Integrated Bioinformatics and Experimental Validation Reveal Macrophage Polarization-Related Biomarkers for Osteoarthritis Diagnosis by He Q, Liu L, Hu X, Lin L, Song Z, Xia Y, Lin Q, Wei J, Li S

“…In vitro experiments revealed that the hub genes in the synovial tissue of OA patients were significantly down-regulated (P < 0.01), confirming their potential as diagnostic biomarkers.Conclusion: We constructed an OA diagnostic model related to macrophage polarization through comprehensive bioinformatics analysis, and the results indicated that these genes have high diagnostic value. …”
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PSMA PET/CT scan reveals incidental meningioma in a prostate cancer patient by Venetia A. Florou, Aditya Halthore, Calixto-Hope G. Lucas, Carlos A. Rivera Lopez, Kenneth J. Pienta

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Ehrlichia chaffeensis proteomic profiling reveals distinct expression patterns of infectious and replicating forms by Chandramouli Kondethimmanahalli, Roman R. Ganta, Roman R. Ganta

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MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis by Misu Xiao, Cheng Guo, Quanjun Yang

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Multi-omics analysis reveals genetic architecture and local adaptation of coumarins metabolites in Populus by Wenke Zhang, Zhuoying Jin, Rui Huang, Weixiong Huang, Lianzheng Li, Yuling He, Jiaxuan Zhou, Chongde Tian, Liang Xiao, Peng Li, Mingyang Quan, Deqiang Zhang, Qingzhang Du

“…Furthermore, we constructed a genetic network of seven candidate genes that coordinately regulate coumarins biosynthesis, revealing the multiple regulatory patterns affecting coumarins accumulation in Populus tomentosa. …”
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Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling by Yannick Blum, Jan Mikelson, Maciej Dobrzyński, Hyunryul Ryu, Marc‐Antoine Jacques, Noo Li Jeon, Mustafa Khammash, Olivier Pertz

“…Temporally controlled GF perturbations of MAPK signaling dynamics applied using microfluidics reveal that this wider mix of ERK states emerges through the combination of an intracellular feedback, and competition of FGF2 binding to FGF receptors (FGFRs) and heparan sulfate proteoglycan (HSPG) co‐receptors. …”
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Revealing electron transport connectivity as an important factor influencing stability of organic solar cells by Haixia Hu, Rui Zhang, Dongcheng Jiang, Xinyu Mu, Jicheng Yi, Han Yu, Lik-Kuen Ma, Bin Li, Lingxin Cao, Mengzhen Sha, Jiangkai Sun, Ruohua Gui, Wei Liu, Shijie Liang, Longlong Li, Shufen Huang, Jianyu Yuan, Chengwang Niu, Cunquan Qu, Jun Yuan, Rongkun Zhou, Chen Zhang, Lin Lu, Xiaoyan Du, Kun Gao, Weiwei Li, Shu Kong So, Yingping Zou, Yanming Sun, Xiaotao Hao, Feng Gao, He Yan, Hang Yin

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Integration of transcriptome and metabolome reveals tolerance mechanism to high salinity stress in Crassostrea hongkongensis by Yixin Zhang, Qiwen Liang, Feifei Yu, Jiexiong Zhu, Jianfang Gui, Jinji Lin, Yishan Lu, Haiyuan Tao

“…In this study, the transcriptomic and metabolomic were conjointly analyzed to reveal the tolerance mechanism of C. hongkongensis in response to high salinity stress. …”
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Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis by Hanibal Bohnenberger, Lars Kaderali, Philipp Ströbel, Diego Yepes, Uwe Plessmann, Neekesh V Dharia, Sha Yao, Carina Heydt, Sabine Merkelbach‐Bruse, Alexander Emmert, Jonatan Hoffmann, Julius Bodemeyer, Kirsten Reuter‐Jessen, Anna‐Maria Lois, Leif Hendrik Dröge, Philipp Baumeister, Christoph Walz, Lorenz Biggemann, Roland Walter, Björn Häupl, Federico Comoglio, Kuan‐Ting Pan, Sebastian Scheich, Christof Lenz, Stefan Küffer, Felix Bremmer, Julia Kitz, Maren Sitte, Tim Beißbarth, Marc Hinterthaner, Martin Sebastian, Joachim Lotz, Hans‐Ulrich Schildhaus, Hendrik Wolff, Bernhard C Danner, Christian Brandts, Reinhard Büttner, Martin Canis, Kimberly Stegmaier, Hubert Serve, Henning Urlaub, Thomas Oellerich

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Digital volumetric modeling reveals unique body plan experimentation in the Devonian tetrapod Ichthyostega by Catherine R.C. Strong, Peter J. Bishop, John R. Hutchinson, Stephanie E. Pierce

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A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress. by Liu Yang, Zhen Xue, Yin He, Shengyi Sun, Hui Chen, Ling Qi

“…This method allowed for a quantitative assessment of the level of stress in the ER. Our data revealed quantitatively the extent of tissue-specific basal ER stress as well as ER stress caused by the accumulation of misfolded proteins and the fasting-refeeding cycle. …”
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To reveal biomarkers related to macrophage and lactic acid metabolism in renal fibrosis and explore their mechanisms by Chen Yong, Chen Yong, Yongfei Yu, Yongfei Yu, Yuan Wei, Yuan Wei, Guoshun Huang, Guoshun Huang, Lianghui Shu, Lianghui Shu, Kun Gao, Kun Gao, Kun Gao, Enchao Zhou, Enchao Zhou, Enchao Zhou, Enchao Zhou

“…Subsequent enrichment analysis revealed that three biomarkers were collectively enriched to 50 signaling pathways, including “Toll-like receptor signaling pathway”, “oxidative phosphorylation”, and “P53 signaling pathway”. …”
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Cognitive computational model reveals repetition bias in a sequential decision-making task by Eric Legler, Darío Cuevas Rivera, Sarah Schwöbel, Ben J. Wagner, Stefan Kiebel

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Glacier inventories reveal an acceleration of Heard Island glacier loss over recent decades by L. G. Tielidze, L. G. Tielidze, A. N. Mackintosh, A. N. Mackintosh, W. Yang

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AI and Eye Tracking Reveal Design Elements’ Impact on E-Magazine Reader Engagement by Hedda Martina Šola, Fayyaz Hussain Qureshi, Sarwar Khawaja

“…Python-based analysis revealed that the HND article consistently outperformed OxFoodbank in maintaining reader engagement and attention. …”
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Multiomics analysis reveals microbial diversity and activity through spontaneous fermentation of Theobroma cacao by Ynara da Costa Fonseca, Celina Eugenio Bahule, Hector Herrera, Luiza Helena da Silva Martins, Alessandra Santos Lopes, Juliana Silva Cassoli, Felipe Costa Trindade, Isa Rebecca Chagas da Costa, Paulo Henrique de Oliveira Costa, Guilherme Oliveira, Rafael Borges da Silva Valadares

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Coordinating environmental genomics and geochemistry reveals metabolic transitions in a hot spring ecosystem. by Wesley D Swingley, D'Arcy R Meyer-Dombard, Everett L Shock, Eric B Alsop, Heinz D Falenski, Jeff R Havig, Jason Raymond

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Tree-ring width reveals evaporation signals in semi-arid regions of the United States by Lingze Xu, Hongkai Gao, Wenling An, Zheng Duan

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Rapid paralysis and hidden malignancy: acute motor axonal neuropathy revealing pleomorphic liposarcoma by Sathish Kumar Krishnan, Vijaya Sivalingam Ramalingam, Melissa Johnson

“…Despite standard treatment with intravenous immunoglobulin, the patient experienced no neurological recovery. Further imaging revealed a large pelvic mass, that was not present on a scan performed two months earlier. …”
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What a Human-Centred Approach Reveals About Disinformation Policies: The Baltic Case by Auksė Balčytienė, Agnese Dāvidsone, Andra Siibak

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