Is There a Role for Bronchial Thermoplasty in the Treatment of Asthma? by Louis-Philippe Boulet, Michel Laviolette

“…It delivers thermal energy to the large airways during a bronchoscopy to decrease the amount of bronchial smooth muscle. This intervention has been shown to reduce asthma exacerbations, and improve asthma control and quality of life over a three-year period without significant complications up to a five-year period. …”
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Penile Rehabilitation Therapy with PDE-V Inhibitors Following Radical Prostatectomy: Proceed with Caution by M. Eric Brewer, Edward D. Kim

“…Erectile dysfunction is still a significant contributor to postoperative morbidity following radical prostatectomy, despite meticulous nerve-sparing technique. Secondary smooth muscle changes in the penis have been identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and fibrosis. …”
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Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations by Masahiro Murakami

“…While signaling pathways such as VEGF, FGF, and angiopoietin-Tie2 are important for endothelial cell survival and junction stabilization, PDGF and TGF-β signaling modify mural cell (vascular smooth muscle cells and pericytes) functions, thus they fortify vessel integrity. …”
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Multiple Oral Leiomyomas in an Infant: A Rare Case by Efraín Alvarez, María P. Laberry, Carlos M. Ardila

“…Oral leiomyoma is a benign smooth muscle tumor that occurs most frequently in the uterine myometrium, gastrointestinal tract, and skin. …”
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A Rare Case of Solitary Palatal Myofibroma in a Young Pediatric Patient by Tulika Wakhloo, Gosla Reddy, Ashi Chug, Arvind Kumar

“…The objective should be to differentiate benign versus malignant spindle cell lesions of smooth muscle, nerve tissue, fibrocytic, and histiocytic origin. …”
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Clinical, Imaging and Histopathology of Angioleiomyoma of the Buccal Cheek by Mohammad Jafarian, Fatemeh Mashhadi Abbas, Mitra Ghazizadeh Ahsaie, Homeira Saebnoori

“…Angioleiomyoma is a benign neoplasia originating from vascular smooth muscle and very uncommon in the oral cavity. In this report, we present a rare case of angioleiomyoma in oral cavity in a 46-year-old female buccal cheek and discuss the clinical, histological, and immunohistochemical characteristics. …”
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Fibrosarcoma of Mandible: A Case Report by Monal B. Yuwanati, J. V. Tupkari

“…Immunohistochemically the cells showed immunoreactivity only for vimentin while they exhibited negativity towards S-100 protein, cytokeratin cocktail, HMB-45, desmin, smooth muscle actin, and epithelial membrane antigen (EMA). …”
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Iatrogenic Ascending Aorta Dissection during Diagnostic Coronary Angiography: Rare but Life-Threatening by Marc Lambelin, Luc Janssens, Luc Haenen

“…A biopsy from the excised aorta showed loss of smooth muscle cells and accumulation of basophilic ground substance, clear features of cystic media necrosis. …”
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Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep by Andrew R. Williams

“…Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. …”
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The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics by Yahui Liu, Tian Liu, Jinxiang Wu, Tao Li, Xingai Jiao, Haiqing Zhang, Jiping Zhao, Junfei Wang, Lin Liu, Liuzhao Cao, Shuo Li, Jiawei Xu, Jianfeng Xu, Xiaohui Ma, Lei Yang, Liang Dong

“…FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened RBM. FSTL1 may contribute to airway remodeling in asthmatics.…”
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Leiomyoma in a Renal Allograft by Yan Jun Li, Amila Rohan Siriwardana, James Lawrence Penn Symons, Gordon Francis O’Neill, Min Ru Qiu, Timothy John Furlong

“…Leiomyomas are smooth muscle tumours that are rarely found in the kidney. …”
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Atherogenic Factors and Their Epigenetic Relationships by Ana Z. Fernandez, Andrew L. Siebel, Assam El-Osta

“…Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. …”
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Genetics of Cerebral Vasospasm by Travis R. Ladner, Scott L. Zuckerman, J Mocco

“…It is thought that an inflammatory cascade initiated by extravasated blood products precipitates CV, disrupting vascular smooth muscle cell function of major cerebral arteries, leading to vasoconstriction. …”
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The Molecular Genetics and Cellular Mechanisms Underlying Pulmonary Arterial Hypertension by Rajiv D. Machado

“…The small pulmonary arteries of patients exhibit luminal occlusion resultant from the uncontrolled growth of endothelial and smooth muscle cells. This vascular remodelling is comprised of hallmark defects, most notably the plexiform lesion. …”
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Heparan sulphate inhibition of cell proliferation induced by TGFβ and PDGF by lan E. Silber, Jeanine M. Walenga, Jawed Fareed, Elizabeth J. Kovacs

“…The effect of glycosaminoglycans (GAGs) on the proliferation of smooth muscle cells (SMC) and fibroblasts was assessed by culturing cells with or without GAGs. …”
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Acetylcholine in irritable bowel syndrome pathogenesis and the role of cholineblockers by Yu. O. Shulpekova

“…Experimental data allow to assume, that «subclinical inflammation» within intestinal wall at IBS, disturbances of peristaltic activity and hyperalgesia, are related to altered response of immune and smooth-muscle cells to acetylcholine stimulation.Conclusion. …”
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Nitric oxide function in atherosclerosis by K. E. Matthys, H. Bult

“…Most evidence supports the hypothesis that constitutive endothelial NO release protects against atherogenesis e.g. by preventing smooth muscle cell proliferation and leukocyte adhesion. …”
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The therapeutic agents that target ATP-sensitive potassium channels by Rubaiy Hussein N.

“…Also, KATP channels are involved in the protection against neuronal seizures and ischaemic stress in the heart, brain and in the regulation of vascular smooth muscle tone. Functional KATP channels are hetero-octamers composed of two subunits, a pore forming Kir6, which is a member of the inwardly rectifying potassium channels family, and a regulatory sulphonylurea receptor (SUR). …”
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β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques by Taisuke Okano, Kengo Sato, Remina Shirai, Tomomi Seki, Koichiro Shibata, Tomoyuki Yamashita, Ayaka Koide, Hitomi Tezuka, Yusaku Mori, Tsutomu Hirano, Takuya Watanabe

“…Chronic β-endorphin infusion into Apoe−/− mice significantly aggravated the development of aortic atherosclerotic lesions, with an increase in vascular inflammation and the intraplaque macrophage/smooth muscle cell ratio, an index of plaque instability. …”
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Hepatic Abnormal Secretion of Apolipoprotein C3 Promotes Inflammation in Aortic Dissection by Xinghui Zhuang, Mohammad Zarif, Yue Shen, Zhaofeng Zhang, Jian He, Linfeng Xie, Qingsong Wu, Xinfan Lin, Keyuan Chen, Yue Tian, Yong Lin, Yuling Zhang, Ziwen Cai, Zhihuang Qiu, Liangwan Chen

“…Additionally, the effect of apo C3 on the function of aortic endothelial and smooth muscle cells was explored. Apo C3 in the aortas of AD mice was found to originate from abnormal hepatic secretion, which enters the bloodstream and subsequently deposits in the aorta. …”
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