Single-cell RNA sequencing reveals the effects of hederasaponin C in the treatment of diabetic nephropathy by Jing Liu, Qian Zhang, Wentong Zhao, Jinan Guo, Yin Kwan Wong, Chunting Zhang, Weijin Qiu, Piao Luo, Junhui Chen, Junmao Li, Xiaoran Li, Hongwei Gao, Shilin Yang, Yulin Feng, Jigang Wang

“…Here, we investigated the response of murine diabetic models to PB5 treatment using single-cell RNA-sequencing (scRNA-seq) and proteomics. Our findings revealed the dynamic transcriptional changes of renal cells in response to diabetic nephropathy. …”
Get full text

Revealing the Structure and Biodiversity Patterns of Fish Communities in River Networks Based on Environmental DNA by Ziyu Liu, Yongsheng Wu, Wenhui You, Shuxin Li, Ge Shi, Chen Zhang

“…Revealing taxonomic, functional, and phylogenetic dimensions of biodiversity is critical for the effective conservation and management of aquatic organisms in freshwater ecosystems subjected to multiple threats. …”
Get full text

Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome by Mingshuang Li, Conglin Ren, Chenxia Wu, Xinyao Li, Xinyi Li, Wei Mao

“…Early detection and intervention would provide clinical benefits. This study aimed to reveal hub genes, transcription factors (TFs), and microRNAs (miRNAs) that affect plaque stability and provide the possibility for the early diagnosis and treatment of ACS. …”
Get full text

Acoustic exposure reveals variation in curtailment effectiveness at reducing bat fatality at wind turbines by Trevor Peterson, Adam Rusk, Caroline Byrne, Seta Aghababian, Sydney Edwards

Get full text

Satellites reveal different stories of marine heatwaves in the sea-ice-covered pan-Arctic by Xuewei Zhang, Ning Zhao, Zhijun Dai, Zhen Han

“…We found inconsistent behaviors of marine heatwaves in both mean fields and temporal variations on interannual and seasonal timescales using two datasets, which became even larger in recent years when they showed opposite tendencies over regions with higher ice concentrations (>50%). Our findings revealed our knowledge of marine heatwaves in the Arctic is facing challenges due to the large influences of sea ice and datasets that were ignored in previous studies, highlighting an urgent need for in situ observations and consistent and reliable long-time datasets for the warming Arctic.…”
Get full text

Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. by Gareth McVicker, Tomasz K Prajsnar, Alexander Williams, Nelly L Wagner, Michael Boots, Stephen A Renshaw, Simon J Foster

“…In this work, the population dynamics of S. aureus pathogenesis were studied in vivo using antibiotic-resistant strains constructed in an isogenic background, coupled with systemic models of infection in both the mouse and zebrafish embryo. Murine experiments revealed unexpected and complex bacterial population kinetics arising from clonal expansion during infection in particular organs. …”
Get full text

Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets by Ganfei Xu, Juan Yu, Jiacheng Lyu, Mengna Zhan, Jie Xu, Minjing Huang, Rui Zhao, Yan Li, Jiajun Zhu, Jinwen Feng, Subei Tan, Peng Ran, Zhenghua Su, Xinhua Liu, Jianyuan Zhao, Hongwei Zhang, Chen Xu, Jun Chang, Yingyong Hou, Chen Ding

“…Proteogenomic analysis reveals the characteristics of linear multi‐step progression of BRDC, such as tumor protein P53 (TP53) mutation‐associated estrogen receptor 1 (ESR1) overexpression is involved in the transition from ductal hyperplasia (DH) to ductal carcinoma in situ (DCIS). 6q21 amplification‐associated nuclear receptor subfamily 3 group C member 1 (NR3C1) overexpression helps DCIS_Pure (pure DCIS, no histologic evidence of invasion) cells avoid immune destruction. …”
Get full text

Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis by Xiaoshu Dong, Xinqian Yu, Minghao Lu, Yaxin Xu, Liyan Zhou, Tao Peng

“…Overall, our chemical proteomics profiling and functional studies not only reveal BID as the principal target of PEITC in mediating upstream events for the induction of apoptosis, but also uncover a novel molecular mechanism involving N-terminal cysteines within the first helix of BID in regulating its pro-apoptotic potential.…”
Get full text

Integrated Proteomics and Metabolomics Reveal Spermine Enhances Sperm Freezability via Antioxidant Pathways by Lewei Guo, Zhuoxuan Gu, Bing Wang, Yunuo Wang, Jiaorong Chen, Yitong Li, Qiuju Zheng, Jing Zhao, He Ding, Hongyu Liu, Yi Fang, Jun Wang, Wenfa Lyu

“…Sperm proteome analysis revealed upregulated antioxidant proteins (PRDX2, GSTM4), heat shock proteins (HSP70, HSP90), and key enzymes in arginine and proline metabolism (PRODH, LAP3). …”
Get full text

Correction: Head Lice of Pygmies Reveal the Presence of Relapsing Fever Borreliae in the Republic of Congo. by PLOS Neglected Tropical Diseases Editors

Get full text

An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. by Katrin Kremer, Dirk Kamin, Eva Rittweger, Jonathan Wilkes, Halley Flammer, Sabine Mahler, Joanne Heng, Christopher J Tonkin, Gordon Langsley, Stefan W Hell, Vernon B Carruthers, David J P Ferguson, Markus Meissner

Get full text

Genome-wide binding of MBD2 reveals strong preference for highly methylated loci. by Roberta Menafra, Arie B Brinkman, Filomena Matarese, Gianluigi Franci, Stefanie J J Bartels, Luan Nguyen, Takashi Shimbo, Paul A Wade, Nina C Hubner, Hendrik G Stunnenberg

Get full text

Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence by Lu Ding, Lu Ding, Meiling Zhang, Baochao Fan, Fuyuan Deng, Zhenyuan Li, Yixuan Han, Yifan Wu, Jingchun Zeng, Jingchun Zeng, Liming Lu

“…Metabolite analysis revealed associations between decreased proline, isoleucine, valine, and alanine levels with IS. …”
Get full text

Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma by Jian Gao, Qiming Wang, Fangqiu Fu, Yue Zhao, Teng Yang, Xiangze Li, Yihua Sun, Hong Hu, Longfei Ma, Longsheng Miao, Xiaoyang Luo, Ting Ye, Yiliang Zhang, Yang Zhang, Ziling Huang, Hang Li, Longlong Shao, Midie Xu, Kuaile Zhao, Shiyue Zhang, Mou Zhang, Jun Wang, Chong Dai, Xiaoxiao Shang, Tingyi An, Yawei Zhang, Jiaqing Xiang, Zhiwei Cao, Bin Li, Haiquan Chen

Get full text

Revealing the spatial heterogeneity of the gut microbiota of red-feather ducks and their interaction with environmental microorganisms by Surong Zhang, Yun Ye, Boqi Wan, Rui Shao, Yuan Fang, Yuanxiu Wang, Jinyuan Wu, Hui Yang

“…Microbial source tracking further revealed that the microbial composition in water was primarily shaped duck gut microbiota, with a contribution rate of up to 72.77 %. …”
Get full text

Single-Cell Atlas of Spleen Remodeling Reveals Macrophage Subset-Driven ASFV Pathogenesis by Liyuan Wang, Shouzhang Sun, Lei Liu, Yun Chen, Haixue Zheng, Zhonglin Tang

“…Pseudotime analysis revealed dynamic macrophage state transitions during infection. …”
Get full text

Morpho-phylogenetic evidence reveals novel Bambusicolous fungi from Guizhou Province, China by Yao Feng, Ya-Ya Chen, Chuan-Gen Lin, Zuo-Yi Liu, Xiao-Fang Chen, Guo-Shun Pei, Jian-Kui Liu

Get full text

Toward inclusion and social justice in institutional translation and interpreting: Revealing hidden practices of exclusion by Holly Mikkelson

Get full text

Physiological and transcriptomic analyses reveal the regulatory mechanisms for the adaptation of Quercus robur to shade conditions by Xiong Huang, Qiuhong Hu, Mengke Dou, Cai Liu, Jiangtao Fan, Jia Liu, Peng Zhu

“…Furthermore, this study elucidated the transcriptional responses of Q. robur to shading, thereby revealing the molecular mechanisms underlying shade adaptation. …”
Get full text

Metagenomic and Metabolomic Profiling Reveals the Impact of High‐Fat Diet on Malignant Pleural Effusion by Qing‐Yu Chen, Ming‐Ming Shao, Shu‐Feng Dong, Huan‐Zhong Shi, Feng‐Shuang Yi

“…Metagenome data of the intestinal microbiome and metabolome profiles of plasma metabolites revealed key taxa—Akkermansiaceae, Parabacteroides, and Muribaculaceae—as well as significant metabolic pathways involved in sphingolipid metabolism, glycerophospholipid metabolism, and steroid hormone biosynthesis. …”
Get full text