Development and Validation of a Predictive Model Based on Serum Silent Information Regulator 6 Levels in Chinese Older Adult Patients: Cross-Sectional Descriptive Study by Yuzi You, Wei Liang, Yajie Zhao

“… Abstract BackgroundSerum levels of silent information regulator 6 (SIRT6), a key biomarker of aging, were identified as a predictor of coronary artery disease (CAD), but whether SIRT6 can distinguish severity of coronary artery lesions in older adult patients is unknown. …”
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The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease by Farshad Amirkhizi, Mahdiyeh Taghizadeh, Banafshe Khalese-Ranjbar, Soudabeh Hamedi-Shahraki, Somayyeh Asghari

“…This indicates that serum Sirt-1 levels below 23.75 ng/mL may be indicative of MASLD. …”
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Selective Internal Radiation Therapy for Gastrointestinal Neuroendocrine Tumour Liver Metastases: A New and Effective Modality for Treatment by Harshal Rajekar, Kashan Bogammana, Richard S. Stubbs

“…Repeat SIRT was undertaken in three patients after 16, 27, and 48 months, respectively. …”
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Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres by Felipe Nasser, Joaquim Maurício Motta Leal Filho, Breno Boueri Affonso, Francisco Leonardo Galastri, Rafael Noronha Cavalcante, Diego Lima Nava Martins, Vanderlei Segatelli, Lilian Yuri Itaya Yamaga, Rene Claudio Gansl, Bernardino Tranchesi Junior, Antônio Luiz de Vasconcellos Macedo

“…Conclusion. SIRT had a positive effect on liver metastases from PACC. …”
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Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice by Ayana N. Martin, Martha Alexander-Miller, Barbara K. Yoza, Vidula Vachharajani, Charles E. McCall

“…NAD+-sensing nuclear sirtuin1 (SIRT1) epigenetically guards immune and metabolic homeostasis during sepsis. …”
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Mitochondrial Dysfunction and Sirtuins: Important Targets in Hearing Loss by Lingjun Zhang, Zhengde Du, Shusheng Gong

“…Although the precise functions of SIRT4 and SIRT5 in the cochlea remain unclear, the molecular mechanisms in other tissues indicate a potential protective effect against hearing loss. …”
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The Role of 18F-FDG-PET and PET/CT in Patients with Colorectal Liver Metastases Undergoing Selective Internal Radiation Therapy with Yttrium-90: A First Evidence-Based Review by Salvatore Annunziata, Giorgio Treglia, Carmelo Caldarella, Federica Galiandro

“…A comprehensive computer literature search was conducted to find relevant published articles on whole-body FDG-PET or PET/CT in patients with CRLM undergoing SIRT. Results. We identified 19 studies including 833 patients with CRLM undergoing SIRT. …”
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Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats by S. Rossi, C. Di Filippo, C. Gesualdo, F. Testa, M. C. Trotta, R. Maisto, B. Ferraro, F. Ferraraccio, M. Accardo, F. Simonelli, M. D’Amico

“…Therefore, an interplay of the SIRT1 activity on the RvD1 mediated resolution of EIU is argued.…”
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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…SiRNA-induced inhibition of either Nrf2 or Sirt3 blocked IGF-1-induced upregulation of mitophagy, suggesting that the Nrf2/Sirt3 pathway was required for IGF-1’s effect on mitophagy. …”
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Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose by Can Wu, Ningning Qin, Huiwen Ren, Min Yang, Shuang Liu, Qiuyue Wang

“…Activating AMPKα negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPKα through mediating SIRT1 to suppress the development of fatty liver. …”
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Alterations in mRNA level of proteins related to redox state and mitochondria in an Alzheimer’s disease animal model: Promising targets in neuroprotection by Sylwia Żulińska, Przemysław L. Wencel, Kinga Czubowicz, Joanna B. Strosznajder

“…In summary, our data identified significant changes in gene expression of Sod2, Parp1 and Sirt1 at an early age (3-6-month-old AD mice) then Ppargc1, Nfe2L2 and Sirt1 at a later age. …”
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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. …”
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ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway by Xi Zhu, Xiaogang Zhang, Xinpeng Cong, Luoning Zhu, Zhongping Ning

“…Mechanistically, ANGPTL4 inhibited the activation of several fatty acid metabolism-related proteins, including PPARα, PPARγ, and CPT-1, and the expression of SIRT3 protein in atrial tissues. In conclusion, ANGPTL4 attenuates Ang II-induced AF and atrial fibrosis by modulation in the SIRT3, PPARα, and PPARγ signaling pathways.…”
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Activation of Opioid Receptors Attenuates Ischemia/Reperfusion Injury in Skeletal Muscle Induced by Tourniquet Placement by Yue-Xian Guo, Gui-Ying Wang, Wen-jie Cheng, Cai-Zhen Yan, Shuang Zhao, Zhao Li, Peng Liu, Xiu-Li Wang

“…Expression levels of TLR4, NF-κB, SIRT1, and PGC-1α in the skeletal muscles were detected by western blot. …”
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PGC-1α Promotes mitochondrial biosynthesis and energy metabolism of goose fatty liver by Jiahui Li, Mengqing Lv, Zijin Yuan, Jing Ge, Tuoyu Geng, Daoqing Gong, Minmeng Zhao

“…The mRNA expression levels of PGC-1β, SIRT3, SIRT5, CYTB, and AMPKα were significantly enhanced after PGC-1α overexpression. …”
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Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats by Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie

“…ELISA and Western blotting assessed inflammatory markers (TNF-α, IL-10), SIRT1, GSK-3β, and AQP2 expressions in kidney tissues. …”
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Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 by Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang

“…In response to chronic‐plus‐binge ethanol feeding or fasting, ethyl lactate mimics lipogenesis lowering effects by stimulating FGF21 production through the NAD+‐dependent deacetylase sirtuin 1 (SIRT1) signaling pathway. These ethyl lactate‐mediated beneficial effects are abolished by inhibition of SIRT1 through injection of EX527. …”
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The relationship of lamins with epigenetic factors during aging by R. N. Mustafin, E. K. Khusnutdinova

“…Epigenetic regulators such as SIRT7, BAF, and microRNA can also serve as intermediaries for their interactions. …”
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Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition by Afnan Deebani, Jabila Mary, Sanchi Dhinoja, Ayah Al Qaryoute, Weam Fallatah, Pudur Jagadeeswaran

“…Further analysis revealed increased sirt6 and nrf2 transcripts after tmem242 knockdown, with their knockdown reducing f9a levels. …”
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Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury by Vladislav N. Karkischenko, Veronika I. Skvortsova, Melik T. Gasanov, Yuriy V. Fokin, Maxim S. Nesterov, Nataliya V. Petrova, Oxana V. Alimkina, Igor A. Pomytkin

“…The mechanism of action involves preventing HMGB1’s hyperacetylation at critical lysine residues within nuclear localization sites, as well as promoting the expression of sirtuin 1 (SIRT1), an enzyme known to deacetylate HMGB1. Leytragin’s effects are mediated by opioid receptors, since naloxone, an antagonist of opioid receptors, abrogates the leytragin effect on SIRT1 expression. …”
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