Multilevel Analysis Reveals the Critical Role of Cell Death-Related Molecules and Drugs in Temporomandibular Disorders by Yuxin Zhang, Xiaoyu Liao, Dahe Zhang, Qingyu Xu, Lingtong Bu, Pei Shen, Jisi Zheng, Chi Yang

Get full text

Pangenome graph analysis reveals extensive effector copy-number variation in spinach downy mildew. by Petros Skiadas, Sofía Riera Vidal, Joris Dommisse, Melanie N Mendel, Joyce Elberse, Guido Van den Ackerveken, Ronnie de Jonge, Michael F Seidl

“…The pangenome graph demonstrates that P. effusa genomes are highly conserved, both in chromosomal structure and gene content, and revealed the continued activity of transposable elements which are directly responsible for 80% of the observed variation between the isolates. …”
Get full text

Preliminary Proteomic and Metabolomic Analyses Reveal Potential Serum Biomarkers for Identifying Alveolar Echinococcosis in Mice by Qing Zhang, Xiongying Zhang, Na Liu, Jia Liu, Wei Wang, Yongshun Wang, Wen Lei, Cunzhe Zhao, Wanli Ma, Shuai Guo, Huixia Cai, Jingxiao Zhang, Yufang Liu, Kemei Shi, Wen Zhang, Xiao Ma

Get full text

A Cretaceous mite with ultra-long setae possibly reveals the early survival strategy of Chyzeriidae by Yu Liu, Qing-Hai Fan, Dong Ren

Get full text

Telemetry reveals rapid duel-driven canary song plasticity in a competitive social environment by Pepe Alcami, Pepe Alcami, Shouwen Ma, Manfred Gahr

“…Overall, our findings reveal context-dependent behavioral flexibility of male-directed canary song signaling, characterized by a moment-to-moment plasticity different from the slow, well-studied seasonal plasticity. …”
Get full text

Transcriptome sequencing reveals the potential mechanisms of dietary lutein regulation on chicken leg muscle development by Tuanhui Ren, Meng Xu, Wujian Lin, Wen Luo, Xiquan Zhang

Get full text

Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat by Yiluo Tan, Kangjun Wang, Mingming Guo, Guangxu Zhang, Xiaofeng Li, Yijun Shi, Maosheng He, Dayong Xu, Feng Chen, Jiwei Fan

“…The metabolite p-aminobenzoic acid (PABA) significantly suppressed the growth of mycelia and the production of conidia in vitro. Further studies revealed that spraying PABA at early anthesis on wheat spikes reduced the development of FHB disease. …”
Get full text

Transcriptome analysis of multiple tissues in the Babylonia areolata reveals the distinct response to Vibrio tubiashii infection by Chen Dai, Dapeng Luo, Qingming Liu, Jing Cui, Haohan Mi, Zuhao Zhang, Zhigang Tu, Minghui Shen

Get full text

Single-cell pseudotime and intercellular communication analysis reveals heterogeneity and immune microenvironment in oral cancer by Hanjun Liu, Lian Xie, Xuemin Xing, Lili Hou, Jinfeng Zhang, Ling Yang

“…Methods Principal component analysis (PCA) followed by dimensionality reduction techniques (UMAP and t-SNE) revealed multiple populations in the single-cell data from oral cancer. …”
Get full text

Comparative genomic analysis of metal-tolerant bacteria reveals significant differences in metal adaptation strategies by Dai Di Chen, Liu Lian Zhang, Jiu Hua Zhang, Wen Ting Ban, Qingxin Li, Jin Chuan Wu

“…Comparative genomic analysis revealed that they have abundant and different genomic features to adapt to various metal ions. …”
Get full text

Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer by Nathan D Maulding, Jun Zou, Wei Zhou, Ciara Metcalfe, Joshua M Stuart, Xin Ye, Marc Hafner

“…When applied to cells treated with either giredestrant, a selective estrogen receptor (ER) antagonist and degrader, or palbociclib, a CDK4/6 inhibitor, pathways dynamically associated with resistance are revealed. For example, ER activity is associated with positive selection around day four under palbociclib treatment and this adaptive response can be suppressed by combining the drugs. …”
Get full text

Haplotype-resolved genome reveals haplotypic variation and the biosynthesis of medicinal ingredients in Areca catechu L. by Chao Wang, Lei Tan, Zhonghui Zhang, Xianggui Li, Linghao Xia, Peng Cao, Haiyang Tong, Xumin Ou, Shixuan Li, Jianing Zhang, Chun Li, Jun Yang, Wen-Biao Jiao, Shouchuang Wang

“…A comparative analysis of the haplotypes revealed significant divergence, including multiple Mb-level large inversions. …”
Get full text

Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn’s disease location by Stefano Levi Mortera, Valeria Marzano, Federica Rapisarda, Chiara Marangelo, Ilaria Pirona, Pamela Vernocchi, Marta Di Michele, Federica Del Chierico, Maria A. Quintero, Irina Fernandez, Hajar Hazime, Rose M. Killian, Norma Solis, Mailenys Ortega, Oriana M. Damas, Siobhan Proksell, David H. Kerman, Amar R. Deshpande, Luis Garces, Franco Scaldaferri, Antonio Gasbarrini, Maria T. Abreu, Lorenza Putignani

Get full text

Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo. by Bharath Ananthasubramaniam, Ramji Venkataramanan

Get full text

Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals by Yanmin Liu, Qinwei Qiu, Yang Chen, Yusheng Deng, Wei Huang, Chen Sun, Xiaoxiao Shang, Xinyan Chen, Chengrui Wang, Lijuan Han, Shiyan Chen, Jiamin Yuan, Fuping Xu, Zhimin Yang, Xiaodong Fang, Li Huang

“…Our integrated multi-omics analysis revealed significant alterations in several regulatory pathways associated with pre-diabetes, particularly emphasizing the impact of gut bacterium Flavonifractor plautii on blood glucose levels through its influence on carbohydrate metabolism. …”
Get full text

Machine learning helps reveal key factors affecting tire wear particulate matter emissions by Zhenyu Jia, Jiawei Yin, Tiange Fang, Zhiwen Jiang, Chongzhi Zhong, Zeping Cao, Lin Wu, Ning Wei, Zhengyu Men, Lei Yang, Qijun Zhang, Hongjun Mao

“…However, obtaining TWPs under real driving conditions and revealing key factors affecting TWPs are challenging. …”
Get full text

Targeting Methionine Metabolism Reveals AMPK-SAMTOR Signaling as a Therapeutic Vulnerability in Prostate Cancer by Serdar Arisan, Ayyuce Sever, Pinar Obakan-Yerlikaya, Elif Damla Arisan, Pinar Uysal-Onganer

Get full text

Microbiome analysis reveals dynamic changes of gut microbiota in Guizhou horse and Dutch Warmblood horses by Yanfang Lan, Yaonan Li, Yang Wang

Get full text

Machine Learning Approach for Biopsy-Based Identification of Eosinophilic Esophagitis Reveals Importance of Global features by Tomer Czyzewski, Nati Daniel, Mark Rochman, Julie Caldwell, Garrett Osswald, Margaret Collins, Marc Rothenberg, Yonatan Savir

Get full text

Long-read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons by Jishu Xu, Michaela Hörner, Elena Buena Atienza, Kalaivani Manibarathi, Maike Nagel, Stefan Hauser, Jakob Admard, Nicolas Casadei, Stephan Ossowski, Rebecca Schuele

Get full text