Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

“…However, in recent decades, its role in the adult brain has become increasingly important, and it is now clear that diminished Reelin function is involved in the pathogenesis and progression of neuropsychiatric and neurodegenerative disorders, including schizophrenia and Alzheimer’s disease (AD). Reelin activity is regulated at multiple steps, including synthesis, posttranslational modification, secretion, oligomerization, proteolytic processing, and interactions with extracellular molecules. …”
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Inflammatory Fibroid Polyp in a 48-Year-Old Male: A Rare Cause of Intussusception by Theresia Karuhanga, Caroline Ngimba, James J. Yahaya

“…Herein, we present a case of a 48-year-old male with a known history of schizophrenia who presented with mechanical intestinal obstruction following intussusception due to inflammatory fibroid polyp involving the proximal jejunojejunal part of the jejunum.…”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

“…Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. …”
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Assessing the health implications of anticholinergic drugs in older people by Mariangela Boccardi, Virginia Boccardi

“…We propose practical guidelines for their use in clinical contexts such as dementia, schizophrenia, depression, anxiety, Parkinson’s disease, cardiovascular conditions, and urinary incontinence. …”
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Constrictive Pericarditis Associated with Atypical Antipsychotics by Kuan-chin Jean Chen, Aashish Goela, Patrick Teefy, L. Ray Guo

“…Pericarditis developed in our patient with a longstanding history of schizophrenia treated with atypical antipsychotics. Pericardiectomy was undertaken, and the patient's presenting symptom of shortness of breath resolved subsequently with an uneventful postoperative course.…”
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Pharma TARP: A Troubled Asset Relief Program for Novel, Abandoned Projects in the Pharmaceutical Industry by Tamas Bartfai, Graham Vaughan Lees

“…Society has a real need for the drugs that are no longer going to be developed for, among others, drug-resistant epilepsy, neuropathic and cancer pain, type-2 diabetes, obesity, and schizophrenia. The authors propose a radical response by the U.S. government and the National Institutes of Health to rescue these abandoned projects, and to continue selected programs for drug approval by the U.S. …”
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P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…The findings discussed here may explain how P2Y1 receptor activation during brain injury, hypoxia, inflammation, schizophrenia, or Alzheimer’s disease leads to an impairment of cognitive processes. …”
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Clozapine-Induced Myocarditis: Is Mandatory Monitoring Warranted for Its Early Recognition? by T. A. Munshi, D. Volochniouk, T. Hassan, N. Mazhar

“…Clozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. …”
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Comprehensive synthesis of mHealth interventions in psychiatry: insights from systematic, scoping, narrative reviews and content analysis by Zaakira Shahul Hameed Mahreen, Noor Azziah Zainuldin, Melvyn Weibin Zhang

“…Additionally, mHealth shows promise in managing substance use disorders and severe mental illnesses like schizophrenia, bipolar disorder and psychosis. Conclusion: Despite positive outcomes, challenges such as data privacy, user engagement and healthcare integration persist. …”
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Thiamine Deficiency in Self-Induced Refeeding Syndrome, an Undetected and Potentially Lethal Condition by Einat Hershkowitz, Alon Reshef, Olga Munich, Bracha Yosefi, Arie Markel

“…We describe a 25-years-old female patient with mental disorders and severe malnutrition who developed severe clinical manifestations and biochemical abnormalities characteristic of the refeeding syndrome, after restarting oral feeding on her own. Schizophrenia was later diagnosed. Increased awareness of this condition and its complications is necessary to prevent its detrimental complications.…”
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Cooccurrence of Darier’s Disease and Epilepsy: A Pediatric Case Report and Review of the Literature by Tamer Celik, Umit Celik, Cigdem Donmezer, Mustafa Komur, Orkun Tolunay, Pelin Demirtürk

“…They include mood disorders, epilepsy, encephalopathy, and schizophrenia. In this study, we report a pediatric case with the cooccurrence of Darier’s disease and epilepsy. …”
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A multidimensional assessment of adverse events associated with paliperidone palmitate: a real-world pharmacovigilance study using the FAERS and JADER databases by Siyu Lou, Zhiwei Cui, Yingyong Ou, Junyou Chen, Linmei Zhou, Ruizhen Zhao, Chengyu Zhu, Li Wang, Zhu Wu, Fan Zou

“…Common ADEs included increased blood prolactin, galactorrhea, and schizophrenia, which was consistent with drug label. …”
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Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. by Alvin Richards-Belle, Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Al Richards, Kenneth K C Man, Neil M Davies, Elvira Bramon, Joseph F Hayes, David P J Osborn

“…., bipolar disorder, schizophrenia, and other non-organic psychoses) who were prescribed a new antipsychotic between 2005 and 2017, with a 2-year follow-up to 2019. …”
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A 27-Month-Old Boy with Polyuria and Polydipsia by Yvonne Lee, Erica Winnicki, Lavjay Butani, Stephanie Nguyen

“…Psychogenic polydipsia is a well-described phenomenon in those with a diagnosed psychiatric disorder such as schizophrenia and anxiety disorders. Primary polydipsia is differentiated from psychogenic polydipsia by the lack of a clear psychotic disturbance. …”
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Emerging Roles of BAI Adhesion-GPCRs in Synapse Development and Plasticity by Joseph G. Duman, Yen-Kuei Tu, Kimberley F. Tolias

“…Abnormalities in synapse and spine formation and plasticity are associated with a broad range of brain disorders, including intellectual disabilities, autism spectrum disorders (ASD), and schizophrenia. Thus, elucidating the mechanisms that regulate these neuronal processes is critical for understanding brain function and disease. …”
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Microglial Dysregulation in Psychiatric Disease by Luciana Romina Frick, Kyle Williams, Christopher Pittenger

“…Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. …”
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Lessons Learned and Questions Raised by an Atypical Case of Clozapine-Induced Myocarditis by Charles H. Earnshaw, Lucy Powell, Owen Haeney

“…A Caucasian male in his early twenties suffering from treatment resistant schizophrenia was started on clozapine. After three days he developed tachycardia, a common side effect of clozapine induction. …”
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The Value of Desmethylclozapine and Serum CRP in Clozapine Toxicity: A Case Report by Khalid Abou Farha, Andre van Vliet, Henderikus Knegtering, Richard Bruggeman

“…Clozapine, an atypical antipsychotic, has proved to be superior to other antipsychotics in treating patients with refractory schizophrenia. An increased plasma clozapine level above the therapeutic window may be associated with serious adverse events including paralytic ileus. …”
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Sword of heaven by Richard Wilson

“…If Shakespeare editions have been slow to absorb the news from Vienna that the schizophrenia of Measure for Measure is a result not of authorial despair, but of its having been constructed by two dramatists of distinct generations and mentalities, working some sixteen years apart, they have nonetheless always registered resistance in the play to this totalitarian project of putting power on display.…”
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Progress on neuromodulation for treatment of mental disorders by DONG Wen⁃wen, QIU Chang, ZHAO Liang, ZHANG Wen⁃bin

“…This paper summarizes the current applications of neuromodulation technique for various mental disorders, including obsessive⁃compulsive disorder, depression, Tourette's syndrome, bipolar affective disorder, autism spectrum disorder, substance dependence and schizophrenia. Additionally, it analyzes the prospects and challenges of neuromodulation technique in the treatment of mental disorders, with the aim of guiding future neuromodulation therapy for mental disorders.…”
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