Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…We calculated the prevalence of SMI by UK country, English region and deprivation quintile, antipsychotic and antidepressant medication prescription rates for people with SMI, and prevalence rates of common comorbidities in people with SMI compared with people without SMI.Design Retrospective cohort study from 2000 to 2012.Setting 627 general practices contributing to the Clinical Practice Research Datalink, a UK primary care database.Participants Each identified case (346 551) was matched for age, sex and general practice with 5 randomly selected control cases (1 732 755) with no diagnosis of SMI in each yearly time point.Outcome measures Prevalence rates were calculated for 16 conditions.Results SMI rates were highest in Scotland and in more deprived areas. Rates increased in England, Wales and Northern Ireland over time, with the largest increase in Northern Ireland (0.48% in 2000/2001 to 0.69% in 2011/2012). …”
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Assessment of the validity and reliability of the nurses’ professional values scale—revised in Persian version among nursing students by Fahimeh Alsadat Hosseini, Ladan Zarshenas, Kobra Parvan, Maryam Shaygan, Banafsheh Tehranineshat, Brian Thomson

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Segmental analysis of human hair reveals intra-annual variation in 25(OH)D3 concentrations in modern and archaeological individuals by Kate Britton, Orsolya Czére, Eléa Gutierrez, Linda M. Reynard, Eamon Laird, Gary Duncan, Baukje de Roos

“…Here, we determined 25(OH)D3 concentrations in hair specimens (‘locks’) that had been sampled close to the root, aligned by cut end, and sliced into sequential segments from participants (n = 16), from Aberdeen, Scotland, using a modified protocol designed to minimise sample size. …”
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Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model by Morag Livingstone, Kevin Aitchison, Javier Palarea-Albaladejo, Francesco Ciampi, Clare Underwood, Antonia Paladino, Francesca Chianini, Gary Entrican, Sean Ranjan Wattegedera, David Longbottom

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Exploring public support for novel tobacco and alcohol control policies in Great Britain 2021–2023: A population-based cross-sectional survey by Vera Helen Buss, Lion Shahab, Sharon Cox, Loren Kock, Melissa Oldham, Linda Bauld, Hazel Cheeseman, Garth Reid, Jamie Brown

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Who is engaging with lateral flow testing for COVID-19 in the UK? The COVID-19 Rapid Survey of Adherence to Interventions and Responses (CORSAIR) study by Nicola T Fear, Susan Michie, Richard Amlot, G James Rubin, Louise E Smith, Henry WW Potts

“…Objectives To investigate uptake of lateral flow testing, reporting of test results and psychological, contextual and socio-demographic factors associated with testing.Design A series of four fortnightly online cross-sectional surveys.Setting Data collected from 19 April 2021 to 2 June 2021.Participants People living in England and Scotland, aged 18 years or over, excluding those who reported their most recent test was a polymerase chain reaction (PCR) test (n=6646, n≈1600 per survey).Main outcome measures Having completed at least one lateral flow test (LFT) in the last 7 days.Results We used binary logistic regressions to investigate factors associated with having taken at least one LFT. …”
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Functional Fitness and Self-Reported Quality of Life of Older Women Diagnosed with Knee Osteoarthrosis: A Cross-Sectional Case Control Study by Paula Andréa Malveira Cavalcante, Márcio Roberto Doro, Frank Shiguemitsu Suzuki, Roberta Luksevicius Rica, Andrey Jorge Serra, Francisco Luciano Pontes Junior, Alexandre Lopes Evangelista, Aylton José Figueira Junior, Julien Steven Baker, Danilo Sales Bocalini

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Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain by Colin Berry, Alex McConnachie, Peter Kellman, Terry Quinn, Paul Donnelly, Vanessa Orchard, Robert A Sykes, Gemma McKinley, Conor Patrick Bradley, Jodi Watt, Natasha Fullerton

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Non-communicable airway disease and air pollution in three African Countries: Benin, Cameroon and The Gambia by B. Awokola, H. Lawin, O. Johnson, A. Humphrey, D. Nzogo, L. Zubar, G. Okello, S. Semple, E. Awokola, G. Amusa, N. Mohammed, C. Jewell, A. Erhart, K. Mortimer, G. Devereux, B.H. Mbatchou-Ngahane

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Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after s... by Gozde Ozakinci, Stephan U Dombrowski, Andrew Murphy, Albert Farre, Jenna Breckenridge, Jacqui H Morris, Linda A Irvine, Keith Jenkinson

“…Objectives To test the feasibility and acceptability of a text-message-delivered behavioural intervention to promote and maintain physical activity and recovery after stroke rehabilitation.Design A single-arm acceptability and feasibility study.Setting Community rehabilitation services in two Health Board areas in Scotland.Participants People with stroke who could participate in physical activities and use a mobile phone were recruited during rehabilitation and community rehabilitation.Intervention Keeping Active with Texting after Stroke (KATS) is an automated text message-delivered intervention informed by behaviour change theory. …”
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Healthy dietary patterns and the incidence of chronic kidney disease: results from a prospective cohort study by Yong-Ping Lu, Bin Xia, Xiao-Hua Wang, Qiang-Sheng He, Chang-Bo Qu, Ying-Ying Xie, Tian-Jiao Cui, Si-Qing Wu, Jin-Yu Zhao, Zhi-Hua Zheng, Ting Zhu, Jin-Qiu Yuan, Chun Tang

“…Methods Data from the UK Biobank cohort, which included over 500,000 participants aged 40–69 from diverse regions of England, Wales, and Scotland, were analyzed. Participants, who completed at least one online 24-hour dietary recall assessment, were included in the study. …”
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Adverse Effects of Intraparenchymal and Peritumoral Application of Isosulfan Blue Dye in Sentinel Lymph Node Mapping in Breast Cancer: A Systematic Review and Meta-Analysis by Joshua Agilinko, Aditya Borakati, Andrel Yoong, Ponnuthurai Pratheepan, Suzette Samlalsingh

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Evaluating reproduction traits in a crossbreeding program between indigenous and exotic sheep in semi-arid lands by E. Oyieng, J.M.K. Ojango, M. Gauly, R. Mrode, R. Dooso, A.M. Okeyo, C. Kalinda, S. König

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Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks by Fiona Greco, Hannah M. Ravenswater, Francisco Ruiz-Raya, Chiara D’Avino, Mark A. Newell, Josie Hewitt, Erin Taylor, Ella Benninghaus, Francis Daunt, Gidona Goodman, David Steel, Jenny Park, Emma Philip, Saumya S. Thomas, Marek J. Slomka, Marco Falchieri, Scott M. Reid, Joe James, Ashley C. Banyard, Sarah J. Burthe, Emma J. A. Cunningham

“…We therefore tested for antibodies, indicative of previous exposure and recovery, and for active viral infection in apparently healthy individuals (n = 350) across five co-occurring seabird species on the Isle of May, Scotland, during 2023, following H5N1 HPAIV associated mortality in the preceding summer. …”
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Laser interaction with undercritical foams of different spatial structures by J. Limpouch, V. Tikhonchuk, O. Renner, Sh. Agarwal, T. Burian, J. Červenka, J. Dostál, R. Dudžák, D. Ettel, A. Gintrand, L. Hudec, L. Juha, O. Klimo, M. Krupka, M. Krus, T. Lastovicka, R. Liska, W. Nazarov, S. K. Singh, M. Šilhavík, S. Weber

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Blood-based epigenome-wide association study and prediction of alcohol consumption by Elena Bernabeu, Aleksandra D. Chybowska, Jacob K. Kresovich, Matthew Suderman, Daniel L. McCartney, Robert F. Hillary, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Zongli Xu, Dale P. Sandler, Archie Campbell, Sarah E. Harris, Andrew M. McIntosh, Jack A. Taylor, Paul Yousefi, Simon R. Cox, Kathryn L. Evans, Matthew R. Robinson, Catalina A. Vallejos, Riccardo E. Marioni

“…Here, we explore the epigenetic architecture of self-reported weekly units of alcohol consumption in the Generation Scotland study. We first create a blood-based epigenetic score (EpiScore) of alcohol consumption using elastic net penalized linear regression. …”
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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar by John Norrie, Julie Woodfield, David J Lowe, Paul M Brennan, Catriona Keerie, Julia Lawton, Matthew J Reed, Andrew Stoddart, Julia Boyd, Helen Eborall, Gina Cranswick, James Tomlinson, Polly L Black, Sadaquate Khan, Patrick Statham, Ellie Edlmann, Phillip Correia Copley, Angela Niven, Susan Deborah Shenkin

“…The DENS trial received a favourable ethical opinion from the Scotland A Research Ethics Committee (21/SS/0036) and the Leeds West Research Ethics Committee (21/YH/0141).Trial registration number NCT04895644.…”
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FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis by David Hunt, Siddharthan Chandran, Peter Connick, Peter Foley, Patrick K A Kearns, Sergio E Baranzini, Adam D Waldman, Sarah J Martin, Elizabeth Freyer, F J Carod-Artal, Lee Murphy, Amy Stenson, Jessie Chang, Rozanna Meijboom, Elizabeth N York, Yingdi Chen, Christine Weaver, Katarzyna Hafezi, Stacey Thomson, Adil Harroud, Margaret McLeod, Jonathon O'Riordan, Niall J J MacDougall

“…There is, therefore, a need for integrated predictive tools to inform individualised treatment decision making.Participants Established with the aim of addressing this need for individualised predictive tools, FutureMS is a nationally representative, prospective observational cohort study of 440 adults with a new diagnosis of relapsing-remitting MS living in Scotland at the time of diagnosis between May 2016 and March 2019.Findings to date The study aims to explore the pathobiology and determinants of disease heterogeneity in MS and combines detailed clinical phenotyping with imaging, genetic and biomarker metrics of disease activity and progression. …”
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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

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Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…Using this novel trial design reduces time, cost and number of participants required to definitively (phase III) evaluate drugs and reduces exposure of participants to potentially ineffective treatments.Ethics and dissemination MND-SMART was approved by the West of Scotland Research Ethics Committee on 2 October 2019. …”
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