Age-dependent decline in sperm quality and function in a naturally short-lived vertebrate by Silvia Cattelan, Dario Riccardo Valenzano

“…Our findings question generalized soma vs. reproductive senescence trade-off models and highlight the importance of integrating species-specific ecological and demographic constraints to explain observed life history traits.…”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…One factor contributing to this therapeutic barrier could be the presence of senescent cells in OA joints. Methods This study evaluated a novel approach to OA treatment by combining adipose tissue-derived MSCs (AD-MSCs) with rapamycin, a clinically approved immunosuppressive drug with anti-senescence properties. …”
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Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation by Katja C. Weisel, Frank Bautz, Gabriele Seitz, Sedat Yildirim, Lothar Kanz, Robert Möhle

“…Partially retained responsiveness to interleukin-8 may be important for neutrophil function when senescence occurs after extravasation in inflamed tissues.…”
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HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats by Rathasapa Patarat, Suchanart Chuaybudda, Sakawdaurn Yasom, Apiwat Mutirangura

“…The upstream pathogenesis of pulmonary fibrosis may involve cellular senescence of the lung tissue. Previously, a new gene therapy technology using Box A of the HMGB1 plasmid (Box A) was used to reverse cellular senescence and cure liver fibrosis in aged rats. …”
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ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells by Lijing Qin, Geng Tang, Ruirui Gui, Yanming Yang, Li Wang, Weiqiang Xu, Hongyuan Tian, Lei Yu, Xiangshan Yang, Zhicheng Wang

“…To explore the potential mechanism, we focused on the impact of the ionizing radiation (IR)-induced DNA damage response (DDR), apoptosis, and senescence and the activation of the Daxx/MDM2/p53 pathway caused by ATRX loss. …”
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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…Osteoarthritis (OA) is an age-related chronic inflammatory disease, predominantly characterized by chondrocyte senescence and extracellular matrix (ECM) degradation. …”
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Effect of melatonin on the contents of fatty acids and antioxidants of saffron by Mohammad Mehdi Samim, Ali Sorooshzadeh, Ali Mokhtassi-Bidgoli, Mohammad Sadegh Sabet

“…Early leaf senescence at the end of the growing season poses a significant challenge in saffron cultivation. …”
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Effects of 1-Methylcyclopropene Treatment on Physicochemical Attributes of “Hai Jiang” Yardlong Bean during Cold Storage by Zitao Jiang, Jiaoke Zeng, Yunke Zheng, Hong Tang, Wen Li

“…Of the different concentrations of 1-MCP, 1.0 μL·L−1 proved to have the best preservative effects, extending storage time and delaying ripening and senescence of yardlong beans. These results indicated that 1-MCP treatment provided an effective method for delaying the postharvest senescence of fresh yardlong beans.…”
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Cellular Response upon Stress: p57 Contribution to the Final Outcome by Marianna Nicoletta Rossi, Fabrizio Antonangeli

“…Furthermore, it is nowadays emerging that p57 plays a role in the induction of apoptosis and senescence after cellular stress independently of its cell cycle related functions. …”
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Markers of immunosenescence in CMV seropositive healthy elderly adults by Ivón Johanna Rodríguez, Carlos Alberto Parra-López

“…In this sense, this work aimed to identify senescence markers in cells of the innate and adaptive immune system in healthy older adults with CMV infection. …”
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Potential Research Tool of Stem Cells from Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization with EGFP Marker by Siqi Yao, Lingping Tan, Huan Chen, Xiaojun Huang, Wei Zhao, Yan Wang

“…Replicative lifespan determination and colony-forming efficiency assessment were using to assay proliferation capability. Senescence-associated β-galactosidase assay was performed to assay the senescence level of cells. …”
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Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells by Vladimir F. Niculescu

“…Oxygen-sensitive germline and stem cells suffer DNA double-strand breaks due to stress and oxygen ranges reminiscent of ancestral hyperoxia, leading to cell senescence. Cells that can overcome senescence can proliferate as defective symmetric cell division, paving the way for malignancy and polyploid giant cancer cell cancers. …”
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Bois pourri et santé des forêts : exemple du mélange épicéa (Picea abies [L.] Karst.) et mélèze (Larix decidua Mill.) en forêt subalpine de Sainte-Foy-Tarentaise (Savoie) by Nicolas Bernier, Jean-Yves Trosset

“…Messages clés : - Sénescence et régénération sont interdépendants. Ils sont le reflet de la santé de la forêt. - Le bois mort au sol n’est que « la partie émergée de l’iceberg ». …”
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PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress by Chujie Chen, Jinyan He, Weixian Huang, Dong Xu, Zhaohui Li, Anqi Yang

“…These DEGs were significantly enriched in critical aging pathways, including the p53 signaling pathway, autophagy, and cellular senescence. Protein-protein interaction (PPI) network analysis unveiled 15 key genes related to cell cycle and DNA replication, with polo-like kinase 3 (PLK3) exhibiting increased expression under OS. …”
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Decoding vascular aging: implications for atherosclerosis progression and clinical intervention by Silumbwe Ceaser Wankumbu, Xiao-Man Ji, Ming Xu

“…It is important to note that the mechanisms are equally interrelated with other aging pathways, such as inflammation and senescence. In conclusion, atherosclerosis is multifaceted and cholesterol-lowering therapy has been widely used. …”
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Constructing Tissue-Engineered Dressing Membranes with Adipose-Derived Stem Cells and Acellular Dermal Matrix for Diabetic Wound Healing: A Comparative Study of Hypoxia- or Normoxi... by Wen Zhou, Xin Zhao, Xin Shi, Can Chen, Yanpeng Cao, Jun Liu

“…Meanwhile, most of injected cells gradually perished within several days due to senescence or apoptosis. Acellular dermal matrix (ADM) has the potential to act as excellent cell delivery vehicles, considering it is highly biomimetic to native dermal tissue, has low immunogenicity, and suitable for stem cell attachment and proliferation. …”
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Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging by Yu-Sheng Huang, Jia-Wen Gao, Rui-Feng Ao, Xin-Yu Liu, Di-Zheng Wu, Jun-Long Huang, Chen Tu, Jing-Shen Zhuang, Si-Yuan Zhu, Zhao-Ming Zhong

“…Compared with MSCs from young mice, MSCs from aged mice tended to differentiate into adipocytes rather than osteoblasts and displayed cellular senescence. Exposure of primary MSCs to AOPPs resulted in the switch from osteogenic to adipogenic lineage and cellular senescence. …”
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Photosynthetic traits of Phragmites australis along an ecological gradient and developmental stages by Viktor R. Tóth, Viktor R. Tóth

“…Senescence affected the plasticity of plant traits independently of their degradation status, suggesting a more universal nature of seasonal changes. …”
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Water Use Efficiency and Physiological Response of Rice Cultivars under Alternate Wetting and Drying Conditions by Yunbo Zhang, Qiyuan Tang, Shaobing Peng, Danying Xing, Jianquan Qin, Rebecca C. Laza, Bermenito R. Punzalan

“…AWD treatments accelerated the grain filling rate, shortened grain filling period, and enhanced whole plant senescence. Under normal dry-season conditions, such as 2010 DS, AWD reduced water input by 24.5% than CF; however, it decreased grain yield by 6.9% due to accelerated leaf senescence. …”
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Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats by Yachao Zhao, Zhiwei Jia, Shanshan Huang, Yaohong Wu, Longgang Liu, Linghan Lin, Deli Wang, Qing He, Dike Ruan

“…The functions of mesenchymal stem cells (MSCs) appear to decline with age due to cellular senescence, which could reduce the efficacy of MSCs-based therapies. …”
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