Tissue metabolomics reveals metabolic dysregulation associated with intimal hyperplasia in arteriovenous fistula stenosis by Ming Zhao, Qixin Wu, Yifei Zhao, Rui Nian, Wanjun Li, Hongzhao Lu

“…Histological analysis revealed significant intimal hyperplasia in stenotic tissues (687.90 ± 149.00 μm vs. 286.70 ± 95.18 μm, P < 0.0001 by HE staining) and excessive collagen deposition (Masson staining).ResultsMetabolomic profiling identified 802 metabolites, with 356 differentially expressed (VIP > 1, P < 0.05), predominantly lipids/lipid-like molecules. …”
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Comprehensive Analysis Reveals Midnolin as a Potential Prognostic, Therapeutic, and Immunological Cancer Biomarker by Xin-Guo Zhang, Wen-Ting Li, Xin Jin, Chuang Fu, Wen Jiang, Jie Bai, Zhi-Zhou Shi

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Transcriptome-based analysis reveals relationship between duck eggshell color and eggshell strength by Longxin Wang, Hehe Liu, Simeng Yu, Meixi Lu, Yunsheng Zhang, Shuaiqin Wang, Shuisheng Hou

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ALMA Reveals Thermal and Nonthermal Desorption of Methanol Ice in the HD 100546 Protoplanetary Disk by Lucy Evans, Alice S. Booth, Catherine Walsh, John D. Ilee, Luke Keyte, Charles J. Law, Margot Leemker, Shota Notsu, Karin Öberg, Milou Temmink, Nienke van der Marel

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Metagenomics reveals fibre fermentation and AMR pathways in red grouse (Lagopus scotica) microbiota by Anum Ali Ahmad, Kathy Fletcher, Nicholas Hesford, Laura Glendinning

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Combined metabolomic and transcriptomic analysis reveals the key genes for triterpenoid biosynthesis in Cyclocarya paliurus by Duo Chen, Xupeng Chen, Xuehai Zheng, Jinmao Zhu, Ting Xue

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Comparative Analyses Reveal Mitogenome Characteristics of Halictidae and Novel Rearrangement (Hymenoptera: Apoidea: Anthophila) by Dan Zhang, Zeqing Niu

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Integrated systems analysis reveals a molecular network underlying autism spectrum disorders by Jingjing Li, Minyi Shi, Zhihai Ma, Shuchun Zhao, Ghia Euskirchen, Jennifer Ziskin, Alexander Urban, Joachim Hallmayer, Michael Snyder

“…Analysis of functional genomic data further revealed a significant involvement of this module in the development of oligodendrocyte cells in mouse brain. …”
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Next-Generation Sequencing Reveals Frequent Opportunities for Exposure to Hepatitis C Virus in Ghana. by Joseph C Forbi, Jennifer E Layden, Richard O Phillips, Nallely Mora, Guo-Liang Xia, David S Campo, Michael A Purdy, Zoya E Dimitrova, Dorcas O Owusu, Lili T Punkova, Pavel Skums, Shirley Owusu-Ofori, Fred Stephen Sarfo, Gilberto Vaughan, Hajung Roh, Ohene K Opare-Sem, Richard S Cooper, Yury E Khudyakov

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Biosynthesis-based metabolomics analysis reveals chemical diversity between two Salvia species by Feiyan Wang, Chenyi Li, Haizheng Yu, Dongfeng Yang, Ji Ye, Lei Zhang, Lei Zhang

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Fluorescence lifetime imaging microscopy approach reveals quantitative signatures for hepatocellular carcinoma diagnosis by Lingyun Li, Lingyun Li, Aoshan Wang, Xiongqing Liu, Ganlu Wang, Shanjie Xu, Changjiang Li, Wenzhong Wu, Xiaoying Zhang, Zhendan He, Huiling Qiu, Xiao Peng, Wei Yan, Junle Qu

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Statistical Distributions of Genome Assemblies Reveal Random Effects in Ancient Viral DNA Reconstructions by Fernando Antoneli, Cristina M. Peter, Marcelo R. S. Briones

“…Our results show that the tails of the distributions of aDNA and their controls reveal the weight of random effects and can differentiate spurious assemblies, or false positives, from bona fide assemblies.…”
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Reduced representation sequencing reveals genetic diversity and adaptive genetic divergence in Calamus rhabdocladus by Rui Gu, Ruijing Xu, Songpo Wei, Pär K. Ingvarsson, Shaohui Fan, Guanglu Liu

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Comparative transcriptomes and WGCNA reveal hub genes for spike germination in different quinoa lines by Liubin Huang, Lingyuan Zhang, Ping Zhang, Junna Liu, Li Li, Hanxue Li, Xuqin Wang, Yutao Bai, Guofei Jiang, Peng Qin

“…Further functional annotation revealed four key transcription factors involved in the regulation of dormancy and germination processes: gene LOC110698065, gene LOC110696037, gene LOC110736224, and gene LOC110705759, belonging to the bHLH, NF-YA, MYB, and FAR1 gene families, respectively. …”
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Integrative eQTL and Mendelian randomization analysis reveals key genetic markers in mesothelioma by Jinsong Li, Xingmeng Wang, Yaru Lin, Zhengliang Li, Wei Xiong

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Genome-wide selection reveals candidate genes associated with multiple teats in Hu sheep by Wen Zhou, Cheng-long Zhang, Zhipeng Han, Xiaopeng Li, Xinyu Bai, Jieru Wang, Ruizhi Yang, Shudong Liu

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NHANES 2005–2018 data reveal high albumin-bilirubin scores are associated with depression by Qing-Zhong Li, Jia-Xin Tan, Guo-Tian Ruan, Quan-Zhi Qin, Teng Deng, Yi-Zhen Gong

“…The analysis of variance revealed a significant dose–response relationship between ALBI and depression symptom severity (P < 0.05). …”
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Paired proteomic analysis reveals protein alterations in sun-exposed skin of professional drivers by Amanda C. Camillo-Andrade, Lucas A. Sales, Juliana S. G. Fischer, Rosario Duran, Marlon D. M. Santos, Paulo C. Carvalho

“…Leveraging this approach, our study reveals sun-induced overexpression of proteins linked to photoaging through paired proteomic analysis, providing novel insights into the skin’s adaptive responses to chronic solar exposure. …”
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Multi-Omics Integration Reveals the Impact of Gastrointestinal Microbiota on Feed Efficiency in Tan Sheep by Guohan Sun, Xiaohong Han, Tonggao Liu, Xinrui Zhang, An Shi, Chong Yang, Jinzhong Tao

“…Correlations can be seen with microorganisms such as Parasutatella and Lactobacillus in the cecum; Turicibacter, norank_f__Bacteroideales_UCG-001, and Blautia in the rectum; and metabolites such as L-tryptophan, Etiocholanolone glucuronide, and N-acetyl-O-demethylpuromycin. This reveals the role of microorganisms in the digestion and absorption of Tan sheep feed, thus providing a preliminary basis for further research on the microbial regulation of ruminant animal feed utilization and a theoretical basis for improving Tan sheep feed utilization efficiency.…”
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Cryoimmobilized anther analysis reveals new ultrastructural insights into Rhynchospora (Cyperaceae) asymmetrical microsporogenesis by Danilo M. Rocha, Ulla Neumann, Fernanda M. Nogueira, Georgios Tsipas, André L. L. Vanzela, André Marques

“…Despite significant advances, the ultrastructural details of these processes remain poorly understood.MethodsThis study provides a detailed analysis of microsporogenesis in Rhynchospora pubera using high-pressure freezing, freeze substitution, and transmission electron microscopy, significantly enhancing ultrastructural resolution.Results and discussionOur findings reveal that intracellular organization differs from model species Arabidopsis thaliana and drives nuclear selection, with endoplasmic reticulum vesicles organizing meiotic spindles. …”
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