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    Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection by Yin H, Li X, Lu D, Zhao X, Yang Z, Wang Z, Xu F, Chen Y, Li C

    Published 2025-02-01
    “…Hang Yin,1– 5,* Xiaoxing Li,6,* Dazhou Lu,1– 5,* Xin Zhao,7,* Zeyu Yang,1– 5 Zerui Wang,1– 5 Feng Xu,1– 5 Yuguo Chen,1– 5 Chuanbao Li1– 5 1Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 3Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 4Shandong Key Laboratory: Magnetic Field-Free Medicine & Functional Imaging (MF), Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 5NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 6Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 7Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuanbao Li; Yuguo Chen, Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China, Email bao2460@126.com; chen919085@sdu.edu.cnBackground: Aortic dissection (AD) is a life-threatening cardiovascular emergency and currently lacks effective drug treatment. …”
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