SV40 Tag/p53 Complexes Actively Promote Malignant Cell Growth of Human Mesothelial Cells [1] by Maurizio Bocchetta, Michele Carbone

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The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients by Rehab M. Samaka, Hayam A. Aiad, Mona A. Kandil, Nancy Y. Asaad, Nanes S. Holah

“…The pathogenesis of lymphomas is not yet well understood. SV40 induces malignant transformation by the large T-antigen (L-TAG) and promotes transformation by binding and inactivating p53 and pRb. …”
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A study on the production of extracellular vesicles derived from novel immortalized human placental mesenchymal stromal cells by Yingying Tong, Jie Sun, Xin Jiang, Xu Jia, Huimin Xiao, Hua Wang, Guanghua Yang

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Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. by Lilli Stergiou, Manuel Bauer, Waltraud Mair, Damaris Bausch-Fluck, Nir Drayman, Bernd Wollscheid, Ariella Oppenheim, Lucas Pelkmans

“…Simian Virus 40 (SV40) is a paradigm pathogen with multivalent binding sites for the sphingolipid GM1, via which it induces its endocytosis for infection. …”
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Construction and function validation of inducible immortalized gene integration vectors by YUE Wei, YANG Yue, QIAN Baohua, LI Yanxin, GU Haihui

“…[Methods] Using gene homologous recombination technology, the coding sequences (CDS) of immortalization genes-including human telomerase reverse transcriptase (hTERT), simian virus 40 large T antigen (SV40LT), acute myeloid leukemia fusion genes NUP98-KDM5A (N/K) and CBFA2T3-GLIS2 (C/G), as well as the proto-oncogene KRAS were precisely inserted into the tetracycline (Tet)-inducible eukaryotic expression lentiviral vector pLV2-TRE3GS-EGFP-MCS-3×FLAG-hPGK-Tet-On-SV40-Neo and the transposon PB-TRE3G-3×FLAG-T2A-Puro-SV40-PA. …”
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Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles by Takeharu Watanabe, Masayuki Hayashi, Masaaki Arai, Sho Matsushita, Hiroshi Handa, Masaaki Kawano

“…In a previous study, we showed that administration of antigen-incorporated virus-like particles (VLPs) derived from simian virus 40 (SV40) induces production of cytotoxic T lymphocytes (CTL), as well as antibodies against the incorporated antigen(s), without the need for an adjuvant; however, it remains unclear how immune cells recognize and respond to the SV40 capsid because SV40 VLPs did not upregulate expression of maturation markers on dendritic cells. …”
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Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System by Serena Delbue, Manola Comar, Pasquale Ferrante

“…These viruses were originally isolated in mouse (mPyV) and in monkey (SV40). In 1971, the first human polyomaviruses BK and JC were isolated and subsequently demonstrated to be ubiquitous in the human population. …”
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Crack Risk Evaluation of Submerged Concrete Tunnel during Hardening Phase by G. M. Ji, T. Kanstad, Ø. Bjøntegaard

“…Five types of concrete mixes denoted as SV40, 40% BFS, 60% BFS, 40% FA, and 60% FA concrete are considered in the current study, and the measurement to reduce the initial temperature is also considered for 60% FA concrete. …”
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Artificial 64-Residue HIV-1 Enhancer-Binding Peptide Is a Potent Inhibitor of Viral Replication in HIV-1-Infected Cells by Mouhssin Oufir, Leslie R. Bisset, Stefan R. K. Hoffmann, Gongda Xue, Stephan Klauser, Bianca Bergamaschi, Alain Gervaix, Jürg Böni, Jörg Schüpbach, Bernd Gutte

“…An artificial HIV-1 enhancer-binding peptide was extended by nine consecutive arginine residues at the C-terminus and by the nuclear localization signal of SV40 large T antigen at the N-terminus. The resulting synthetic 64-residue peptide was found to bind to the two enhancers of the HIV-1 long terminal repeat, cross the plasma membrane and the nuclear envelope of human cells, and suppress the HIV-1 enhancer-controlled expression of a green fluorescent protein reporter gene. …”
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Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum morifolium Flower Extracts in Hepatocytes and Renal Glomerular Mesangial Cells by Po-Jung Tsai, Mei-Ling Chang, Ching-Mei Hsin, Chung-Chieh Chuang, Lu-Te Chuang, Wen-Huey Wu

“…The aim of this study was to investigate the protective effects of methanolic flower extracts of Osmanthus fragrans (OF) and Chrysanthemum morifolium (CM) against FFA-induced lipotoxicity in hepatocytes (human HepG2 cells) and renal glomerular mesangial cells (mouse SV40-Mes13 cells). The results showed that OF and CM significantly suppressed FFA-induced intracellular triacylglycerol accumulation via partially inhibiting the gene expression of sterol regulatory element-binding protein-1c (SREBP-1c) and glycerol-3-phosphate acyltransferase (GPAT) in HepG2 cells. …”
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Highly Proliferative Immortalized Human Dental Pulp Cells Retain the Odontogenic Phenotype when Combined with a Beta-Tricalcium Phosphate Scaffold and BMP2 by Xiangfen Li, Liu Wang, Qin Su, Ling Ye, Xuedong Zhou, Dongzhe Song, Dingming Huang

“…To overcome these challenges, we successfully immortalized human dental pulp cells using the piggyBac system which was employed to efficiently overexpress the SV40 T-Ag, and we then comprehensively described the cell biological behavior. …”
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A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms by I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin

“…One type of the cell lines contains an exogenous repeat integrated into the genome by the Sleeping Beauty transposon; in another cell line, the vector is maintained as an episome due to the SV40 origin of replication. These experimental systems can serve for f inding the causes of instability and the development of therapeutic agents. …”
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肝脏特异性可调控丙型肝炎病毒核心蛋白表达的转基因小鼠模型的建立 by 杨国柱, 傅思莹, 黄冰, 单于, 肖东, 马芸, 邓新燕, 陈系古

“…【方法】重组构建含有目的基因HCV-C、TRE序列和SV40polyA的转基因载体pTRE-HCV-C．以显微注射的方法将l_153kb的转基因片段注人BALB／C母鼠的受精卵．出生动物及其后代经PCR初步筛选出阳性．再经Southern杂交对阳性鼠基因组DNA标本行进一步鉴定。…”
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