Design, synthesis, SAR and ADMET analyses of the novel class of synthetic 7-amino[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate derivatives with vasorelaxant activity by Anatolii Varenyk, Roman Vydzhak, Svitlana Panchishin, Irina Ivanova, Victor Zhirnov, Volodymyr Brovarets

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Tipificación morfológica de cursos principales. Cuenca del arroyo El Negro, Sistema de Ventania, Argentina by Alicia M. Campo, Verónica Gil, Guadalupe Ybarra Alcaráz, Antonela Volonté

“…La tipificación de estas formas permite clasificar y caracterizar un río para aportar información clave de cada uno de los tramos a lo largo del perfil longitudinal. Si bien existen varias clasificaciones y/o tipificaciones se seleccionó la propuesta por Rosgen (1994) que combina aspectos hidrológicos, geomorfológicos y ecológicos que sirven como indicadores de dicho funcionamiento. …”
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hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling by Mengbo Yang, Xinda Chen, Ming Zhang, Xiaolin Zhang, Dongdong Xiao, Huiming Xu, Mujun Lu

“…To explore the role of the SIRT1/PGC-1α/TFAM pathway in regulating mitochondrial biogenesis of CCSMCs, we knocked down SIRT1 by siRNA. Results The administration of hUC-MSC significantly improved erectile function of CNI-ED rats and reduced the ratio of collagen to smooth muscle. …”
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Hydrogen absorption kinetics and microstructural features of TiFe0.8Mn0.2 alloy by Ryun-Ho Kwak, Taeyang Kwak, Da Hye Lee, Sojin Jung, Jang-Won Kang, Seongtak Kim, Tae-Wook Na, Seok Su Sohn, Hyung-Ki Park, Taejun Ha

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Multiomics identify the gene expression signature of the spinal cord during aging process by Lintao Xu, Jingyu Wang, Jinjie Zhong, Weiwei Lin, Gerong Shen, Ning He, Xingjia Mao, Chunyan Fu, Zhaobo Huang, Fengdong Zhao, Xin Ye, Yongjian Zhu, Mingzhi Zheng, Hui Li, Lin-lin Wang, Kai Zhong, Lijun Zhu, Ying-ying Chen

“…Flow cytometry reveals increased accumulation of free Fe2+ and ROS in senescent mixed glial cells; however, CCK-8 assays reveal that these cells are resistant to ferroptosis. SiRNA and lentivirus experiments indicate that the overexpression of Fth1 in normal mixed glial cells reduces their sensitivity to ferroptosis, whereas Fth1 knockdown increases their sensitivity to ferroptosis. …”
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EFECTO DE LA CANTIDAD DE REPETICIONES MENTALES DIRIGIDAS DE LA TAREA SOBRE EL RENDIMIENTO DE UNA RUTINA OBLIGATORIA DE PISO EN NIÓAS QUE PRACTICAN GIMNASIA by Laura Sobalvarro Chavarría, Gerardo Araya Vargas

“…Se concluye que la práctica mental es más efectiva si se realiza mayor cantidad de repeticiones de la tarea antes de practicar físicamente. …”
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MEST Regulates the Stemness of Human Periodontal Ligament Stem Cells by Daigaku Hasegawa, Kana Hasegawa, Hiroshi Kaneko, Shinichiro Yoshida, Hiromi Mitarai, Mai Arima, Atsushi Tomokiyo, Sayuri Hamano, Hideki Sugii, Naohisa Wada, Tamotsu Kiyoshima, Hidefumi Maeda

“…MEST was expressed in the cytoplasm of 2-23 cells. Knockdown of MEST by siRNA in 2-23 cells inhibited the expression of stem cell markers, such as CD105, CD146, p75NTR, N-cadherin, and NANOG; the proliferative potential; and multidifferentiation capacity for osteoblasts, adipocytes, and chondrocytes. …”
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Soft skills en Enfermería by Yaneth Marcela Muñoz Angel

“…Al respecto, Kimberly Hires propuso cinco formas para ayudar a los millennials a desarrollar soft skills: predicar con el ejemplo, reconocer su potencial, incorporarse a su realidad, educar sin castigar y recordar que las soft skills son habilidades para la vida.4 Asimismo, en 2021, a través de una encuesta aplicada a los profesores de enfermería de los programas mejor clasificados en los Estados Unidos, Bajjaly y Saunders exploraron si los profesores enseñaban soft skills y cómo lo hacían. …”
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Relationship between Particulate Matter (PM10) and Airway Inflammation Measured with Exhaled Nitric Oxide Test in Seoul, Korea by Juwhan Choi, Jae Kyeom Sim, Jee Youn Oh, Young Seok Lee, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Ji-yong Moon, Kyung Hoon Min

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Business’ Attitudes Towards Corruption in Selected Central European Countries by Nenad Vretenar, Ana Marija Filipas, Martina Briš Alić

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Hybrid peptides inspired by the RWQWRWQWR sequence inhibit cervical cancer cells growth in vitro by Natalia Ardila-Chantré, Claudia Marcela Parra-Giraldo, Yerly Vargas-Casanova, Andrea Carolina Barragán-Cardenas, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Jhon Erick Rivera-Monroy, Javier Eduardo García-Castañeda

“…The cytotoxic effect exerted by the monomeric and dimeric hybrid peptides depended on the concentration of the peptide, which allowed the determination of the IC50 values and the selectivity index (SI). Conclusions: We obtained hybrid peptides with the core sequence RWQWRWQWR that are active against HeLa and Ca Ski cell lines. …”
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Evolution du comportement de manipulation chez les strepsirrhiniens by Louise Peckre, Anne‑Claire Fabre, Anthony Herrel, Christine Wall, Emmanuelle Pouydebat

“…Un effet important de la taille et de la consistance des items sur le choix du type de saisie est également mis en évidence. En effet, si une préférence significative pour les saisies avec la bouche est observée pour tous les autres items, les items grands et durs favorisent l’utilisation de la main. …”
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Aplicación de la teoría basada en los recursos en el Agroparque Ahualulco, S.A de C.V. by José Vargas-Hernández, Pablo Adrián Magaña Sánchez, Daniel Hernández-Medina

“…Derivado del análisis del excedente del consumidor podemos concluir que hay una demanda potencial alta y que el excedente del productor da el soporte para decir que dicha demanda si puede ser cubierta, lo anterior se puede lograr con reinversión apropiada de las utilidades, lo cual tendrá como resultado el crecimiento del negocio.…”
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The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection by Yu ZC, Fang ZK, Yu Y, Liu SY, Wang KD, Shi ZJ, Jin LM, Huang XK, Lu Y, Shen GL, Liu JW, Huang DS, Zhang CW, Liang L

“…Zi-Chen Yu,1,2 Zheng-Kang Fang,1,2 Yang Yu,3 Si-Yu Liu,4 Kai-Di Wang,1,5 Zhe-Jin Shi,1,5 Li-Ming Jin,1 Xiao-Kun Huang,1,2 Yi Lu,1 Guo-Liang Shen,1 Jun-Wei Liu,1 Dong-Sheng Huang,1 Cheng-Wu Zhang,1 Lei Liang1 1Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, General Surgery, Cancer Center, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 4Department of Laboratory Medicine, The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Zhejiang University Lishui Hospital, Lishui, Zhejiang, People’s Republic of China; 5Department of the second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Lei Liang, General Surgery, Cancer Center, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People’s Republic of China, Email liangl1992@hotmail.comBackground & Aims: Dual-phenotype hepatocellular carcinoma (DPHCC) is discernible from classical HCC (CHCC) in its morphology and is characterized by the co-expression of both CHCC and cholangiocyte markers. …”
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MicroRNA-122 protects against interferon-α-induced hepatic inflammatory response via the Janus kinase–signal transducer and activator of transcription pathway by Fanwei Liu, Bowen Liu, Shanshan Xu, Yinhua Ni, Xiaoli Liu

“…Furthermore, silencing IFIT1 via an siRNA elicited an inflammatory response, whereas IFIT1 overexpression ameliorated hepatic inflammation and fibrosis in a manner comparable to that induced by IFN-α treatment. …”
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SAVASTIES ĮGIJIMO BŪDAI. FOUCAULT IR BACHTINAS APIE GYVENIMO ESTETIZACIJĄ by Leszek Koczanowicz

“…Jo skepticizmas apima ne tik mokslinį teoretizavimą, bet ir estetinę kontempliaciją, o ši, jo požiūriu, taip pat neapsieina be objektyvacijos, taigi baigiasi tam tikru produktu, objektu, o ne savastimi. …”
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Rationally designed universal passivator for high-performance single-junction and tandem perovskite solar cells by Zuolin Zhang, Yinsu Feng, Jike Ding, Quanxing Ma, Hong Zhang, Jiajia Zhang, Mengjia Li, Taoran Geng, Wenhuan Gao, Yang Wang, Boxue Zhang, Thierry Pauporté, Jian-Xin Tang, Hongjian Chen, Jiangzhao Chen, Cong Chen

“…Moreover, by suppressing carrier recombination, the large-area modules with an aperture area of 32.144 cm2 and perovskite/Si tandem solar cells coupled with VBETS passivation deliver a PCE of 21.00% and 30.98%, respectively. …”
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Análisis espectral de nubes de sal originadas en las cercanías de la laguna de Mar Chiquita utilizando sensores remotos. by Diana Rodriguez, Silvana Carina Bolzi, Ines Velasco, Mónica Marino

“…Para cada uno de ellos se analiza la respuesta espectral en las bandas reflectivas y las temperaturas de brillo, en forma individual o combinada en índices. Si bien este estudio es de carácter exploratorio, los resultados obtenidos indican que ciertos índices usados en la literatura para identificar estas nubes no son aplicables en forma generalizada y es entonces necesario obtenerlos a nivel local. …”
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Assessment of Chaves Low-Temperature CO2-Rich Geothermal System (N-Portugal) Using an Interdisciplinary Geosciences Approach by J. M. Marques, P. M. Carreira, L. A. Aires-Barros, F. A. Monteiro Santos, M. Antunes da Silva, P. Represas

“…Free CO2 is of about 500 mg/L. The results of SiO2 and K2/Mg geothermometers give estimations of reservoir temperature around 120°C. δ18O and δ2H values of Chaves low-temperature CO2-rich geothermal waters indicate a meteoric origin for these waters. …”
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Détermination du statut du Chimpanzé, Pan troglodytes verus, dans une zone non protégée de savane boisée à Bagnomba, Sénégal : Implication pour sa conservation by Papa Ibnou Ndiaye, Landing Badji, Stacy Marie Lindshield, Cheikh Tidiane Bâ, Jill Pruetz

“…Les particularités écologiques des habitats du chimpanzé dans cette zone (relief, végétation, disponibilité d’aliments, entre autres) associées à leur caractère sacré par les populations locales constituent des atouts qui favoriseraient la conservation des chimpanzés dans cette zone si des mesures idoines de protection étaient prises. …”
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