitrooxypropanol supplementation to dairy cows: A meta-regression by L.F. Martins, M. Maigaard, M. Johansen, P. Lund, X. Ma, M. Niu, A.N. Hristov

“…Treatment and control mean differences (MD) as well as standardized MD were calculated and used for data presentation and statistical analysis, respectively. Dose (± SD; 77.0 ± 33.17 mg 3-NOP/kg DMI), forage-to-concentrate ratio (FC; 58.9 ± 8.83%, expressed as average ± SD% of forage in the diet), dietary concentrations of CP, ether extract, NDF, and starch (16.3 ± 1.84%, 4.3 ± 1.03%, 33.7 ± 4.40%, and 20.9 ± 3.97%, as average ± SD% of DM, respectively), supplementation length (days), and DIM and BW of the cows at the beginning of the study were used as continuous explanatory variables. …”
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Perbedaan Sensitivitas Kuman Pseudomonas Aeruginosa Penyebab Infeksi Nosokomial Terhadap Beberapa Antibiotika Generik dan Paten by Ayu Andrian Putri, Roslaili Rasyid, Rahmatini .

“…From the results founded that generic and branded name of amoxicillin and erythromycin did not have results of germ-free zone, the germ-free zone of 3 sample that tested with generic kloramfenikol is bigger than the branded name and the less are the other way and the germ-free zone of 8 sample that tested with generic siprofloksasin is bigger than the branded name and the less are the other way.After doing statistical analysis using SPSS through the independent T-test showed that there was no significant difference between the sensitivity of Pseudomonas aeruginosa causes of nosocomial infections between generic and branded name of chloramphenicol and ciprofloxacin. …”
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Characterization of cellular immune system at different ages in water buffalo (Bubalus bubalis) by Maria C. Scata’, Giovanna De Matteis, Francesco Grandoni, Gabriele Di Vuolo, Giovanna Cappelli, Domenico Vecchio

“…Furthermore, the Kruskall-Wallis test highlighted statistical differences in the adult group between the farms in the mean value of percentage of granulocytes (p=0.0030), PBMC (p=0.0120), total (p=0.0152), helper (p=0.0047), cytotoxic (p=0.0019) and γδ T lymphocytes (p=0.0013); total monocytes (p=0.0100), cM and ncM subsets (p=0.0320; p=0.0252); CD21+ B lymphocytes (p=0.0007). …”
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In-vitro comparative thermo-chemical aging and penetration analyses of bioactive glass-based dental resin infiltrates by Syed Zubairuddin Ahmed, Abdul Samad Khan, Maram Alshehri, Fatimah Alsebaa, Fadak Almutawah, Moayad Mohammed Aljeshi, Asma Tufail Shah, Budi Aslinie Md Sabri, Sultan Akhtar, Mohamed Ibrahim Abu Hassan

“…Thermocycling (5,000 cycles) and chemical aging (4 weeks) were conducted, followed by microhardness, surface roughness, and SEM analyses. Statistical analyses were conducted after each test. …”
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Preoperative ultrasound risk factors for peripartum hysterectomy among PAS suspected pregnancies by Lulu Wang, Tianjiao Liu, Yang Yang, Yalan Li, Li Xiao, Xin Li, Sumei Wei

“…Multivariate logistic regression analysis was performed on the characteristics with statistical significance to explore risk factors for peripartum hysterectomy. …”
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Learning with Digital Tools vs. Learning Through Digital Tools in Physical Education: Impacts on Student Perceptions by André Klostermann, Till Etterlin

“…However, this interaction was statistically not significant, F(2, 62) = 1.51, p = .23, ηp² = 0.05. …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…The difference of MoCA total score (p=0.006), language (p=0.0026) and executive function (p=0.0004) scores between the groups was statistically significant. 40% of PD patients and 10% of controls were diagnosed with mild cognitive impairment (p=0.015). 30% of PD patients and 10% of control subjects scored 7 points or above in HAD anxiety subscale (p=0.021). …”
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Optimization of Dual-energy Spectral Lower-extremity Computed Tomography Venography Scanning Protocol: Phantom Study by Shigeng WANG, Renwang PU, Yijun LIU, Xin FANG, Wei WEI, Beibei LI

“…The imaging parameters for Group A were as follows: tube voltage of 120 kVp, auto tube-current technology (100~600 mA), noise index (NI) of 10, and image reconstruction using 40% posterior multimodel adaptive statistical iterative reconstruction (ASIR-V). The imaging parameters for Group B were spectral imaging (GSI) mode, instantaneous dual tube voltage of 80/140 kVp, tube current with GSI Assist technology, and three scan groups based on NI values of 10, 11, and 12. …”
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The success of reforestation after experimental strip-shelterwood felling in the pine stands of the Eastern Polissia of Ukraine by Anatolyi Zhezhkun

“…During the accounting by the selective statistical method, individuals of natural regeneration of tree species were divided into self-sowing: 1 and 2 years old, advance growth: 3 years old, 4-8 years old, 9-15 years old. …”
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Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…Data were recorded using MS Excel and analysed using Statistical Package for Social Sciences (SPSS version 22.0) software. …”
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Hubungan Lingkar Abdomen (Lingkar Perut) dengan Tekanan Darah by Marini Khairana Sari, Nur Indrawati Lipoeto, Rahmatina B. Herman

“…Research show</em><em>ed</em><em> </em><em> 14.13% of employees have high blood pressure (hypertension). The statistical test showed a significant correlation exists between abdominal circumference and systolic blood pressure in male and female subjects (p &lt;0.01 and p &lt;0.05), but there was no correlation between abdominal circumference and diastolic blood pressure both in the group of male and female subjects (p&gt; 0.05). …”
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Convolutional neural networks for sea surface data assimilation in operational ocean models: test case in the Gulf of Mexico by O. Zavala-Romero, O. Zavala-Romero, A. Bozec, E. P. Chassignet, J. R. Miranda, J. R. Miranda

“…The CNNs are trained to correct model errors from a 2-year, high-resolution (<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><mn mathvariant="normal">1</mn><mo>/</mo><mn mathvariant="normal">25</mn><mi mathvariant="italic">°</mi></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="31pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="0fa693bbf5c78df25ed18818c53372c4"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="os-21-113-2025-ie00001.svg" width="31pt" height="14pt" src="os-21-113-2025-ie00001.png"/></svg:svg></span></span>) HYCOM dataset, assimilated using the Tendral Statistical Interpolation System (T-SIS). The CNNs are trained to replicate the increments generated by the T-SIS data assimilation package, aiming to correct model forecasts of sea surface temperature (SST) and sea surface height (SSH). …”
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Predictors of recurrence of ventricular tachycardia and the effectiveness of endocardial ablation at the patients with sudden cardiac death and history of myocardial infarction by O. M. Grytsay, Ya. V. Skybchyk

“…At 12 months after the procedure, the following parameters were associated with relapses of ventricular tachycardia with the greatest statistical significance: left ventricular systolic dysfunction (additive relative risk (ARR) – 43.0 %, relative risk (RR) – 2.57 [1.14–5.82], odds ratio (OR) – 6.50 [7.00–30.70], p < 0.05), arterial hypertension (ARR – 41.0 %, RR – 2.75 [1.08–6.90], OR – 5.96 [1.33–26.70], p < 0.05), diabetes mellitus (ARR – 43.0 %, RR – 2.83 [1.10–7.30], OR – 6.50 [1.25–33.60], p < 0.05), duration of arrhythmic history (ARR – 40.0 %, OR – 5.71 [7.00–28.10], p < 0.05), electrical storm episode at the time of ablation (ARR – 38.0 %, RR – 1.89 [1.27–4.99], OR – 8.57 [7.00–51.50], p < 0.05). …”
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Magnetocaloric Effect for a <i>Q</i>-Clock-Type System by Michel Aguilera, Sergio Pino-Alarcón, Francisco J. Peña, Eugenio E. Vogel, Natalia Cortés, Patricio Vargas

“…Given the broader relevance of the <i>Q</i>-state clock model in areas such as percolation theory, neural networks, and biological systems, where multi-state interactions are essential, our study provides a robust framework in applied quantum mechanics, statistical physics, and related fields.…”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Despite anecdotal reports linking multiple drugs to PV, corroborating evidence from large datasets is missing.ObjectiveTo examine the extent to which previously reported associations between a comprehensive list of 36 drugs implicated in PV pathogenesis could be replicated using population-level pharmacovigilance data.DesignSeries of observational, retrospective, case-control, pharmacovigilance analyses (one analysis/drug, 36 total).SettingPopulation based.ParticipantsIndividuals who submitted a report of a drug-related adverse event to the FDA from Q4 of 2003 to Q2 of 2023.ExposureCases were identified by the presence of adverse events described by the MedDRA preferred term “pemphigus” (10034280) and then sorted based on exposure to each of the drugs of interest.Main outcomes and measuresReporting Odds Ratios (RORs) quantifying the association between a given drug exposure and reports of pemphigus adverse events.ResultsThe analyses revealed statistically significant associations between reports of pemphigus and exposure to 11/36 previously reported drugs, two of which had particularly high RORs (&gt;200) [gold sodium thiomalate (ROR, 266.0; 95% CI, 202.6-349.3) and hydroxychloroquine (ROR, 282.6; 95% CI, 261.0-306.1)], three had very strong RORs (14-45) [penicillamine (ROR, 30.5; 95% CI, 11.4-81.7), piroxicam (ROR, 14.8; 95% CI, 8.2-26.7), and imiquimod (ROR, 42.3; 95% CI, 26.2-68.3)], and six had modestly strong RORs (2-5) [rifampin (ROR, 2.8; 95% CI, 1.4-5.6), hydrochlorothiazide (ROR, 1.6; 95% CI, 1.2-2.1), irbesartan (ROR, 2.7; 95% CI, 1.6-4.4), lisinopril (ROR, 5.3; 95% CI, 4.5-6.2), nivolumab (ROR, 2.7; 95% CI, 1.8-4.1), and nifedipine (ROR, 3.0; 95% CI, 1.9-5.0)]. …”
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Effectiveness of the Modified WHO Labour Care Guide to Detect Prolonged and Obstructed Labour Among Women Admitted at Eight Publicly Funded, Midwife-Led Community Health Facilities... by Mugyenyi GR, Tumuhimbise W, Atukunda EC, Tibaijuka L, Ngonzi J, Kayondo M, Kanyesigye M, Musimenta A, Yarine FT, Byamugisha JK

“…Data was collected in REDcap and analyzed using STATA v17; statistical significance was p < 0.05.Results: A total of 991 (49.3%) and 1020 (50.7%) women were monitored using the LCG and partograph, respectively. …”
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