circRNA18_46222157_46248185 inhibits melanogenesis by targeting miR-211/ pathway in goat melanocytes by Kai Yuan Ji, Xue Qing Zhang, Yi Wei Zhao, Chun E Liang, Xin Yuan, Yun Hai Zhang

“…Downregulation of EP300 expression in melanocytes through siRNA-EP300 transfection results in a substantial increase (p<0.05) in melanin production. qRT-PCR results indicated that overexpression of mimics-circRNA18 in melanocytes markedly suppressed (p<0.0001) miR-211 expression, significantly elevated (p<0.01) EP300 expression, and significantly inhibited (p<0.001) melanin production. …”
Get full text

Les capucins discriminent-ils les intentions d’autrui dans un contexte d’interactions interspécifiques ? by Elsa Llerena, Charlotte Canteloup, Helene Meunier

“…Dans cette étude, nous avons testé si les capucins bruns (Sapajus apella) et les capucins moines (Cebus capucinus) sont capables de percevoir les intentions d’un expérimentateur humain. …”
Get full text

Tangeretin alleviates sepsis-induced acute lung injury by inhibiting ferroptosis of macrophage via Nrf2 signaling pathway by Hui Zhang, Yan Wang, Shenghua Wang, Xiaomei Xue, Kai Huang, Dunfeng Xu, Lai Jiang, Siyuan Li, Yunqian Zhang

“…In vitro, RAW264.7 were treated with Nrf2 siRNA, the expression of ferroptosis-associated biomarkers, including glutathione peroxidase 4 (GPX4) and prostaglandin-endoperoxide synthase 2 (PTGS2) were assessed. …”
Get full text

Tolerance of pedunculate oak (Quercus robur) saplings to herbicides by Pablo Laclau, Natalia Murillo, B. Bértoli, Osvaldo Vignolio

“…Los modos de evadir la penetración de los herbicidas en el período invernal pueden relacionarse con la profundidad de las raíces, con la ausencia de hojas y con la protección de las yemas por pérulas; y en la primavera con la profundidad de las raíces, con el espesor de la cutícula y con la pilosidad foliar, y con la alta capacidad de rebrote de los robles. Si bien los resultados alcanzados son promisorios para la implantación de robles en sitios expuestos a herbicidas de uso corriente, es necesario conducir otros estudios para evaluar la reacción de las plantas a largo plazo, o sujetas a aplicaciones repetidas en el tiempo.…”
Get full text

Educación y ejemplaridad: cultivando un corazón educado by Javier Gomá Lanzón

“…En primer lugar, se discute la cuestión de si las personas consideradas vulgares pueden crear obras artísticas de calidad. …”
Get full text

Aplicación de métodos de virtualización en arqueología: el caso de la estela A de la tumba de Henenu (TT 313, Deir el-Bahari, Egipto) by Antonio J. Morales, Mario Ramírez Galán, Marina Camacho Galán, Flavio Celis D’Amico, Ernesto Echeverría Valiente

“…Una vez recuperados los datos arqueológicos y arquitectónicos, los especialistas del MKTP procedieron a reconstruir las posibles dimensiones de estas estelas mediante técnicas digitales. Además, se examinó si las estelas encajaban en los nichos originales construidos para este propósito. …”
Get full text

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

“…Mechanisms of uptake and cellular accumulation of eTau species were studied by using small molecule inhibitors of endocytic mechanisms and siRNAs targeting Tau uptake mediators. Results Extracellular Tau aggregates accumulated more than monomers in human neurons, mainly due to the higher efficiency of small fibrillar and soluble oligomeric aggregates in intraneuronal accumulation. …”
Get full text

The compensatory enrichment of sphingosine-1-phosphate on HDL in FSGS enhances the protective function of glomerular endothelial cells compared to MCD by Yunfeng Xiong, Qiuping Ye, Lifang Liu, Wanjun Lin, Yonggen Liao, Ruiyu Gao, Jiaming Xu, Xinyu Zhang, Ruoyan Chen, Sihui Chen, Qiaoling Chen, Lixin Wei

“…Knockdown of S1PR1 using siRNA reduced the expression of p-eNOS and NO release. …”
Get full text

Development of a phenomena identification and ranking table (PIRT) for intermediate break loss-of-coolant accident in PWRs by Hae Min Park, Jong Hyuk Lee, Chiwoong Choi, Kwi-Seok Ha, Byung Hyun You, Jaeseok Heo, Kyung Doo Kim, Sung Won Bae, Seung Wook Lee, Dong Hyuk Lee, Sang Ik Lee, Chan Eok Park, Bub Dong Chung, Kwang Won Seul

Get full text

Balancing water saving, market attractiveness, and pollution control in crop spatial planting structure planning of arid regions by Longbin Hao, Shouhong Zhang, Fan Zhang, Yufei Ren, Xinyu Zhang, Jing Yan

“…Results indicate that: (1) The grid-based 0–1 integer multi-objective approach can effectively make tradeoff among market attractiveness, pollution control, and crop suitability for crop planting structure planning in arid regions. (2) Optimal crop planting structure can increase agricultural planting profits by 4.679 billion CNY, while reduces system agricultural non-point source pollution and total water allocation by 34.72 % and 10.19 %, respectively. (3) The multi-objective approach shows better performance than single-objective models by comparing the Synthetic Degree (SD), Sustainability Index (SI), and Approximation Degree (AD). The advantages and successful application of proposed approach indicate that it is universality and effectiveness in addressing agricultural resource management issues in arid regions.…”
Get full text

Actividad de recubrimientos de quitosano, nanopartículas de quitosano y ZnO contra hongos aislados e identificados molecularmente de frutas con potencial de exportación en la zona... by Gerardo Juan Francisco Cruz, Rosa Liliana Solís-Castro, John Rimaycuna, José Luis Solís, Mónica Marcela Gómez, Rubén Alfaro

“…Se determinó que la concentración de NPs de quitosano no tuvo ningún efecto sobre la capacidad antifúngica de los recubrimientos, mientras que las NPs de ZnO si tuvieron un efecto directamente proporcional. …”
Get full text

Les macaques de Tonkéan (Macaca tonkeana) et les macaques rhésus (Macaca mulatta) discriminent-ils les mêmes indices sociaux d’un partenaire humain ? by Charlotte Canteloup, Dalila Bovet, Helene Meunier

“…Autrement dit, nous avons cherché à savoir si les macaques étaient capables d’utiliser ce geste en fonction de l’état d’attention du partenaire humain qu’il soit attentif ou inattentif. …”
Get full text

Rapid and specific on-site H5Nx avian influenza diagnosis via RPA and PAM-independent CRISPR-Cas12a assay combined with anti-NP antibody-based viral RNA purification by Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Seung-Ji Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Hyuk-Joon Kwon, Hyuk-Joon Kwon, Hyuk-Joon Kwon, Kang-Seuk Choi, Kang-Seuk Choi

Get full text

Un programme d’éducation à l’environnement en RDC : la malle pédagogique « les grands singes et leur habitat », présentation des résultats d’une campagne de sensibilisation en pays... by Louis Ledo, Jean Christophe Bokika Ngawolo, Samy Mankoto, Richard Dumez, Sabrina Krief

“…L’éducation à l’environnement en sensibilisant les populations locales à leurs rôles dans la conservation apparaît comme un moyen de protéger ces écosystèmes. Si les populations locales sont majoritairement dépendantes des ressources de cet écosystème (alimentation, construction, médecine, etc.), les usages et les menaces qui pèsent sur ces habitats varient en fonction des régions et des cultures. …”
Get full text

Selective phase growth of ultra-smooth Ti2O3 and TiO2 thin films at low growth temperature controlled by the oxygen partial pressure by Jiayi Tang, Okkyun Seo, Jaemyung Kim, Ibrahima Gueye, L.S.R. Kumara, Ho Jun Oh, Wan-Gil Jung, Won-Jin Moon, Yong Tae Kim, Satoshi Yasuno, Tappei Nishihara, Akifumi Matsuda, Osami Sakata

Get full text

DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment by Jeong Min Lee, Won Hyeok Lee, Seung Hyeon Cho, Jeong Woo Park, Hyuk Nam Kwon, Ji Hye Kim, Sang Hun Lee, Ji Hyung Yoon, Sungchan Park, Seong Cheol Kim

“…Cells were transfected with DRG2 siRNA, and pcDNA6/V5-DRG2 was used to overexpress DRG2. …”
Get full text

MicroRNA-99b-5p通过抑制成纤维细胞生长因子21表达促进心肌细胞肥大 by 陈丽文, 郭晶, 陈泽润, 朱杰宁, 徐金东, 郭惠明, 单志新, 王晟

“…利用腺病毒介导在NMVCs中过表达Fgf21及超氧化物歧化酶2（Sod2），并利用小干扰RNA（siRNA）敲低NMVCs中Fgf21和Sod2表达，研究Fgf21/Sod2轴是否介导miR-99b-5p对心肌细胞肥大表型的调节作用。…”
Get full text

Efecto de la fotobiomodulación vascular en el control de la ansiesad infantil en el cuidado odontológico. Ensayo clínico aleatorizado doble ciego by Elizabeth Grudzien, Magdalena San Martin, Laura Hermida, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Lara Motta Jansiski

“…FC disminuyo de 86 a 84 y de 93 a 86 l/s en el G1 y G0; aunque en G1 (p=0,333), la disminución no fue estadísticamente significativa, la caída en G0 sí fue significativa (p=0,001).  Conclusiones: No hubo diferencias estadísticamente significativas con el uso de fotobiomodulación  para controlar la ansiedad de los niños durante la atención odontológica en los grupos estudiados. …”
Get full text

High-performance 2D electronic devices enabled by strong and tough two-dimensional polymer with ultra-low dielectric constant by Qiyi Fang, Kongyang Yi, Tianshu Zhai, Shisong Luo, Chen-yang Lin, Qing Ai, Yifan Zhu, Boyu Zhang, Gustavo A. Alvarez, Yanjie Shao, Haolei Zhou, Guanhui Gao, Yifeng Liu, Rui Xu, Xiang Zhang, Yuzhe Wang, Xiaoyin Tian, Honghu Zhang, Yimo Han, Hanyu Zhu, Yuji Zhao, Zhiting Tian, Yu Zhong, Zheng Liu, Jun Lou

“…To address these challenges, new low-k dielectric (k < 2) materials need to be developed to replace current silicon dioxide (k = 3.9) or SiCOH, etc. However, existing low-k dielectric materials, such as organosilicate glass or polymeric dielectrics, suffer from poor thermal and mechanical properties. …”
Get full text

Ecological concrete by partially substitution of cement with Cameroonian corn stover ash by Martial Ngnihamye Nde, Seidou Youssoufa, Fabien Kenmogne, Merveille Meto Kuigne, Michel Mbessa, Emmanuel Yamb Bell, Didier Fokwa

“…The results of the chemical analyses carried out on the CCSA show that it contains 73.97 % of SiO2 + Al2O3 + Fe2O3, giving it a pozzolanic character in accordance with ASTM C618 standard. …”
Get full text