Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study by Xiaoying Cai, Xiaotian Xu, Aiwu Zhang, Jianwen Lin, Xiaojuan Wang, Wen He, Yannan Fang

“…Age and education were the independent risk factors of cognitive decline (P<0.05). After adjusting, the risk of cognitive decline was higher in CM compared with control in ACE-R score and language fluency (P<0.05). …”
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Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients by Francesco Giudici, Tiziana Cavalli, Cristina Luceri, Edda Russo, Daniela Zambonin, Stefano Scaringi, Ferdinando Ficari, Marilena Fazi, Amedeo Amedei, Francesco Tonelli, Cecilia Malentacchi

“…Methods. 191 surgical CD patients were prospectively characterized both for the main single nucleotide polymorphisms of CARD15/NOD2 and for many other environmental risk factors connected with the severe disease form. …”
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Primary results from the Japanese Heart Failure and Sudden Cardiac Death Prevention Trial (HINODE) by Kazutaka Aonuma, Kenji Ando, Kengo Kusano, Toru Asai, Koichi Inoue, Yukihiro Inamura, Takanori Ikeda, Takeshi Mitsuhashi, Toyoaki Murohara, Nobuhiro Nishii, Akihiko Nogami, Wataru Shimizu, Caroline Beaudoint, Torri Simon, Torsten Kayser, Hussin Azlan, Ngarmukos Tachapong, Joseph Yat‐Sun Chan, Valentina Kutyifa, Yasushi Sakata, For the HINODE Investigators

“…Cohorts 1–3 required a left ventricular ejection fraction ≤35%, a history of heart failure, and a need for primary prevention of sudden cardiac death based on two to five previously identified risk factors. Endpoint outcomes were adjudicated by the independent committees. …”
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High prevalence of overweight/obesity and central obesity among women in a rural district of Nepal in 2012–2013: a population-based study by Chandra Yogal, Chandra Yogal, Astrid Kamilla Stunes, Astrid Kamilla Stunes, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Mats P. Mosti, Mats P. Mosti, Miriam K. Gustafsson, Miriam K. Gustafsson, Bjørn Olav Åsvold, Bjørn Olav Åsvold, Berit Schei, Unni Syversen, Unni Syversen

“…We aimed to estimate the prevalence of overweight/obesity and central obesity, and associated risk factors among women in a rural setting of Nepal.MethodsA cross-sectional study addressing reproductive health and non-communicable diseases (NCDs) was conducted 2012–2013 in a rural district of Nepal. …”
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Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population by Chen Chen, Hanzhang Wu, Hanzhang Wu, Hongyu Jin, Zhiping Jiang, Wei Wang, Xiao Tan, Xiao Tan, Wen-Yang Li

“…Cox proportional hazards model was conducted to evaluate the association between sleep patterns or OBS alone and combined with all-cause and CVD mortality.ResultsPoor sleep patterns and pro-oxidant OBS (Q1 &amp; Q2) were identified as risk factors for mortality. Each point increase in OBS was associated with a 3% decrease in both all-cause mortality and CVD mortality. …”
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New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

“…In a 4-tier model, median OS for patients with 0–1, 2, 3–4 and 5–7 risk factors was 18.6, 10.4, 4.8 and 2.1 months, respectively. …”
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Posttraumatic Stress Disorder Is Associated With Endothelial Dysfunction in Women With HIV by Nishant Vatsa, MD, Alireza Rahbar, MD, Tanveer Kauser, MPH, Ariel Kirksey, BS, Daniel A. Gold, MD, Vardhmaan Jain, MD, Matthew E. Gold, MD, Heqiong Wang, MD, MPH, Christina Mehta, PhD, MSPH, Caitlin A. Moran, MD, Alicia K. Smith, PhD, Kimbi Hagen, EdD, Med, Ighovwerha Ofotokun, MD, MSc, Cecile D. Lahiri, MD, MS, Laurence Sperling, MD, Viola Vaccarino, MD, PhD, Puja K. Mehta, MD, Arshed A. Quyyumi, MD, Gretchen N. Neigh, PhD, Vasiliki Michopoulos, PhD

“…The impact of PTSD, HIV, and their interaction on endothelial function was evaluated using linear regression models adjusted for demographics, CVD risk factors, depressive symptoms, and statin use. Results: Overall, 55 (63.2%) had HIV, 24 (27.5%) had PTSD, and 13 (14.9%) had both. …”
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The association between serum ferritin levels and the risk of gestational diabetes mellitus: a prospective cohort study by Shaofei Su, Shen Gao, Enjie Zhang, Jianhui Liu, Shuanghua Xie, Yue Zhang, Ruixia Liu, Wentao Yue, Chenghong Yin

“…Conclusions Changes in serum ferritin levels are independent risk factors for GDM. These findings underscore the importance of maintaining iron metabolism at an appropriate level during early to mid-pregnancy to reduce the risk of developing GDM.…”
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A preliminary investigation into self-compassion and compassion-based intervention for mental health in the performing arts by Courtney C. Walton, James N. Kirby, Sabrina McKenzie, Sabrina McKenzie, Caroline X. Gao, Caroline X. Gao, Rosemary Purcell, Rosemary Purcell, Simon M. Rice, Simon M. Rice, Margaret S. Osborne, Margaret S. Osborne

“…Descriptive pre-post data combined with thematic analysis of semi-structured interview transcripts identified performer perspectives of the compassion-based intervention.ResultsIn Study 1, 211 participants were included in the final cross-sectional analysis, which showed that the intention to be self-compassionate was associated with lower symptoms of depression and anxiety, and higher wellbeing, even while controlling for several key demographic and risk factors (stress, alcohol use, and body appreciation). …”
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Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei by Ruiqing Ma, Guojun Li, Yingjiang Ye, Lei Liang, Chong Wang, Haipeng Zhou, Pu Zhang, Lubiao An, Guanjun Shi, Qian Chen, Hongbin Xu, Zhidong Gao

“…The p53 and TGF-β signaling pathways may contribute as risk factors for worse OS and PFS, respectively. MUC16-mutated patients had worse PFS (P = 0.016) and OS (P = 0.004) compared to wild-type patients. …”
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Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction by Irene López-Ferreruela, Sara Malo, Blanca Obón-Azuara, María José Rabanaque, Adriana Gamba, Sara Castel-Feced, Isabel Aguilar-Palacio

“…Methods A population-based observational study of RWD was conducted in the CARhES (CArdiovascular Risk factors for hEalth Services research) cohort. The study included subjects who had experienced a first episode of AMI between 2017 and 2022, had survived the event, and had a minimum follow-up of 180 days. …”
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Tracking Persistent Symptoms in Scotland (TraPSS): a longitudinal prospective cohort study of COVID-19 recovery after mild acute infection by Jane Ormerod, Nicholas F Sculthorpe, Marie McLaughlin, Luke Cerexhe, Eilidh Macdonald, Antonio Dello Iacono, Nilihan E M Sanal-Hayes, Joanne Ingram, Rachel Meach, David Carless, Lawrence D Hayes

“…Further analysis is required to determine the characteristics of the individuals still reporting ongoing symptoms months after initial infection to identify risk factors and potential predictors for the development of Long-COVID.…”
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Inflammatory biomarkers of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in 563 severe OSA patients before and after surgery by Chung-Wei Lin, Pei-Wen Lin, Li-Wen Chiu, Han-Tan Chai, Chun-Tuan Chang, Michael Friedman, Anna M. Salapatas, Sara Rahavi-Ezabadi, Hsin-Ching Lin

“…Abstract Background Evidence has proved that high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were risk factors for cardiovascular comorbidities. The alterations of NLR and PLR following obstructive sleep apnea (OSA) treatment were under studied and thus should be investigated. …”
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Predictors of chronic pain and level of physical function in total knee arthroplasty: a protocol for a systematic review and meta-analysis by Jens Ivar Brox, Christopher James Rose, Anners Lerdal, Øystein Skare, Unni Olsen, Maren Falch Lindberg, Eva Marie-Louise Denison, Caryl Lynn Gay, Arild Aamodt, Ove Furnes, Kathryn A Lee

“…Introduction One in five patients undergoing total knee arthroplasty (TKA) experience unchanged or worse pain and physical function 1 year after surgery. Identifying risk factors for unfavourable outcomes is necessary to develop tailored interventions to minimise risk. …”
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Protocol of the Nurses’ Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study by Jiaxin Yang, Chongmei Huang, Shuiyuan Xiao, Xuting Li, Meng Ning, Zengyu Chen, Yusheng Tian, Qiang Yu, Yamin Chen, Ya-Min Li

“…The long-term monitoring of nurses’ mental health and identifying its risk factors are necessary. Accounting for more than one-fifth of global nurses, Chinese nurses have a demanding healthcare workload, especially in tertiary hospitals, yet there is no national cohort concerning their mental health and associated factors. …”
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The efficacy of open transanal drainage tube against anastomotic leakage in left-sided colorectal cancer surgery: a propensity score matching study by Gen Tsujio, Tatsunari Fukuoka, Atsushi Sugimoto, Ken Yonemitsu, Yuki Seki, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Kiyoshi Maeda

“…The multivariate analysis of significant factors identified a BMI of 25 or more, a location of distal edge on middle to lower rectum, and a closed TAT, as independent risk factors for anastomotic leakage (HR: 8.72; p = 0.038, HR: 10.06; p = 0.034 and HR: 17.43; p = 0.033). …”
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Estimating the global health impact of gender-based violence and violence against children: a systematic review and meta-analysis protocol by Joht Singh Chandan, Emmanuela Gakidou, Jaidev Kaur Chandan, Nicholas Metheny, Mariam Khalil, Cory N Spencer, María Jose Baeza, Alexandra Debure, Molly Herbert, Teresa Jewell, Rachel Qian Hui Lim, Sonica Minhas

“…In this protocol, we describe a systematic review and meta-analysis for a comprehensive assessment of the impact of violence exposure on health outcomes and health-related risk factors across the life-course.Methods and analysis Electronic databases (PubMed, Embase, CINAHL, PsycINFO, Global Index Medicus, Cochrane and Web of Science Core Collection) will be searched from 1 January 1970 to 30 September 2021 and searches updated to the current date prior to final preparation of results. …”
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Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior by Elena Martin-Garcia, Laura Domingo-Rodriguez, Beat Lutz, Rafael Maldonado, Inigo Ruiz de Azua

“…Conclusions: CB1 in CaMKII+ neurons is instrumental in feeding behavior and energy storage under physiological conditions. The exposure to risk factors (hypercaloric diet, glucocorticoid dysregulation) leads to obesity, metabolic syndrome, binge-eating and food addiction.…”
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Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics by Luis Agüera-Ortiz, Rocío García-Ramos, Francisco J. Grandas Pérez, Jorge López-Álvarez, José Manuel Montes Rodríguez, F. Javier Olazarán Rodríguez, Javier Olivera Pueyo, Carmelo Pelegrín Valero, Jesús Porta-Etessam

“…Depressive symptoms, enhanced by multiple patient circumstances, were considered Parkinson’s disease risk factors but not clinical indicators of motor symptom and disease progression. …”
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…These results suggest that hyperglycemic and insulinemic conditions promote cell cycle progression and oncogenic signaling in drug-treated bladder epithelial cells and uncontrolled hyperglycemia and hyperinsulinemia are probably greater cancer risk factors than diabetes drugs.…”
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