Reconstruction of Araucaria araucana cone production reveals warming intensifies regionally synchronized masting by Andrew Hacket‐Pain, Fidel A. Roig, Davide Ascoli, Carlos LeQuesne, Martin Hadad

“…Over the last four decades, direct observations of annual cone production in this species revealed remarkable range‐wide synchrony of masting. …”
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Exposure to persistent organic pollutants and sarcopenia: Revealing associations, mediated modifications, and potential mechanisms by Jinlong Tao, Jinchan Zhai, Jiaqi Yang, Qiang Niu, Yunhua Hu, Yizhong Yan

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Natural Compounds in Cancer Therapy: Revealing the Role of Flavonoids in Renal Cell Carcinoma Treatment by Zixuan Chen, Min Liu

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Microscale iron and sulphur isotopic compositions reveal pyritization pathways during early diagenesis by Virgil Pasquier, Johanna Marin-Carbonne, Thomas Giunta, Livio Ruffine, Itay Halevy

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Macrophages and cardiac lesion in zebrafish: what can single-cell RNA sequencing reveal? by Rebeca Bosso dos Santos Luz, André Guilherme Portela Paula, Andressa Pacheco Czaikovski, Bruno Sime Ferreira Nunes, Jordana Dinora De Lima, Lais Cavalieri Paredes, Thais Sibioni Berti Bastos, Rebecca Richardson, Tarcio Teodoro Braga

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Repeat-based holocentromeres of the woodrush Luzula sylvatica reveal insights into the evolutionary transition to holocentricity by Yennifer Mata-Sucre, Marie Krátká, Ludmila Oliveira, Pavel Neumann, Jiří Macas, Veit Schubert, Bruno Huettel, Eduard Kejnovský, Andreas Houben, Andrea Pedrosa-Harand, Gustavo Souza, André Marques

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Multi-modal clustering reveals event-free patient subgroup in colorectal cancer survival by Nikita Janakarajan, Guillaume Larghero, María Rodríguez Martínez

“…An analysis of variance and gene set enrichment coupled with clinical characterisation of the clusters reveal findings that support multi-omics-driven precision medicine in CRC.…”
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Spectroscopic techniques in the investigation of extraordinary medieval Polish coins: Revealing the presence of hidden cores by Trela Krystian, Gójska Aneta Maria, Miśta-Jakubowska Ewelina A., Kelemen Mitja, Šmit Žiga, Kędzierski Adam, Garbacz-Klempka Aldona

“…Unlike Roman denarii, which revealed their cores when broken, the examination of cross denars without damage is challenging. …”
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Comparative genomic analyses reveal different genetic basis of two types of fruit in Maloideae by Yi Wang, Hongju Hu, Juntong Jin, Hui Yuan, Jingguo Zhang, Yuqing Wang, Mingqian Wang, Shaobo Yin, Jiaming Zhao, Shijiao Lin, Yuling Liang, Jiayao Wang, Shipeng Wei, Weiting Liu, Bin Li, Yinglin Ji, Aide Wang

“…Comparative genomic analyses reveal that allele-specific structural variations result in the loss of EIF1 and/or EIF2, removing the suppression on ACS1 transcription and generating ethylene-dependent fruit. …”
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Complete mitochondrial genome of Polygonatum cyrtonema Hua reveals variation diversity and evolutionary trends by Haoxiang Luo, Fengxiao Ren, Guochao Cao, Dekai Wang, Qiaojun Jia

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Genome‐scale metabolic modeling reveals key features of a minimal gene set by Jean‐Christophe Lachance, Dominick Matteau, Joëlle Brodeur, Colton J Lloyd, Nathan Mih, Zachary A King, Thomas F Knight, Adam M Feist, Jonathan M Monk, Bernhard O Palsson, Pierre‐Étienne Jacques, Sébastien Rodrigue

“…Comparing this prediction to the minimal cell JCVI‐syn3.0 and its parent JCVI‐syn1.0 revealed key features of a minimal gene set. iJL208 is a stepping‐stone toward model‐driven whole‐genome engineering.…”
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Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity by Yu Liao, Mingchao Wang, Fuli Qin, Taotao Liu, Jiemei Chen

“…The metabolic pathway, insulin signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, lipid and atherosclerosis pathway, and core targets including CPS1, HRAS, MAPK14, PAH, ALDOB, AKT1, GSK3B, HSP90AA1, BHMT2, EGFR, CASP3, MAT1A, APOM, APOA2, APOC3, and APOA1 are involved in regulating the therapeutic effect of Cpn.ConclusionThis study comprehensively uncovers the potential mechanism of Cpn against obesity based on network pharmacology and quantitative transcriptomics, which provides evidence for revealing the pathogenesis of obesity, suggesting that Cpn is a possible lead compound for anti-obesity treatment.…”
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Changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional MRI. by Huasheng Liu, Jian Liao, Weixiong Jiang, Wei Wang

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Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes by Christopher T Schafer, Raymond F Pauszek III, Martin Gustavsson, Tracy M Handel, David P Millar

“…To investigate the role of conformational dynamics in the distinct pharmacological behaviors of CXCR4 and ACKR3, we employed single-molecule FRET to track discrete conformational states of the receptors in real-time. The data revealed that apo-CXCR4 preferentially populates a high-FRET inactive state, while apo-ACKR3 shows little conformational preference and high transition probabilities among multiple inactive, intermediate and active conformations, consistent with its propensity for activation. …”
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Late Cretaceous Construction of the Mantle Lithosphere Beneath the Central California Coast Revealed by Crystal Knob Xenoliths by D. P. Quinn, J. B. Saleeby, M. N. Ducea, P. Luffi, P. D. Asimow

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Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. by Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth

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Sociodemographically differential patterns of chronic pain progression revealed by analyzing the all of us research program data by Edwin Baldwin, Jin Zhou, Wenting Luo, W. Michael Hooten, Jungwei W. Fan, Haiquan Li

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Transcriptome sequencing revealed the regulation of stem internode length associated with mechanical harvesting in three tea varieties by Xiaozeng Mi, Xiaozeng Mi, Dahe Qiao, Dahe Qiao, Chun Yang, Chun Yang, Juan Chen, Sihui Liang, Sihui Liang, Yan Guo, Yan Guo

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Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models. by Michelle F Craft, Andrea K Barreiro, Shree Hari Gautam, Woodrow L Shew, Cheng Ly

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Single‐Cell Transcriptomics Revealed E‐Cigarettes‐Induced Vascular Remodeling by Enhancing Tcf21 Expression by Ruiyang Ding, Xiaoke Ren, Qinglin Sun, Shiqian liu, Linyuan Huang, Zhiwei Sun, Junchao Duan

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