Expression of SIRT1 and DBC1 in Developing and Adult Retinas by Shawn C. Maloney, Emilia Antecka, Alexandre N. Odashiro, Bruno F. Fernandes, Madeline Doyle, Li-Anne Lim, Yousef Katib, Miguel N. Burnier

“…Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. …”
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Structural basis of SIRT7 nucleosome engagement and substrate specificity by Carlos Moreno-Yruela, Babatunde E. Ekundayo, Polina N. Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

“…We show that the SIRT7 N-terminus represents a unique, extended nucleosome-binding domain, reaching across the nucleosomal surface to the acidic patch. …”
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Genetic Variants of SIRT1 Gene Promoter in Type 2 Diabetes by Shuchao Pang, Zhengjun Zhang, Yu Zhou, Jie Zhang, Bo Yan

“…Thus, we speculated that altered SIRT1 levels, resulting from the genetic variants within its regulatory region of SIRT1 gene, may contribute to the T2D development. …”
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PCSK9 affects vascular senescence through the SIRT1 pathway by Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong

“…Therefore, PCSK9 inhibitors can delay the aging of the vascular by reducing cellular SIRT1 levels. Therefore, it can be concluded that PCSK9 inhibition inhibits vascular senescence by reducing the expression of senescent proteins by regulating the SIRT1 pathway.…”
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SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity by Ke Wang, Zuojian Hu, Cuiping Zhang, Lujie Yang, Li Feng, Pengyuan Yang, Hongxiu Yu

“…Over the past several years, SIRT5 has attracted considerable attention in metabolic regulation. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

Subjects: “…SIRT5…”
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Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1 by Xinxin Li, Jinghua Cui, Zanbo Ding, Ziyan Tian, Yiming Kong, Linghai Li, Yang Liu, Wen Zhao, Xueying Chen, Han Guo, Zhengshuo Cui, Xinwei Li, Jing Yuan, Huina Zhang

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miR-197 Participates in Lipopolysaccharide-Induced Cardiomyocyte Injury by Modulating SIRT1 by Miaomiao Liu, Ying Zhang, Xiantong Cao, Tao Shi, Yang Yan

“…The protective role of miR-197 downregulation in LPS-induced H9c2 cells was reversed by SIRT1 silencing. miR-197 contributed to LPS-induced cardiomyocyte injury by modulating SIRT1, which might be used as a molecular marker in the management of sepsis.…”
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Does SIRT-1 Mediate Calorie Restriction and Prolong Life? – A Mini Review by Kordala Anna, Pietrzak Bogusława

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Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer by J. Kabzinski, A. Walczak, I. Majsterek

“…In this work, we show that NEIL1, NEIL2, MUTYH, APE1, and LIG3 are regulated by Sirt3 through deacetylation, and moreover, Sirt3 is directly involved in physical interaction with MUTYH, NEIL1, and APE1, which indicates the controlling role of Sirt3 over the mtBER mechanism. …”
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Potential therapeutic effects of SIRT1 targeting APOE4-induced microvascular endothelial dysfunction by Yorito Hattori, Masafumi Ihara

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N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1 by Toru Miwa, Toru Miwa, Akihito Tarui, Akihito Tarui, Teppei Kouga, Yasunori Asai, Yasunori Asai, Hideaki Ogita, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba, Nobuhiro Hakuba

“…Sirtuins, particularly SIRT1, are NAD-dependent protein deacetylases critical to aging and stress responses. …”
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Role of sirtuin 1 (SIRT1) gene polymorphisms in pituitary adenoma development. Literature review by G. Morkūnaitė, B. Glebauskienė, R. Liutkevičienė

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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

Subjects: “…SIRT5…”
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SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease by Mridula Bhalla, Jinhyeong Joo, Daeun Kim, Jeong Im Shin, Yongmin Mason Park, Yeon Ha Ju, Uiyeol Park, Seonguk Yoo, Seung Jae Hyeon, Hyunbeom Lee, Junghee Lee, Hoon Ryu, C. Justin Lee

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Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…The data suggest that SIRT2 may be a key target affecting these processes.…”
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Sevoflurane Ameliorates Myocardial Cell Injury by Inducing Autophagy via the Deacetylation of LC3 by SIRT1 by Lihua Fan, Deyuan Chen, Jianping Wang, Yini Wu, Dongli Li, Xiaoyan Yu

“…Sevoflurane increased the level of SIRT1, which deacetylated LC3 and further increased autophagic rates. …”
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Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes by Chunzi Liang, Benjamin J. Curry, Patricia L. Brown, Michael B. Zemel

“…Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD+, SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event.…”
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Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia by Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran

“…Results As a result of NAD+ being a common substrate for PARP1 and Sirtuins, we found the decreased expression of SIRT1, SIRT3, and NRF2, a central transcriptional regulator for the expression of antioxidant genes. …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6.…”
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