Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster by Yasaman Heidarian, Tess D. Fasteen, Liam Mungcal, Kasun Buddika, Nader H. Mahmoudzadeh, Travis Nemkov, Angelo D'Alessandro, Jason M. Tennessen

“…Methods: CRISPR/Cas9 was used to generate new loss-of-function alleles in the Drosophila gene similar (sima), which encodes the sole fly ortholog of Hif1α. The resulting mutant strains were analyzed using a combination of metabolomics and RNAseq for defects in carbohydrate metabolism. …”
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Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports by Alessandro Ceschi, Roberta Noseda, Raffaela Bertoli, Laura Müller

“…The main outcome measures were co-suspected drugs, concurrent irAEs, HLH clinical, haematological and coagulation features, concomitant infections, HLH median time to onset and outcome.Results Among 49′883 ICI-related ADRs collated in VigiBase as of September 30th, 2018, HLH was reported in 38 cases of which 34 (90%) mentioned ICIs as the solely suspected drugs. ICI-related HLH showed clinical, haematological and coagulation features similar to those of HLH with different etiology. …”
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Novel Models for the Prediction of Left Atrial Appendage Thrombus in Patients with Chronic Nonvalvular Atrial Fibrillation by Do Van Chien, Pham Thai Giang, Pham Truong Son, Le Van Truong, Pham Nguyen Son

“…We hope these simple models can help with decision-making in managing the antithrombotic treatment of such patients, whose risk of stroke cannot be determined solely based on the CHA2DS2-VASc score.…”
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Outcomes of total hip replacement in adults with septic arthritis of the native hip joint: A systematic review by Teddy Cheong, Surya Varma Selvakumar, Ryan Kwang Jin Goh, Ing How Moo

“…However, to our knowledge, a consolidated review that focuses solely on THR outcomes in a previously infected native hip is still lacking. …”
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An Examination of Records Management in Private Sector Agencies in Kabale Municipality: A Case Study of Kigezi Private Sector. by Kakuru, Danis

“…Staff needs suitable working and recreational accommodation, following the standards in effect within the government or organization, there should be the provision of quality leadership to promote the efficient management of organizations' resources correctly, and there should be the provision of quality services to customers based on their needs that is changing the view of management from sole control to service, Enhance customer focus through strong partnerships; Commit to achieving high standards of customer services, there should be a need to provide high-quality information on federal government operations which fully supports financial and performance reporting, establish standards and definitions and all top management should be committed to implementing effective and efficient internal controls. …”
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Standardization and validation of a novel reverse transcriptase polymerase chain reaction method for detecting virulent strains of the infectious bursal disease virus by Vladimir Longa-Bobadilla, Phillip Ormeño-Vásquez, Manuel Criollo-Orozco, Luis Tataje-Lavanda, Katherine Huamán-Gutierrez, Ángela Montalván, Mirko Zimic, Manolo Fernández-Sanchez, Manolo Fernández-Díaz

“…Consequently, we focused on developing a novel reverse transcriptase polymerase chain reaction (RT-PCR) procedure solely for this purpose. Materials and Methods: Eight VP5 sequences were aligned, and the sequence with the majority of nucleotide coincidences was used to design a set of consensus primers. …”
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Alternative silencing states of transposable elements in Arabidopsis associated with H3K27me3 by Valentin Hure, Florence Piron-Prunier, Tamara Yehouessi, Clémentine Vitte, Aleksandra E. Kornienko, Gabrielle Adam, Magnus Nordborg, Angélique Déléris

“…Results In this study, we show that TEs can also be solely targeted and silenced by H3K27me3 in wild-type Arabidopsis plants. …”
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Trajectory of peripheral inflammation during index ECT in association with clinical outcomes in treatment-resistant depression by Christina M. Hough, Jennifer L. Kruse, Randall T. Espinoza, John O. Brooks, III, Eliza J. Congdon, Viviane Norris, Michelle G. Craske, Katherine L. Narr

“…Findings also highlight the importance of examining symptom-specific changes in depression when studying treatment mechanisms, rather than relying solely on global measures of severity.…”
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Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk by Xiaoye Liu, Kaiyang Liu, Jie Yang, Hui Qiao, Lai-Yu Kwok, Wenyi Zhang

“…We used Probio-M9 as the sole inoculant for milk fermentation, collecting samples at 1.5- to 3-h intervals to monitor fermentation progression. …”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

“…In the UK, non-pharmacological interventions are recommended for prehypertension management but no reviews have focused on the effectiveness of these types of interventions solely in people with prehypertension. Therefore, the proposed systematic review will assess the clinical effectiveness and cost-effectiveness of non-pharmacological interventions in reducing or maintaining blood pressure in prehypertensive people.Methods and analysis This systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. …”
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Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective... by Yukitaka Ueki, Tom W J Huizinga, René E M Toes, Shoichi Fukui, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami, Tomohiro Koga, Naoki Matsuoka, Toshihiko Hidaka, Naoki Iwamoto, Mami Tamai, Shin-ya Kawashiri, Akitomo Okada, Ayako Nishino, Tamami Yoshitama, Takahisa Suzuki, Toshimasa Shimizu, Shimpei Morimoto, Tomomi Tsuru, Karin A J van Schie, Masahiro Ayano, Remi Sumiyoshi, Yushiro Endo, Tohru Michitsuji, Kaori Furukawa, Masataka Umeda, Nobutaka Eiraku, Hiroaki Hamada

“…Logistic regression using baseline levels of anti-citrullinated protein antibody, IgM-anti-CCP2 positivity, the CDAI, the total power Doppler score, the cluster by cytokines and chemokines, MIP-1β, methotrexate dose and mechanisms of action revealed that cluster by cytokines and chemokines was the sole significant factor for CDAI remission at 12 months.Conclusions Specific patterns of cytokines and chemokines—no other clinical factors and autoantibody profiles—were important to distinguish patients with RA achieving remission at 12 months.Trial registration number UMIN000012524.…”
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Trabeculectomy versus stepwise treatment for breaking the attack of acute primary angle closure in patients with long attack duration: study design and protocol for a multicentre r... by Jing Jiang, Qing Zhang, Bo Qu, Chao Dai, Mingguang He, Ye Zhang, Ning-Li Wang, Shuning Li, Guangxian Tang, Su Jie Fan, Zhi Li, Chi Liu, Xinqi Chang, Yanyan Cheng

“…However, patients with APAC in China and developed countries differ in disease characteristics as the Chinese have longer attack duration and lower success rate in breaking the attack with solely medication or laser therapy. It has been proved that long attack duration is a risk factor for failed medical or laser therapies in subsiding APAC. …”
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Evaluation of nitrous oxide reduction in solid carbon source-driven counter-diffusional biofilm denitrification system by Yingrui Liu, Feng Chen, Yanying He, Yufen Wang, Tingting Zhu, Yindong Tong, Yingxin Zhao, Bing-Jie Ni, Yiwen Liu

“…Under the condition that TN concentration was maintained at 30 mg-N/L, the TN removal rate in the scheme containing NO3-+NO2-+N2O was observed to be 1.75–2.3 times higher than that of the scheme with sole NOx of 30 mg-N/L. This suggested that when treating wastewater containing multiple NOx, the PCL-driven biofilm denitrification system can not only relatively improve the total nitrogen removal efficiency, but also relatively alleviate N2O emissions. …”
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Is there a mental health diagnostic crisis in primary care? Current research practices in global mental health cannot answer that question by Brandon A. Kohrt, Dristy Gurung, Ritika Singh, Sauharda Rai, Mani Neupane, Elizabeth L. Turner, Alyssa Platt, Shifeng Sun, Kamal Gautam, Nagendra P. Luitel, Mark J.D. Jordans

“…Moreover, nearly all studies on detection focus solely on depression, not taking into account the spectrum of conditions on which primary healthcare workers are being trained. …”
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<i>MTHFR</i> Gene Polymorphisms and Cancer Risk in Children and Adolescents: A Systematic Review and Meta-Analysis by Savvas Kolanis, Eleni P. Kotanidou, Vasiliki Rengina Tsinopoulou, Elisavet Georgiou, Emmanuel Hatzipantelis, Liana Fidani, Assimina Galli-Tsinopoulou

“…<b>Background/Objectives:</b> <i>MTHFR</i> gene polymorphisms (677C>T and 1298A>C) correlate with various types of cancer across all age groups; however, a small number of studies have included solely children and adolescents. The aim of this systematic review and meta-analysis was to present and synthesize all the available evidence on the association between <i>MTHFR</i> gene polymorphisms and the incidence of all types of cancer in children and adolescences. …”
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The prognostic significance of tertiary lymphoid structures in oral squamous cell carcinomas: a systematic review by V. Ribeiro, J-L. Teillaud, J-L. Teillaud, J-L. Teillaud, M-C. Dieu-Nosjean, M-C. Dieu-Nosjean, M-C. Dieu-Nosjean, G. Lescaille, G. Lescaille, G. Lescaille, G. Lescaille, G. Lescaille, J. Rochefort, J. Rochefort, J. Rochefort, J. Rochefort, J. Rochefort

“…For instance, reports that are based solely on examining HES-stained slides for TLS identification may raise reliability concerns. …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…The protein-based vaccine approach is exemplified solely in a proof of concept study by using W-PreS-O, a chimeric vaccine based on a single fusion protein (W-PreS-O), combining RBDs from Wuhan hu-1 wild-type and Omicron BA.1 with the hepatitis B virus (HBV)-derived PreS surface antigen adsorbed to aluminum hydroxide. …”
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First Measurements of Ambient PM2.5 in Kinshasa, Democratic Republic of Congo and Brazzaville, Republic of Congo Using Field-calibrated Low-cost Sensors by Celeste McFarlane, Paulson Kasereka Isevulambire, Raymond Sinsi Lumbuenamo, Arnold Murphy Elouma Ndinga, Ranil Dhammapala, Xiaomeng Jin, V. Faye McNeill, Carl Malings, R. Subramanian, Daniel M. Westervelt

“…Finally, the surface PM2.5 level and the aerosol optical depth were about 40% lower during the COVID-19 lockdown in 2020 than the corresponding period in 2019, which cannot be attributed solely to changes in meteorology or wildfire emission. …”
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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits by Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

“…Taking advantage of zebrafish’s embryonic development that solely relys on yolk usage until 5 days post fertilization, we demonstrated that microglia proliferation and activation in the hypothalamus is independent from food intake. …”
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The role of mycobacteremia screening in enhancing non-tuberculous mycobacteria detection in hospitalized persons with HIV by Mengjiao Miao, Hongyan Zhu, Ziyao Liu, Jinjin Yang, Yiting Zhang, Chenyu Ma, Jiamin Qin, Yaling Chen, Hongxia Wei, Wei Chen, Yongfeng Yang, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu

“…Notably, mycobacteremia served as the sole microbiological evidence in approximately 25% of all culture-proven NTM infections during initial hospitalization, where other specimen sources failed to yield conclusive evidence. …”
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