Machine-learning of medical cannabis chemical profiles reveals analgesia beyond placebo expectations by Adi Hatav, Yelena Vysotski, Anna Shapira, Shiri Procaccia, David Meiri, Dvir Aran

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Machine Learning Reveals Microbial Taxa Associated with a Swim across the Pacific Ocean by Garry Lewis, Sebastian Reczek, Osayenmwen Omozusi, Taylor Hogue, Marc D. Cook, Jarrad Hampton-Marcell

“…More importantly, microbial dynamics reveal the microbial taxa significantly associated with increased exercise volume, highlighting specific microbes responsive to excessive swimming.…”
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Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation by Shuai Yuan, Jie Chen, Xixin Ruan, Yuying Li, Sarah A. Abramowitz, Lijuan Wang, Fangyuan Jiang, Ying Xiong, Michael G. Levin, Benjamin F. Voight, Dipender Gill, Stephen Burgess, Agneta Åkesson, Karl Michaëlsson, Xue Li, Scott M. Damrauer, Susanna C. Larsson

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In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons by Wanjie Wu, Yingzhu He, Yujun Chen, Yiming Fu, Sicong He, Kai Liu, Jianan Y. Qu

“…Through in vivo imaging, our findings reveal a neuroprotective role of microglia during the acute phase of single spinal cord axon injury, achieved through neuron-glia interaction.…”
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Genomic resequencing reveals genetic diversity, population structure, and core collection of durian germplasm by Yiwang Zhong, Liying Feng, Huidong Deng, Xiaohao Ji, Jing Zhang, Yangyang Sun, Peifan Lin, Yang Qiao, Shenghua Xie, Haibo Wang, Lijun Guo, Xuejie Feng

“…We performed whole-genome resequencing of 114 diverse durian accessions collected in China, identifying over 39 million high-quality SNPs across the genome, revealing genome-wide patterns of diversity. Population structure analysis revealed three major genetic clusters, supported by PCA, phylogenetic analysis, and STRUCTURE modeling. …”
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Multi-kingdom microbiota analysis reveals bacteria-viral interplay in IBS with depression and anxiety by Qin Liu, Wenyu Fang, Ping Zheng, Shicai Xie, Xuanting Jiang, Wen Luo, Lijuan Han, Ling Zhao, Lin Lu, Lixiang Zhai, Danny J. Yu, Wei Yang, Chengyuan Lin, Xiaodong Fang, Zhaoxiang Bian

“…Here, we analyze the gut multi-kingdom microbiota of 360 IBS patients from a prospective cohort study in Hong Kong, with participants phenotyped through psychological assessment. Our findings reveal significantly lower intra-community correlations in IBS patients compared to healthy controls and highlight unique taxa patterns associated with IBS and mental disorders. …”
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Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria by Stephanie I Studniberg, Lisa J Ioannidis, Retno A S Utami, Leily Trianty, Yang Liao, Waruni Abeysekera, Connie S N Li‐Wai‐Suen, Halina M Pietrzak, Julie Healer, Agatha M Puspitasari, Dwi Apriyanti, Farah Coutrier, Jeanne R Poespoprodjo, Enny Kenangalem, Benediktus Andries, Pak Prayoga, Novita Sariyanti, Gordon K Smyth, Alan F Cowman, Ric N Price, Rintis Noviyanti, Wei Shi, Alexandra L Garnham, Diana S Hansen

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Revealing the nuances of 'Grey Digital Divide' in Hong Kong: A latent profile analysis. by Bobo Hi-Po Lau, Eric Ngai-Yin Shum, Alex Pak-Ki Kwok, Ben Chi-Pun Liu, Alex Chi-Keung Chan, Rick Yiu-Cho Kwan, Steve Fu-Fai Fong, Gigi Lam, Chung-Kin Tsang, Daniel Dick-Man Leung, Johnson Chun-Sing Cheung, Jason Tak-Sang Chow, Paulina Pui-Yun Wong, Stuart Gietel-Basten

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Combining satellite and field data reveals Congo's forest types structure, functioning and composition by Juliette Picard, Maïalicah M. Nungi‐Pambu Dembi, Nicolas Barbier, Guillaume Cornu, Pierre Couteron, Eric Forni, Gwili Gibbon, Felix Lim, Pierre Ploton, Robin Pouteau, Paul Tresson, Tom vanLoon, Gaëlle Viennois, Maxime Réjou‐Méchain

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Geoarchaeology reveals development of terrace farming in the Northern Apennines during the Medieval Climate Anomaly by Filippo Brandolini, Tim C. Kinnaird, Aayush Srivastava, Stefano Costanzo, Chiara Compostella, Sam Turner

“…By uncovering the construction dates of terrace farming systems in the northern Apennines region, the research reveals a distinct temporal framework, indicating that the establishment of agricultural terraces predominantly occurred during the 11th to 13th centuries CE. …”
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Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. by Kristina Kirschner, Shamith A Samarajiwa, Jonathan M Cairns, Suraj Menon, Pedro A Pérez-Mancera, Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott K Lyons, Andy G Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita

“…Using the p53 targets seen in the chronic conditions together with external high-throughput datasets, we have built p53 networks that revealed extensive self-regulatory 'p53 hubs' where p53 and many p53 targets can physically interact with each other. …”
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Comparative analysis of mitochondrial genomes in lycoperdaceae fungi reveals intron dynamics and phylogenetic relationships by Xianyi Wang, Guoyu Wang, Jiawei Tao, Zhongyao Guo, Guangyin Xu, Jiayu Li, Jichuan Kang, Qin Zuo, Hongmei Liu, Qirui Li

“…Comparative analysis revealed the contribution of gene composition and introns to the mitochondrial genome size. …”
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High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation by Jelle Slager, Hanna L. Simpson, Ranko Gacesa, Lianmin Chen, Ineke L. Tan, Jody Gelderloos, Astrid Maatman, Cisca Wijmenga, Alexandra Zhernakova, Jingyuan Fu, Rinse K. Weersma, Gieneke Gonera, Iris H. Jonkers, Sebo Withoff

“…In addition, the immotile European subspecies of Eubacterium rectale, which has a distinct carbohydrate metabolism potential, was nearly absent in tCeD patients.Conclusion Our study sheds light on the complex interplay between the gut microbiome and CeD, revealing increased interindividual variation and strain-level variation in tCeD patients. …”
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Single‐cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma by Lise Finotto, Basiel Cole, Wolfgang Giese, Elisabeth Baumann, Annelies Claeys, Maxime Vanmechelen, Brecht Decraene, Marleen Derweduwe, Nikolina Dubroja Lakic, Gautam Shankar, Madhu Nagathihalli Kantharaju, Jan Philipp Albrecht, Ilse Geudens, Fabio Stanchi, Keith L Ligon, Bram Boeckx, Diether Lambrechts, Kyle Harrington, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet, Holger Gerhardt

“…Here, we used patient‐derived GBM stem cell cultures and combined single‐cell RNA sequencing of GAM‐GBM co‐cultures and real‐time in vivo monitoring of GAM‐GBM interactions in orthotopic zebrafish xenograft models to provide insight into the cellular, molecular, and spatial heterogeneity. Our analyses revealed substantial heterogeneity across GBM patients in GBM‐induced GAM polarization and the ability to attract and activate GAMs—features that correlated with patient survival. …”
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Mitochondrial thermal proteome profiling reveals aberrant activation of pyruvate dehydrogenase upon cuproptosis by Zongyu Huang, Yanjun Liu, Ya Zeng, Jun Wang, Siyuan Sun, Chris Soon Heng Tan, Peng R. Chen

“…We developed Mito-TPCA, a mitochondrial thermal proximity coaggregation strategy combining enzyme-catalyzed proteome labeling with thermal profiling, to map mitochondrial protein-protein interaction dynamics during cuproptosis. This approach revealed that copper disrupts the association of pyruvate dehydrogenase kinases (PDKs) with the pyruvate dehydrogenase (PDH) complex by targeting lipoyl domains, triggering PDH dephosphorylation and aberrant activation. …”
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Genetic Adaptations of Soybean to Cold Stress Reveal Key Insights Through Transcriptomic Analysis by Xiulin Liu, Chunlei Zhang, Sobhi F. Lamlom, Kezhen Zhao, Ahmed M. Abdelghany, Xueyang Wang, Fengyi Zhang, Rongqiang Yuan, Dezhi Han, Bire Zha, Wencheng Lu, Honglei Ren, Bixian Zhang

“…A comparative physiological marker study revealed distinct reactions to cold stress in the two cultivars. …”
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Mass spectrometric profiling reveals association of -glycan patterns with epithelial ovarian cancer progression by Huanhuan Chen, Zaian Deng, Chuncui Huang, Hongmei Wu, Xia Zhao, Yan Li

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Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks by Davide Momi, Zheng Wang, Sara Parmigiani, Ezequiel Mikulan, Sorenza P. Bastiaens, Mohammad P. Oveisi, Kevin Kadak, Gianluca Gaglioti, Allison C. Waters, Sean Hill, Andrea Pigorini, Corey J. Keller, John D. Griffiths

“…We investigated this question using rare simultaneous multimodal electrophysiology (stereotactic and scalp electroencephalography - EEG) recordings in 36 patients with drug-resistant focal epilepsy during presurgical intracerebral electrical stimulation (iES) (323 stimulation sessions). Our analyses revealed an anatomical gradient of excitability across the cortex, with stronger iES-evoked EEG responses in high-order compared to low-order regions. …”
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Transcriptome profiling of Anoectochilus roxburghii L. reveals spermidine-mediated response to drought stress by Muhammad Waheed Riaz, Qingjun Zou, Ailian Zhang, Aicun Zhou, Muhammad Yasir, Chunqing Chen, Ying Zheng, Qingsong Shao

“…The comparative transcriptomic analysis revealed significant changes in differentially expressed genes (DEGs) across all tissues. …”
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Multimodal Metabolomic Analysis Reveals Novel Metabolic Disturbances in Adults With Early Treated Phenylketonuria by Yann Dos Santos, Patrick Emond, Ida Vanessa Doederlein Schwartz, Antoine Lefèvre, Camille Dupuy, Gabrielle Chicheri, Hélène Blasco, François Maillot

“…Untargeted analysis confirms previous findings regarding the TCA cycle, alanine aspartate glutamate metabolism, arginine and proline metabolism, and revealed some new metabolic perturbations such as arginine biosynthesis or glyoxylate and dicarboxylate metabolism. …”
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