Estimating the impact of school closures on the COVID-19 dynamics in 74 countries: A modelling analysis. by Romain Ragonnet, Angus E Hughes, David S Shipman, Michael T Meehan, Alec S Henderson, Guillaume Briffoteaux, Nouredine Melab, Daniel Tuyttens, Emma S McBryde, James M Trauer

“…We compared the simulated epidemics in terms of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections, deaths, and hospital occupancy pressure. …”
Get full text

H3K4 methylation regulates development, DNA repair, and virulence in Mucorales by Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre

“…Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses a significant threat to human health due to its high mortality rate and its recent association with SARS-CoV-2 infections. On the other hand, histone methylation is a regulatory mechanism with pleiotropic effects, including the virulence of several pathogenic fungi. …”
Get full text

Experiencia de la superación profesional de los Enfermeros intensivistas para enfrentar la COVID 19. Cienfuegos. by Yanet Rojas Rodríguez, Lázaro Roberto Herrera Fragoso, Vladimir Barcos Díaz, Juan Carlos Alvarado Peruyero, Osmani Becerra Peña, Yunia Araña Hernández

“…<br /><strong>Conclusiones:</strong> la superación realizada permitió perfeccionar habilidades, usando como medio de enseñanza los simuladores para que los cursistas aplicaran las acciones específicas de bioseguridad y los cuidados en la atención integral al paciente con SARS/ CoV 2 sometido a ventilación mecánica artificial.…”
Get full text

Tuberculosis healthcare service disruptions during the COVID-19 pandemic in Brazil, India and South Africa: A model-based analysis of country-level data. by Abigail K de Villiers, Muhammad Osman, Claudio J Struchiner, Anete Trajman, Dheeraj Tumu, Vaibhav V Shah, Guilherme L Werneck, Layana C Alves, Megha Choudhary, Sunita Verma, Sanjay K Mattoo, Sue-Ann Meehan, Urvashi B Singh, Anneke C Hesseling, Florian M Marx

“…In recent years, stringent measures to contain the spread of SARS-CoV-2 have led to considerable disruptions of healthcare services for TB in many countries. …”
Get full text

The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients by Basma A. Yasseen, Aya A. Elkhodiry, Hajar El-sayed, Mona Zidan, Azza G. Kamel, Mohamed A. Badawy, Marwa S. Hamza, Riem M. El-Messiery, Mohamed El Ansary, Engy A. Abdel-Rahman, Engy A. Abdel-Rahman, Sameh S. Ali

“…Metabolic analysis of different blood cells revealed increased glycolytic activity only when considering the total number of neutrophils.ConclusionThis indicates the role of neutrophilia in hyperlactatemia and lung damage, subsequently contributing to mortality outcomes in severe SARS-CoV-2 infection.…”
Get full text

Vaccination against COVID-19 in patients with allergy: experience of the allergological center in Dnipro by Ye.M. Dytiatkovska, K.Yu. Gashynova, Ye.V. Korietskaia, M.A. Yevtushenko

“…Vaccination against COVID-19 is the main global preventive measure in the fight against SARS-CoV-2. As the COVID-19 vaccine will be administered to billions of individuals worldwide during the pandemic, there exists a reasonable fear of severe adverse reactions requiring constant vigilance and careful treatment, particularly in individuals with a history of severe allergy. …”
Get full text

Urban and Rural Differences in Cancer Treatment Disruption Among Patients With COVID‐19: An Analysis of the US ASCO COVID‐19 in Oncology Registry by Yu Chen Lin, Kea Turner, Oliver T. Nguyen, Emma Hume, Marlene Camacho‐Rivera, Jessica Y. Islam

“…Methods We used data from the American Society of Clinical Oncology Survey on COVID‐19 in Oncology Registry (March 2020–September 2022), which included cancer patients with test‐confirmed SARS‐CoV‐2 infection (N = 3797). Data included patient sociodemographic characteristics, COVID‐19 diagnosis information, cancer clinical characteristics, and changes to cancer treatment. …”
Get full text

Caracterización clínico-epidemiológica de la COVID 19. Centro de aislamiento MICONS. Cienfuegos, 2021 by Juan Rafael Zerquera Rodriguez, Livan Rojas Lantigua, Bárbaro Orlando Pérez Sabina, César Coma García, Keyla Zerquera Rodríguez

“…<br /><strong>Resultados</strong>: predominó el grupo de edades entre 45 a 59 años con el 33,8 %; el 48,4 % de pacientes ingresados en el centro fueron hipertensos; el 23,4 % del total de casos fueron positivos al virus SARS-CoV- 2; los síntomas predominantes fueron la fiebre con un 39,2 %; la tos con un 37,7 % y la cefalea con un 30,1 %. …”
Get full text

Manifestaciones neurológicas y psicológicas en pacientes pediátricos convalecientes de la COVID-19 by Jenrry Alvarez Cruz, Amaya Blanco del Frade, Mara Carassou Gutiérez, Liuba Luisa Arteche Hidalgo, Yanet Romero Reinaldo, Clara Ligia Santamaria Trujillo

“…Introducción: La capacidad de SARS-CoV-2 de producir manifestaciones neurológicas y psicológicas es indudable, aunque no son, a primera vista, diferenciables de las originadas por otras infecciones víricas. …”
Get full text

‘Communication, that is the key’: a qualitative investigation of how essential workers with COVID-19 responded to public health information by Yanbing Chen, Claire Buckley, Elizabeth Alvarez, Conor Buggy, Mark Roe, Mary Codd, Anne Drummond, Carolyn Ingram, Penpatra Sripaiboonkij, Carla Perrotta, Mary Archibald, Vicky Downey, Natalia Rachwal

“…Objectives To understand how essential workers with confirmed infections responded to information on COVID-19.Design Qualitative analysis of semistructured interviews conducted in collaboration with the national contact tracing management programme in Ireland.Setting Semistructured interviews conducted via telephone and Zoom Meetings.Participants 18 people in Ireland with laboratory confirmed SARS-CoV-2 infections using real-time PCR testing of oropharyngeal and nasopharyngeal swabs. …”
Get full text

Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials by Jingyun Yang, Weiqi Hong, Huashan Shi, Cai He, Hong Lei, Yanan Zhou, Hao Yang, Aqu Alu, Zimin Chen, Yun Yang, Wenhai Yu, Cong Tang, Junbin Wang, Bai Li, Qing Huang, Jiong Li, Li Yang, Wei Wang, Guobo Shen, Jinliang Yang, Zhiwei Zhao, Xiangrong Song, Zhaoming Su, Yuquan Wei, Qiangming Sun, Shuaiyao Lu, Zhenling Wang, Youchun Wang, Guangwen Lu, Weimin Li, Xiawei Wei

“…Tri-Vac demonstrates immunogenicity in female NIH mice, inducing cross-neutralization against various SARS-CoV-2 variants, including pre-Omicron and Omicron BA.2.75, BA.5, and XBB lineages. …”
Get full text

Immunisation schedule of the Pediatric Spanish Association: 2024 recommendations by Francisco José Álvarez García, Antonio Iofrío de Arce, Javier Álvarez Aldeán, Elisa Garrote Llanos, Lucía López Granados, María Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Ignacio Salamanca de la Cueva, Pepe Serrano Marchuet, Francisco José Álvarez García, Antonio Iofrío de Arce, Javier Álvarez Aldeán, María Garcés-Sánchez, Elisa Garrote Llanos, Abián Montesdeoca Melián, María Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Pepe Serrano Marchuet

“…AA.) usan tetravírica para las segundas dosis de triple vírica y varicela, recomendamos, para todas las CC.AA., adelantar la segunda dosis de vacuna frente a varicela a los dos años.Debido al muy importante aumento de casos de tosferina desde finales del 2023 y especialmente en 2024, recomendamos adelantar la dosis de Tdpa en la adolescencia a los 10-12 años.Para completar la protección frente a los meningococos en la adolescencia, recomendamos la vacunación frente al MenB a los 12 años.Consideramos que la vacunación frente a gripe debe ser sistemática hasta los 18 años, pero dadas las decepcionantes coberturas en los niños entre 6–59 meses, creemos prioritario actualmente aumentar dichas coberturas, y una vez conseguido este objetivo, ampliar la vacunación a niños y adolescentes entre 5–18 años.Se mantienen respecto al calendario 2024, entre otras, las tablas de inmunización sistemática para personas sanas y la de grupos de riesgo, el uso de las nuevas vacunas conjugadas de valencia ampliada frente al neumococo, la vacunación sistemática a los 4 meses de edad con MenACWY, y la vacunación frente al SARS-CoV-2 para personas mayores de 6 meses con factores de riesgo.…”
Get full text

A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

“…Here, we use single-molecule magnetic tweezers to reveal a concerted catalysis mechanism of mechanical conformational selection for a mini hammerhead ribozyme against a viral RNA sequence from the SARS-CoV-2. We identify a conformational set containing five mechanical conformers of the mini ribozyme, where magnesium ions select the active one. …”
Get full text

History of coronary heart disease increased the mortality rate of patients with COVID-19: a nested case–control study by Yaping He, Lei Xu, Tian Gu, Qiao Chu, Zhangsheng Yu, Botao Fa, Anqi Li, Ruijun Wu

“…Objective Evaluate the risk of pre-existing comorbidities on COVID-19 mortality, and provide clinical suggestions accordingly.Setting A nested case–control design using confirmed case reports released from the news or the national/provincial/municipal health commissions of China between 18 December 2019 and 8 March 2020.Participants Patients with confirmed SARS-CoV-2 infection, excluding asymptomatic patients, in mainland China outside of Hubei Province.Outcome measures Patient demographics, survival time and status, and history of comorbidities.Method A total of 94 publicly reported deaths in locations outside of Hubei Province, mainland China, were included as cases. …”
Get full text

High Quality–Factor All–Dielectric Metacavity for Label–Free Biosensing by Yuqiao Zheng, Jiacheng Sun, Yaqing Ma, Hongyong Zhang, Zhen Cui, Giannis G. Paschos, Xixi Song, Ying Tao, Pavlos Savvidis, Wei Kong, Liaoyong Wen, Sumin Bian, Mohamad Sawan

“…Moreover, the metacavity biosensor achieves high surface sensitivity, together with a detection‐limit of 119 viral copies mL−1 for label‐free severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pseudovirus sensing, revealing remarkable performance in both bulk and surface sensing.…”
Get full text

Microbial biotechnology alchemy: Transforming bacterial cellulose into sensing disease- A review by Ali Jawad Akki, Pratheek Jain, Ravindra Kulkarni, Raghavendra Rao Badkillaya, Raghavendra V. Kulkarni, Farhan Zameer, V Raghu Anjanapura, Tejraj M. Aminabhavi

“…The review covers various bacterial cellulose (BC)-based biosensors, from SARS-CoV-2 detection to wearable health monitoring and interaction with human-computer interfaces. …”
Get full text

Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact [version 3; peer review: 2 approved] by Ghadhoune Hatem, Yosra Yahia, Olfa Hammami, Hend Allouche, Insaf Trabelsi, Jihene Guissouma, Hana Ben Ali

“…Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mainly affects the respiratory tract, but different organs may be involved including the kidney. …”
Get full text

Clinical characteristics and outcomes of children with COVID-19 in pediatric intensive care units during the Omicron wave in Taiwan by Jeng-Hung Wu, Ching-Chia Wang, Frank Leigh Lu, Shu-Chien Huang, Ting-Yu Yen, Chun-Yi Lu, Luan-Yin Chang, En-Ting Wu

“…Background: Since April 2022, the SARS-CoV-2 Omicron variant has caused a notable increase in pediatric COVID-19 cases in Taiwan. …”
Get full text

Comprehensive analyses of immune activity in COVID-19-vaccinated idiopathic pulmonary fibrosis patients by Agata Maciejewska, Piotr Czernia, Magdalena Piotrowska-Mieczkowska, Beata Wajda, Bartosz Słomiński, Jan Romantowski, Adam Sudoł, Małgorzata Dąbrowska, Lucyna Górska, Tomasz Smiatacz, Marek Niedoszytko, Ewa Jassem, Maria Skrzypkowska, Piotr Trzonkowski

“…IPF patients without prior exposure to SARS-CoV-2 had undetectable levels of anti-N IgG antibodies, highlighting their lack of previous infection. …”
Get full text

Intervenciones parentales para el desarrollo lingüístico-comunicativo en preescolares con Trastornos del Neurodesarrollo: una revisión sistemática by Nicole B. Vargas, María-José Godoy, Isidora Jeraldo, Estefanía Orellana, Ingeborg Poblete, Sofia Riveros, Katherine Silva, Anthony Marcotti

“… En el actual escenario sociosanitario enfrentado a raíz de la pandemia por SARS-CoV-2, múltiples actividades se han visto mermadas, e incluso, suspendidas por los largos periodos de aislamiento social y las medidas de cuidado para evitar contagios. …”
Get full text