What motivates older adult learners in Poland to study foreign languages in later life? by Agata Słowik-Krogulec

“…Three major findings were identified in this study: (a) older adults take up learning languages in later life in order to communicate while travelling (also with their families who live abroad); to socialise and get to know new people and cultures; to maintain intellectual abilities and to develop cognitively; (b) the instructor and other learners are key components in improving older adults’ motivation; and (c) stereotypes related to senescence and to Foreign Language Geragogy should be challenged to make classes relevant and interesting for this age group.…”
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Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes by Li Zhang, Yang Luo, Hai-Li Shen

“…This review examines the molecular alterations in RA FLSs in the context of systemic immune aging, with a focus on thymic insufficiency-associated T cell senescence, and explores potential therapeutic avenues.…”
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Ecogeographical Amplitude and Habitat of Two Species of the Genus- <i>Terminalia</i> (Combretaceae) In the Central Niger Delta Areas in Rivers State by NL Edwin-Wosu, T Omara-Achong, BL Nyannanyo

“…Both species are deciduous with annual foliar senescence. Both species were also observed to be utilized for different purposes such as environmental conservation, beautification, parks and habitat and as shade creating plants and domestic source of fuel in the Central Niger Delta…”
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Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective by Mario Di Napoli, Imtiaz M. Shah

“…This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.…”
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Aging-enhanced autophagy activity promotes fibrotic progression via the TGF-β2/Smad signaling pathway in trabecular meshwork cells—a new insight from POAG by Jin Han, Jun Wang, Ling Shen, Yiting Cai, Xuze Wang, Ailixiati Wumaier, Wei Chen, Wei Han

“…These findings underscore the important role of autophagy in POAG pathogenesis and confirm senescence as a pivotal risk factor.…”
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An Efficient Method for Immortalizing Mouse Embryonic Fibroblasts by CRISPR-mediated Deletion of the Tp53 Gene by Srisathya Srinivasan, Hsin-Yi Ho

“…However, primary MEFs undergo senescence soon after isolation and passaging, making long-term genetic manipulations difficult. …”
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Different Levels of Autophagy Activity in Mesenchymal Stem Cells Are Involved in the Progression of Idiopathic Pulmonary Fibrosis by Hongxia Tao, Qin Lv, Jing Zhang, Lijuan Chen, Yang Yang, Wei Sun

“…Therefore, this review focuses on the changes in autophagic activity of MSCs, clarifies the relationship between autophagy and health status of MSCs and the effect of autophagic activity on MSCs senescence and IPF, providing a theoretical basis for promoting the clinical application of MSCs.…”
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Association of p53 with Neurodegeneration in Parkinson’s Disease by Qiang Luo, Wei Sun, Yi-Fan Wang, Ji Li, Da-Wei Li

“…p53 is a vital transcriptional protein implicated in regulating diverse cellular processes, including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis, autophagy, senescence, and apoptosis. Recent studies have revealed that p53 levels and activity are substantially increased in affected neurons in cellular and animal models of Parkinson’s disease (PD) as well as in the brains of PD patients. p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. …”
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Age-Dependent Constraints of Sex Allocation in a Parasitoid Wasp by Takatoshi Ueno

“…Physiological constraints such as sperm depletion and senescence are a likely cause. Also, maternal control in response to female age may be an alternative explanation. …”
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Sirtuin activators as an anti-aging intervention for longevity by Puja Sah, Anita K. Rai, Donkupar Syiem

“…The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis, cellular senescence, oxidative stress, and mitochondrial production. …”
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PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium by Lucie Bienfait, Nicky D’Haene, Xavier Catteau, Jean-Christophe Noël

“…Nevertheless, in endometrial lymphoepithelioma-like carcinoma, the alterations on cell cycle, apoptosis, and/or senescence secondary to p53 mutations could potentially be counterbalanced by the antitumoral response induced by CD8 cytotoxic T-lymphocytes numerous in these tumors.…”
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Physical Activity and Telomere Biology: Exploring the Link with Aging-Related Disease Prevention by Andrew T. Ludlow, Stephen M. Roth

“…A long-standing hypothesis of aging is the telomere hypothesis: as a cell divides, telomeres shorten resulting eventually in replicative senescence and an aged phenotype. Several reports have recently associated telomeres and telomere-related proteins to diseases associated with physical inactivity and aging including cardiovascular disease, insulin resistance, and hypertension. …”
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Effect of compost formulation and postharvest management on quality parameters of button mushroom by Mohammad Ebrahim Ranjbar, Zahra Ghahremani

“…Quality parameters including color (browning due to microbial activity), cap opening and the weight loss (senescence) were evaluated. Results The nature of the manure employed as base material in the substrate can affect the postharvest browning ratio of mushroom. …”
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Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review by Endah

“…Overall, the anti-aging properties of black pepper and its constituents are exhibited through several pathways, including senescence prevention, antioxidant protection, control of ROS levels, and the inhibition of aging-related enzymes. …”
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The future of physiological research: A greater understanding of female master athletes and aging? by Lorcan S. Daly

“…Such analyses would improve our understanding of senescence in women and may inform interventions targeting the promotion of physical function in older adults.…”
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Artificial Light at Night (ALAN) as an Emerging Urban Stressor for Tree Phenology and Physiology: A Review by Luisa Friulla, Laura Varone

“…Changes in phenology such as delayed senescence and altered budburst timing demonstrated species-specific responses, often compounded by other urban stressors like heat and drought. …”
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A Hypothesis Concerning a Potential Involvement of Ceramide in Apoptosis and Acantholysis Induced by Pemphigus Autoantibodies by Wendy B. Bollag

“…Our hypothesis is that: (1) the autoantibodies generate pathology through an alteration in ceramide metabolism in targeted keratinocytes, resulting in apoptosis and/or cell death and acantholysis, but only when the cell's ability to metabolize ceramide is exceeded, and (2) apoptosis in response to this altered ceramide metabolism is initiated and/or exacerbated by other agents that increase ceramide levels, such as cytokines, ultraviolet irradiation, and senescence.…”
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Hemoglobin: A Nitric-Oxide Dioxygenase by Paul R. Gardner

“…NOD knockout organisms and cells expressing recombinant NODs are helping to advance our understanding of NO actions in microbial infection, plant senescence, cancer, mitochondrial function, iron metabolism, and tissue O2 homeostasis. …”
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Higher-Order Chromatin Regulation of Inflammatory Gene Expression by Jin-Wen Xu, Shuang Ling, Jun Liu

“…Whether it is caused by viruses and bacteria infection, or low-grade chronic inflammation of atherosclerosis and cellular senescence, the transcription factor (TF) NF-κB plays a central role in the inducible expression of inflammatory genes. …”
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Mechanisms of liver disease in patients infected with HIV by Matthew B Kaspar, Richard K Sterling

“…A thorough understanding of the mechanisms driving the development of liver disease in these patients is essential when evaluating and caring for these patients.Methods The literature regarding mechanisms of liver disease by which different disease entities may cause hepatic injury and fibrosis was reviewed and synthesised.Results A number of discrete mechanisms of injury were identified, to include: oxidative stress, mitochondrial injury, lipotoxicity, immune-mediated injury, cytotoxicity, toxic metabolite accumulation, gut microbial translocation, systemic inflammation, senescence and nodular regenerative hyperplasia. Disease states may use any number of these mechanisms to exert their effect on the liver.Conclusions The mechanisms by which liver injury may occur in patients with HIV infection are numerous. …”
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